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pharmacy Topic wise MCQs

General Pharmacology MCQs with Answers

General Pharmacology MCQs

1. Which of the following reaction is not involved in detoxification of drugs ?
a. Cytochrome oxidase
b. Cytochrome P450
c. Methylation
d. Sulfate conjugation

2. ED50 is a measure of :
a. Toxicity
b. Safety
c. Potency
d. Efficacy

3. Therapeutic index for a drug is a measure of :
a. Safety
b. Potency
c. Efficacy
d. Toxicity

4. Phase II drug trials are done to find :
a. Efficacy
b. Lethal dose
c. Maximal tolerated dose
d. Safety index

5. Forced Alkaline Diuresis of Alkanization of urine is used in Poisoning with :
a. Barbiturates
b. Amphetamina
c. Alcohol
d. Datura

6. G6PD enzyme deficiency does not cause hemoly- sis in treatment with :
a. Quinine
b. Pyrimethamine
c. Chloroquine
d. Primaquine

7. Which one of the following antiplatelet is a prodrug:
a. Aspirin
b. Dipyridamole
c. Ticlopidine
d. Abciximab

8. In unconjugated hyperbilirubinemia, the risk of kernicterus increases with the use of :
a. Ceftriaxone
b. Phenobarbitone
c. Ampicillin
d. Sulphonamide

9. A highly ionized drug :
a. Is excreted mainly by the kidney
b. Can cross the placenta easily
c. Is well absorbed from the intestine
d. Accumulates in the lipids

10. In which of the following phases of clinical trial of drug ethical clearance is not required?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV

11. The extent to which ionisation of a drug takes place is dependent upon pKa of the drug and the pH of the solution in which the drug is dissolved. Which of the following statements is not correct :
a. pKa of a drug is the pH at which the drug is 50% ionized
b. Small changes of pH near the pKa of a weak acidic drug will not affect its degree of ionization
c. Knowledge of pKa of a drug is useful in predict- ing its behaviour in various body fluids
d. Phenobarbitone with a pKa of 7.2 is largely ion- ized at acid pH and will be about 40% nonionised in plasma

12. Presence of food might be expected to interfere with drug absorption by slowing gastric empty- ing. or by altering the degree of ionisation of the drug in the stomach. Which of the following state- ments is not correct example :
a. Absorption of digoxin is delayed by the presence of food
b. Concurrent food intake may severely reduce the rate of absorption of phenytion
c. Presence of food enhances the absorption of hydrochlorthiazide
d. Antimalarial drug halofantrine is more extensively absorbed if taken with food

13. All of the following statements regarding bioavailability of a drug are true except :
a. It is the proportion (fraction) of unchanged drug that reaches the systemic circulation
b. Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve (0-α. after oral and intravenous(iv) administration
c. Low oral bioavailability always and necessarily mean poor absorption
d. Bioavaialabilty can be determined from plasma concentration or urinary excretion data

14. Regarding efficacy and potency of a drug, all are true, except :
a. In a clinical setup, efficacy is more important than potency
b. In the log dose response curve, the height of the curve corresponds with efficacy
c. ED50 of the drug corresponds to efficacy
d. Drugs that produce a similar pharmacological effect can have different levels of efficacy

15. True statement regarding first order kinetics is :
a. Independent of plasma concentration
b. A constant proportion of plasma concentration is eliminated
c. T ½ increases with dose
d. Clearance decreases with dose

16. All are reasons for reducing drug dosage in eld-erly except :
a. They are lean and their body mass is less
b. Have decreasing renal function with age
c. Have increased baroceptor sensitivity
d. Body water is decreased

17. True statement regarding inverse agonists is :
a. Binds to receptor and causes intended action
b. Binds to receptor and causes opposite action
c. Bind to receptor and causes no action
d. Bind to receptor and causes submaximal

18. All are pharmacogenetic conditions, except :
a. Adenosine deaminase deficiency
b. Malignant hyper-pyrexia
c. Coumarin insensitivity
d. G6PD deficiency

19. Which of the following is true :
a. As the concentration of drug increases over the therapeutic range, the bound form of the drug increases
b. The bound form is not available for metabolism but is available for excretion
c. Acidic drug binds to albumin; and basic drug binds β globulin
d. Binding sites are non-specific and one drug can displace the other

20. True about teratogenicity of a drug is all except :
a. It is genetically predetermined
b. Environment influences it
c. Related to the dose of the teratogenic drug
d. Affects specially at a particular phase of devel- opment of foetus

21. Which of the following is not an example of cyto- chrome p450 dehydrogenase inducer :
a. Phenobarbitone
b. Rifampicin
c. Phenytoin
d. Ketoconazole

22. Drug, which is contraindicated in pregnancy is:
a. Tetracycline
b. Erythromycin
c. Ampicillin
d. Chloroquine

23. Which drug is not acetylated ?
a. NH
b. Dapsone
c . Hydralazine
d. Metoclopropamide

24. Which is a prodrug ?

  1. a. Enalapril
  2. c. Captopril
  3. b. Clonidine
  4. d. Lisinopril

25. Loading dose depends on :
a. Volume of distribution
b. Clearance
c. Rate of administration
d. Half life

26. Which is CPY P450 inhibitor ?
a. Ketoconazole
b. Rifampicin
c. Phenytoin
d. INH

27. Therapeutic monitoring is done for all of the fol- lowing except :
a. Tacrolimus
b. Metformin
c. Cyclosporine
d. Phenytoin

28. Good clinical practices (GCPs) are not a part of :
a. Preclinical studies
b. Phae I studies
c. Phase II studies
d. Phase IV studies

29. The following are contraindicated in pregnancy except :
a. Sodium nitroprusside
b. Labetalol
c. Spironolactone
d. ACE inhibitors

30. The following drug is contraindicated in pregnancy:
a. ACE inhibitor
b. Calcium channel blocker
c. Beta blocker
d. Penicillin

31. Maternal carbimazole intake causes all except :
a. Choanal atresia
b. Cleft lip and cleft palate
c. Fetal goitre
d. Scalp defects

32. Loading dose depends on :
a. Half life
b. Plasma volume
c. Volume of distribution
d. Rate of clearance

33. Which of the following is a prodrug ?
a. Clonidine
b. Enalapril

c. Salmeterol
d. Acetazolamide

34. Drugs undergoing acetylation include except :
a. Dapsone
b. Metoclopramide
c. Procainamide
d. INH

35. Side effects of a drug arise due to the interactions of the drug of molecules other than the target. These effects of a drug can be minimized by its high :
a. Specificity
b. Affinity
c. Solubility
d. Hydrophobicity

36. Which of the following property of drug will enable it to be used in low concentrations :
a. High affinity
b. High specificity
c. Low specificity
d. High stability

37. Which of the following drugs can be safely pre- scribed in pregnancy ?
a. Warfarin
b. ACE inhibitors
c. Heparin
d. β – blockers

38. Km of an enzyme is :
a. Dissociation constant
b. The normal physiological substrate concentra- tion
c. The substrate concentration at half maximal ve- locity
d. Numerically identical for all isozymes that cata- lyze a given reaction

39. For drugs with first order kinetics the time required to achieve steady state levels can be predicted from :
a. Volume of distribution
b. Half life
c. Clearance
d. Loading dose

40. All of the following drugs are metabolised by acetylation except :
a. INH
b. Sulfonamides
c. Ketoconazole
c. Hydralazine

41. The lymphocytopenia seen a few hours after ad- ministration of a large dose of prednisone to a patient with lymphocytic leukemia is due to :
a. Massive lymphocytic apoptosis
b. Bone marrow depression
c. Activation of cytotoxic cells
d. Stimulation of natural killer cell activity

42. The substrate concentration used for determin- ing the activity of an enzyme having Km=x μm will be:
a. 2xμm
b. 4xμm
c. 8xμm
d. 10xμm

43. Racemic mixture of two enantiomers with different pharmacokinetic and pharmacodynamic prop- erties is seen in :
a. Dilantin
b. Digoxin
c. Verapamil
d. Octreotide

44. A drug is more likely to cause toxicity in elderly patients due to all of the following reasons except:
a. Decreased renal excretion of drugs
b. Decreased hepatic metabolism
c. Increased receptor sensitivity
d. Decreased volume of distribution

45. Which of the following can be given with dose adjustment :
a. Levodopa + metoclopramide
b. Gentamicin + Furosemide
c. Ferrous sulphate + Tetracycline
d. Clonidine + Chlorpromazine

46. Alcohol intake during pregnancy causes, all, except :
a. Brachycephaly
b. Microcephaly
c. Hyperkinetic movements
d. Congenital anomalies

47. New drug study and development can be done by:
a. Pharmacogenetics
b. Molecular modelling
c. Pharmacolibrary
d. Neopharmacy

48. Concentration of a drug in blood is 40 microgm/ ml. Dose of the drug is 200mg. Volume of distribution of the drug assuming minute elimination is :
a. 5 litre
b. 0.5 litre
c. 2.5 litre
d. 3 litre

49. All of the followings can cause hemolytic anaemia except :
a. Isoniazid
b. Rifampicin
c. Co – trimoxazole
d. Propranolol

50. A drug X has affinity to bind with albumin and Y has 150 times more affinity to bind with albumin than X. TRUE statement is :
a. Drug X will available more in tissues
b. Drug Y will be more available in tissues
c. Free conc. of drug X in blood will be more
d. Toxicity of Y will be more

Answers

  1. a. Cytochrome …
  2. c. Potency
  3. a. Safety
  4. a. Efficacy
  5. a. Barbiturates
  6. b. Pyrimethamine
  7. c. Ticlopidine
  8. d. Sulphonamide
  9. a. Is excreted …
  10. d. Phase IV
  11. b. Small changes …
  12. c. Presence of…
  13. c. Low oral
  14. c. ED50 of …
  15. b. A constant …
  16. c. Have …
  17. b. Binds …
  18. a. Adenosine …
  19. d. Binding …
  20. a. It is genetically …
  21. d. Ketocon …
  22. a. Tetracycline
  23. d. Metoclopropa …
  24. a. Enalapril
  25. a. Volume …
  26. a. Ketoconazole
  27. b. Metformin
  28. a. Preclinical …
  29. b. Labetalol
  30. a. ACE …
  31. b. Cleft …
  32. c. Volume …
  33. b. Enalapril
  34. b. Metoclopra …
  35. a. Specificity
  36. a. High …
  37. c. Heparin
  38. c. The substrate …
  39. b. Half life
  40. c. Ketoconazole
  41. a. Massive …
  42. a. 2xμm
  43. c. Verapamil
  44. d. Decreased …
  45. c. Ferrous …
  46. a. Brachycephaly
  47. b. Molecular …
  48. a. 5 litre
  49. d. Propranolol
  50. a. Drug X …

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