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Biochemistry ( Part- 3 ) MCQs with Answers


1. A nucleoside consists of
(A) Nitrogenous base
(B) Purine or pyrimidine base + sugar
(C) Purine or pyrimidine base + phosphorous
(D) Purine + pyrimidine base + sugar + phosphorous

2. A nucleotide consists of
(A) A nitrogenous base like choline
(B) Purine + pyrimidine base + sugar +phosphorous
(C) Purine or pyrimidine base + sugar
(D) Purine or pyrimidine base + phosphorous

3. A purine nucleotide is

4. A pyrimidine nucleotide is

5. Adenine is
(A) 6-Amino purine
(B) 2-Amino-6-oxypurine
(C) 2-Oxy-4-aminopyrimidine
(D) 2, 4-Dioxypyrimidine

6. 2, 4-Dioxypyrimidine is
(A) Thymine
(B) Cystosine
(C) Uracil
(D) Guanine

7. The chemical name of guanine is
(A) 2, 4-Dioxy-5-methylpyrimidine
(B) 2-Amino-6-oxypurine
(C) 2-Oxy-4-aminopyrimidine
(D) 2, 4-Dioxypyrimidine

8. Nucleotides and nucleic acids concentration are often also expressed in terms of
(A) ng
(B) mg
(C) meq
(D) OD at 260 nm

9. The pyrimidine nucleotide acting as the high energy intermediate is

10. The carbon of the pentose in ester linkage with the phosphate in a nucleotide structure is
(A) C1
(B) C3
(C) C4
(D) C5

11. Uracil and ribose form
(A) Uridine
(B) Cytidine
(C) Guanosine
(D) Adenosine

12. The most abundant free nucleotide in mammalian cells is

13. The mean intracellular concentration of ATP in mammalian cell is about
(A) 1 mM
(B) 2 mM
(C) 0.1 mM
(D) 0.2 mM

14. The nucleic acid base found in mRNA but not in DNA is
(A) Adenine
(B) Cytosine
(C) Guanine
(D) Uracil

15. In RNA molecule ‘Caps’
(A) Allow tRNA to be processed
(B) Are unique to eukaryotic mRNA
(C) Occur at the 3’ end of tRNA
(D) Allow correct translation of prokaryotic mRNA

16. In contrast to eukaryotic mRNA, prokaryotic mRNA
(A) Can be polycistronic
(B) Is synthesized with introns
(C) Can only be monocistronic
(D) Has a poly A tail

17. The size of small stable RNA ranges from
(A) 0–40 nucleotides
(B) 40–80 nucleotides
(C) 90–300 nucleotides
(D) More than 320 nucleotides

18. The number of small stable RNAs per cell ranges from
(A) 10–50,000
(B) 50,000–1, 00,000
(C) 1, 00,000–10, 00,000
(D) More than 10 lakhs

19. Molecular weight of heterogenous nuclear RNA (hnRNA) is
(A) More than 107
(B) 105 to 106
(C) 104 to 105
(D) Less than 104

20. In RNA molecule guanine content does not necessarily equal its cytosine content nor does its adenine content necessarily equal its uracil content since it is a
(A) Single strand molecule
(B) Double stranded molecule
(C) Double stranded helical molecule
(D) Polymer of purine and pyrimidine ribonucleotides

21. The nitrogenous base present in the RNA Molecule is
(A) Thymine
(B) Uracil
(C) Xanthine
(D) Hypoxanthine

22. RNA does not contain
(A) Uracil
(B) Adenine
(C) Thymine
(D) Ribose

23. The sugar moiety present in RNA is
(A) Ribulose
(B) Arabinose
(C) Ribose
(D) Deoxyribose

24. In RNA molecule
(A) Guanine content equals cytosine
(B) Adenine content equals uracil
(C) Adenine content equals guanine
(D) Guanine content does not necessarily equal Its cytosine content.

25. Methylated purines and pyrimidines are Characteristically present in
(A) mRNA
(B) hnRNA
(C) tRNA
(D) rRNA

26. Thymine is present in
(A) tRNA
(B) Ribosomal RNA
(C) Mammalian mRNA
(D) Prokaryotic mRNA

27. The approximate number of nucleotides in tRNA molecule is
(A) 25 (B) 50
(C) 75 (D) 100

28. In every cell, the number of tRNA molecules is at least
(A) 10 (B) 20
(C) 30 (D) 40

29. The structure of tRNA appears like a
(A) Helix
(B) Hair pin
(C) Clover leaf
(D) Coil

30. Although each specific tRNA differs from the others in its sequence of nucleotides, all tRNA molecules contain a base paired stem that terminates in the sequence CCA at
(A) 3′Termini
(B) 5′ Termini
(C) Anticodon arm
(D) 53 ′′ -Termini

31. Transfer RNAs are classified on the basis of the number of base pairs in
(A) Acceptor arm
(B) Anticodon arm
(C) D arm
(D) Extra arm

32. In tRNA molecule D arm is named for The presence of the base:
(A) Uridine
(B) Pseudouridine
(C) Dihydrouridine
(D) Thymidine

33. The acceptor arm in the tRNA molecule has
(A) 5 Base pairs
(B) 7 Base pairs
(C) 10 Base pairs
(D) 20 Base pairs

34. in tRNA molecule, the anticodon arm Possesses
(A) 5 Base pairs
(B) 7 Base pairs
(C) 8 Base pairs
(D) 10 Base pairs

35. The T ψC arm in the tRNA molecule Possesses the sequence
(A) T, pseudouridine and C
(B) T, uridine and C
(C) T, dihydrouridine and C
(D) T, adenine and C

36. Double helical structure model of the DNA Was proposed by
(A) Pauling and Corey
(B) Peter Mitchell
(C) Watson and Crick
(D) King and Wooten

37. DNA does not contain
(A) Thymine
(B) Adenine
(C) Uracil
(D) Deoxyribose

38. The sugar moiety present in DNA is
(A) Deoxyribose
(B) Ribose
(C) Lyxose
(D) Ribulose

39. DNA rich in A-T pairs have
(A) 1 Hydrogen bond
(B) 2 Hydrogen bonds
(C) 3 Hydrogen bonds
(D) 4 Hydrogen bonds

40. In DNA molecule
(A) Guanine content does not equal cytosine content
(B) Adenine content does not equal thymine content
(C) Adenine content equals uracil content
(D) Guanine content equals cytosine content

41. DNA rich in G-C pairs have
(A) 1 Hydrogen bond
(B) 2 Hydrogen bonds
(C) 3 Hydrogen bonds
(D) 4 Hydrogen bonds

42. The fact that DNA bears the genetic information of an organism implies that
(A) Base composition should be identical from species to species
(B) DNA base composition should charge with age
(C) DNA from different tissues in the same organism should usually have the same base composition
(D) DNA base composition is altered with nutritional state of an organism

43. The width (helical diameter) of the double helix in B-form DNA in nm is
(A) 1 (B) 2
(C) 3 (D) 4

44. The number of base pair in a single turn Of B-form DNA about the axis of the molecule is
(A) 4
(B) 8
(C) 10
(D) 12

45. The distance spanned by one turn of Bform DNA is
(A) 1.0 nm
(B) 2.0 nm
(C) 3.0 nm
(D) 3.4 nm

46. In a DNA molecule the thymine concentration is 30%, the guanosine concentration will be
(A) 10%
(B) 20%
(C) 30%
(D) 40%

47. IN a DNA molecule, the guanosine content is 40%, the adenine content will be
(A) 10%
(B) 20%
(C) 30%
(D) 40%

48. An increased melting temperature of duplex DNA results from a high content of
(A) Adenine + Guanine
(B) Thymine + Cytosine
(C) Cytosine + Guanine
(D) Cytosine + Adenine

49. A synthetic nucleotide analogue, 4-hydro-xypyrazolopyrimidine is used in the treatment of
(A) Acute nephritis
(B) Gout
(C) Cystic fibrosis of lung
(D) Multiple myeloma

50. A synthetic nucleotide analogue, used in The chemotherapy of cancer and viral infections is
(A) Arabinosyl cytosine
(B) 4-Hydroxypyrazolopyrimidine
(C) 6-Mercaptopurine
(D) 6-Thioguanine


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