Pharmacology
???????? Topic : Pharmacokinetics : ME????????
1️⃣ (A)—phase I is also known as functionalization reaction
(B)—phase ii is also known as Non-synthetic phase
a)Both statements r true
b)Both statements r false
c)A is true bt B is false
D)B is true bt A is false
2️⃣ All of the following are advantage of prodrug(activated from inactive drug)
EXCEPT:
A) More stable
B)Poor bioavailability
C)less side effects
D)desirable p’kinetic properties
3️⃣ Which enzyme is responsible for metabolism of about 20℅ drugs__
A)CYP2D6
B)CYP2C8
C)CYP3A4
D)CYP2C19
4️⃣ Which reaction shows genetic morphism__
A)Cyclization
B) Hydrolysis
C) Methylation
D) Acetylation
5️⃣ Microsomal & Non-microsomal enzyme are present accordingly __
A)Cytoplasm & SER
B) Mitochondria & RER
C)SER & Cytoplasm,Mitochondria
D)Nome of the above
6️⃣ In 1st order kinetics__
A) Elimination rate is inversely proportional to drug conc.
B) Elimination rate is directly proportional to drug conc.
C) A & B both
D)None of the above
7️⃣ Formula to calculate loading dose is__
A)Target Cp × V / F
B) Target Cp × CL / F
C)0.693 × V / CL
D) Vmax × C / Kmax + C
8️⃣ In zero order kinetics__
A) Elimination rate is directly proportional to drug concentration
B) Elimination rate is inversely proportional to drug conc
C) Elimination rate remains constant
D) none of the above
9️⃣ In the graph of plasma half life , the plot has 2 slopes which are__
A) Alpha ( due to Elimination)
Beta (due to distribution)
B) Beta & Gamma
C)Alpha ( due to distribution)
Beta(due to Elimination)
D) None of the above
???? Formula to find out Clearance is__
A) CL = C/ Elimination rate
B)CL = C × Elimination rate
C) CL = C – Elimination rate
D) CL = Elimination rate / C
Answers
1. C ( A is true but B is false )
2. B ( Poor bioavailability )
3. A ( CYP2D6 )
4. D ( Acetylation )
5. C ( SER & Cytoplasm , Mitochondria )
6. B ( Elimination rate is directly proportional to drug concentration )
7. A ( Target Cp × CL / F )
8. C ( Elimination rate remains constant )
9. C ( Alpha – due to distribution. , Beta – Due to elimination )
10. D ( CL = Elimination rate / C )
