 Drugs used as Diuretics with MOAÂ
Drug – Acetazolamide
MOA – Inhibition of carbonic anhydrase in PCT
Urinary Electrolytes – ↑ Na+ ↑ K+ ↑↑ HCO3 –
Blood PH – Acidosis
Drug – Ethacrynic acid, furosemide, torsemide
MOA – Inhibition of Na+/K+/2Cl– cotransporter in TAL
Urinary Electrolytes ↑↑ Na+ ↑ K+ ↑ Ca2+ ↑ Mg2+ ↑ Cl–
Blood PH – Alkalosis
Drug – Hydrochlorothiazide, indapamide, chlorthalidone
MOA – Inhibition of Na+/Cl– cotransporter in DCT
Urinary Electrolytes – ↑ Na+ ↑ K+ ↑ Cl– ↓ Ca2+
Blood PH – Alkalosis
Drug – Amiloride, triamterene,spironolactone, eplerenone
MOA – Block Na+ channels, Block aldosterone
receptors in Collecting tubule
Urinary Electrolytes – ↑ Na+ (small) ↓ K+
Blood PH – Acidosis
