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Antibody Notes 6th sem

Antibody Notes 6th sem

~Antibody is a type of protein called gamma globulin

~gamma shaped

~4 polypeptide chain molecule
(2 light & 2 heavy polypeptide )

~Antibodies are classified into 5 types:-
(1)IgD
(2)IgG(1st Major)
(3)IgA(2nd major)
(4)IgM
(5)IgE

Details of IgD:-
———————–

Molecular wt.:-1,80,000 Daltons

Half life:-3 days

Serum concentration:-0.03 mg/ml

Physical State:-Monomer

Main Function:- Not known.

Details of IgG:-
———————–

Molecular wt.:-1,50,000 Daltons

Half life:-21 days

Serum concentration:-12 mg/ml

Physical State:-Monomer

Main Function:- Protects the body fluid.

Details of IgA:-
———————–

Molecular wt.:-1,60,000 Daltons

Half life:-6 days

Serum concentration:- 2 mg/ml

Physical State:-Monomer/Di/Polymer

Main Function:- Protects the body surface.

Details of IgM:-
———————–

Molecular wt.:-9,00,000 Daltons

Half life:-5 days

Serum concentration:-1.2 mg/ml

Physical State:-Pentamer

Main Function:- Protects the blood stream.

Details of IgE:-
———————–

Molecular wt.:-1,85,000 Daltons

Half life:-2 days

Serum concentration:-0.0004 mg/ml

Physical State:-Monomer

Main Function:- Mediates Type 1 hypersentivity.