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pharmacyPharmacy Exams

Notes Of Minerals

MINERALS

DEFINITION :

“A mineral is a chemical element required as an essential nutrient by organism to perform function necessary for life”.

OR

“Minerals are inorganic substances required by the body in small amounts for a variety of different function”.

Classification:

1) Major Elements:

• These are also known as “Macrominerals”.
• It is required in amount > 100 mg/day.
• Atleast 5 gram of the mineral present in the body.
• Eg – Calcium , Sodium , Potassium , Chloride , Phosphorous , Magnesium , Sulphur , Fluoride

2) Minor Elements:

• These are also known as “Microminerals”.
• It is required in amount < 100 mg/day.
• Less than 5 gram of total mineral present in the body.
• Eg – Iron , Zinc , Copper , Selenium , Chromium , Iodide , Manganese , Molybdenum

3) Necessary:

• It is necessary for the body but their exact function are not known.
• Eg – Chromium , Nickel , Bromide , Lithium , Barium

4)Non-Essential:

• Seen in tissues.
• Contaminant in food stuffs.
• Eg – Rubedium , Silver , Gold , Bismuth

5) Toxic:

• It is should be avoided.
• Eg – Aluminium , Cadmium , Mercury

Major minerals:

Calcium –

Chemical formula : (Ca2+)
Sources :
Dairy products , Fish with bones , Tofu , Leafy green vegetables , legumes , Fortified foods , yogurt , cheese , salmon , sardiness

Daily Requirement : 1000 mg

Function:
a) Development of bones and teeth
b) Transmission of nerve impulses
c) Blood clotting
d) Normal heart action
e) Normal muscle action

Deficiency:
Children – Stunted growth
Adults – Osteoporosis

Toxic effects:
• Diarrhoea
• Interference with absorption of other minerals

Sodium –

Chemical formula : (Na+)

Sources : Table salt . soy sauce , MSG , all processed foods

Daily Requirement : 2400 mg

Function:
a) Maintains normal fluid and electrolytes balance
b) Assists nerve impulse transmission
c) Muscle contraction

Deficiency:
• Muscle cramps
• Mental apathy
• Loss of appetite

Toxic effects:
• Edema
• Acute hypertension
• Increased calcium excretion

Potassium –

Chemical formula : (K+)

Sources :Fresh vegetables , Bananas , Citrus food , Milk , Meats , Fish

Daily Requirement : 3500 mg

Function:
a) Maintain normal fluid and electrolyte balance
b) Assist nerve impulse transmission
c) Muscle contraction

Deficiency:
• Muscular weakness
• Paralysis
• Confusion due to dehydration

Toxic effects:
• Muscular weakness
• Vomiting reflex

Chloride –

Chemical formula : (Cl-)

Sources : Table salt , Eggs , Seafood , Milk

Daily Requirement : 3400 mg

Function:
a) Gastric acidity
b) Regulates acid-base balance in the body
c) Maintains fluid & electrolyte balance
d) Formation of hydrochloric acid

Deficiency:
• Imbalance in gastric acidity
• Imbalance in blood pH

Toxic effects:
• Exhaustion
• Nausea

Phosphorous

Chemical formula : (P)

Sources : Fish , Poultry , Eggs , Milk , Meat , Cheese , Lean , Legumes , Nuts , Whole-Grains cereals

Daily Requirement : 1000 mg

Function:
a) Development of bones & teeth
b) Maintains normal pH of the blood
c) Constituent of all body cells
d) CHO , CHON & fat metabolism

Deficiency:
• Weakness
• Bone pain

Toxic effects:
• Low blood calcium
• Increased calcium excretion

Magnesium 

Chemical formula : (Mg2+)

Sources : Nuts , Legumes , Whole grains , Dark leafy greens , seafood , Chocolate , Cocoa

Daily Requirement : 350 mg

Function:
a) Mineralization of bones & teeth
b) It helps enzymes function
c) Muscle contraction
d) Nerve transmission

Deficiency:
• Weakness
• Muscle twitches
• Confusion
• Convulsion
• Bizarre muscle movements

Toxic effects:
• Confusion
• Lack of muscle coordination
• Death

TRACE ELEMENTS :

Iron –

Chemical Formula: (Fe+)
Sources: Red meats , Fish , Poultry , Eggs , Legumes , Dried fruits , Shellfish , Liver , Whole grains or enriched breads & cereals , Dark green & leafy vegetables , Molasses

Diet requirements: 15mg

Functions:
a) Transports oxygen & carbon dioxide
b) Hemoglobin formation
c) Component of cellular enzymes essential for energy production

Deficiency:
• Anaemia
• Weakness
• Headaches

• Reduced immunity
• Low cold tolerance

Toxic effects:
• Infection
• Fatigue
• Liver damage
• Colon cancer
• Bloody stools
• Fatal to kids

Zinc

Chemical Formula: (Zn+)

Sources: Seafood , Eggs , Milk , Legumes , Wheat bran , Esp. oysters

Daily Requirements: 15 mg

Functions:
a) Formation of collagen
b) Wound healing
c) Taste acuity
d) Essential for growth
e) Immune reaction

Deficiency:
• Failure to grow
• Dermatitis
• Loss of taste
• Poor healing
• Sex retardation

Toxic effects:
• Nausea
• Fever

• Vomiting
• Dizziness
• Uncoordinated
• Anaemia
• Heart disease

Copper

Chemical Formula: (Cu)

Sources: Poultry , Shellfish , Legumes , Whole grain breads , Cereals

Diet requirement: 2 mg

Functions:
a) Facilitates the function of many enzymes
b) Iron may be an integral part of DNA & RNA molecule

Deficiency:
• Pallor
• Retarted growth
• Edema
• Anorexia

Toxic effects:
• Wilson’s disease
• Deterioration of neurological process

Selenium

Chemical Formula: (Se+6)

Sources: Seafoods , Meats , Grains , Vegetable depending on soil content , Whole grains , Cereals

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Diet requirement: 35 μg

Functions: 

a) Antioxidants
b) Works with Vitamin E

Deficiency:
• Keshan disease
• Muscle pain / degradation
• Cataracts
• Low sperm
• Fragile RBCs
• Heart damage

Toxic effects:
• Muscle damage
• Nail & Hair brittleness
• Loss nerve
• Liver damage
• Nausea

Chromium

Chemical Formula: (Cr)

Sources: Meat , Whole grains , Vegetable oils

Diet requirement: 120 μg

Functions:
It helps insulin move glucose from blood into cells

Deficiency:
Abnormal glucose metabolism

Toxic effects:
Possible muscle degeneration

Iodine 

Chemical Formula: (I2)

Sources: Iodized salt , Seafood , Plant grown in Iodine rich soil

Diet requirement: 150 μg

Functions:
a) A component of thyroid hormone – helps to regulate growth , development , metabolism.
b) Regulation of basal metabolic rate

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Deficiency:
• Goiter
• Cretinism
• Myxedema

Toxic effects:
• Low thyroid activity
• Enlarged thyroid

Manganese 

Chemical Formula: (MnO2)

Sources: Whole grains , Nuts , Fruits , Vegetable

Diet requirement: 5 mg

Functions:
Enzyme function

Deficiency:
• Impaired growth
• Skeletal abnormalities
• Neonatal ataxia

Toxic effects:
• In extremely high exposure from contamination 
• Severe psychiatric & neurologic disorder

Molybdenum

Chemical Formula: (Mo+2)

Sources:
Whole grains , Organ meat , Peas , Beane

Diet requirement: 75 μg

Functions:
Energy metabolism

Deficiency:
• Brain abnormalities
• Developmental delays
• Childhood death
• It’s extremely rare

Toxic effects:
Gout like syndrome

Fluoride

Chemical Formula: (F-)

Sources: Fluoridated water , Seafood , Tea

Diet requirement: 3-5 mg

Functions:
a) Helps to make bones & teeth stronger
b) Increase resistance to tooth decay

Deficiency:
• Susceptibility to tooth decay
• Possibly osteoporosis

Toxic effects:
• Chest pain
• Fluorosis
• Discolored teeth
• Nausea