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Drugs used as Diuretics with MOA

 Drugs used as Diuretics with MOA 


Drug – Acetazolamide

MOA – Inhibition of carbonic anhydrase in PCT

Urinary Electrolytes – ↑ Na+ ↑ K+ ↑↑ HCO3 –

Blood PH – Acidosis


Drug – Ethacrynic acid, furosemide, torsemide

MOA – Inhibition of Na+/K+/2Cl– cotransporter in TAL

Urinary Electrolytes ↑↑ Na+ ↑ K+ ↑ Ca2+ ↑ Mg2+ ↑ Cl–

Blood PH – Alkalosis


Drug – Hydrochlorothiazide, indapamide, chlorthalidone

MOA – Inhibition of Na+/Cl– cotransporter in DCT

Urinary Electrolytes – ↑ Na+ ↑ K+ ↑ Cl– ↓ Ca2+

Blood PH – Alkalosis


Drug – Amiloride, triamterene,spironolactone, eplerenone

MOA – Block Na+ channels, Block aldosterone
receptors in Collecting tubule

Urinary Electrolytes – ↑ Na+ (small) ↓ K+

Blood PH – Acidosis

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