PRE-GPAT MOCK TEST
1. Reserpine on hydrolysis gives:
(a) Reserpicacid + Methylalcohol +Trimethoxy cinnamic acid
(b)Reserpic acid + Acetic acid + Trimethoxy benzaldehyde
(c) Reserpicacid + Methylalcohol +Trimethoxy benzoic acid
(d)Reserpic acid + Methylalcohol +Trimethoxy Cinnamaldehyde
2. Salbutamol sulphate IP is assayed by
(a) Direct titration with standard sodium hydroxide solution
(b) Direct titration with standard sodium hydrochloric acid
(c) A known amount of standard acid is added and excess is titrated with standard alkali
(d) Dissolve in glacial acetic acid and titrated with standard perchloric acid using oracet blue.
3. Powder ergot when treated with sodium hydroxide solution develops?
(a) A strong odour of ammonia
(b)A strong odour of trimethyl
(c) A strong odour of indole
(d)A strong odour of urea
4. For the registration of pharmacist in the various states, the Pharmacy Act provide for the constitution of:
(a) Registration of tribunals
(b) Registrar of Co-operative societies
(c) Registrar of state pharmacy council
(d)Registrar of central pharmacy council
5. Powder digitalis is dried at temperature
(a) Not exceeded 60 ºC
(b) 65 ºC
(c) 75 ºC
(d) 100 ºC
6. Prazepam differ in structure from diazepam by
(a) N- methyl group
(b) N –cyclopropyl group
(c) N-cyclopropyl methyl group
(d) N-propyl group
7. The mechanism of action of rifampicin involve
(a) Inhibition of bacterial DNA directed RNA polymerase
(b) Inhibition of mycolicacid synthesis
(c) Inhibition of protein synthesis
(d) Inhibition of transpeptidase
8. The volume of did tribution of drugs is
(a) An expression of total body volume
(b)A measure of total fluid volume
(c) A relationship between the total amount of drug in the body and the concentration of the drug in the blood
(d)Proportional to bioavailability of the drug
9. Resolution of a spectrophotometer is
(A) It’s a wavelength range
(B) Its ability to distinguish adjacent absorption bands
(C) it’s a capacity for its continuous use
(D) Its power to gather light according to source
10. Glandular hair growing having a unicellular or occasionally a short uniserate pedicel with a unicellular orbicellular terminal glandis characteristics of
(a) Senna leaves
(b) Belladonna leaves
(c) Datura stramonium leaves
(d)Digitalis Purpurea leaves
11. Skeletal muscle relaxant produced by the drug ______is effectively antagonized by neostigmine
(a) Diazepam
(b)Succinylcholine
(c) Tubocurarine
(d)Aminophylline
12. Vitamin D2
(a) 22, 23-Dihydro -5,6cis –Ergocalciferol
(b) 5, 6 cis- chlorcalciferol
(c) 7- Dehydrocholesterol
(d) 21,24 – dihydro 5,6 cis Ergocalciferol
13. R.W. C. is used to identify the strength of?
(a) Antibiotics
(b)Antipyretics
(c) Antiseptic
(d)Antiinflammatory
14. The essential structural unit for the anthelmentics activity of mebendazole is
(a) Benzoyl group
(b)Benzimidazole
(c) Methyl carbamates
(d) Imidazole
15. The anticoagulant activity of heparin sodium injection IP is estimated using:
(a) Female rats
(b) Male rats
(c) Rabbits
(d) Sheep
16. Infrared spectroscopy is a convenient method for understanding of
(a) Drug receptor interaction
(b) Functional group identification
(c) Physiochemical properties
(d) Conformational properties
17. Most commonly used amtimicrobial agent for intraperitoneal dialysisis
(a) Chlorocresol
(b) Benzalkonium chloride
(c) Isopropyl alcohol
(d) None of the above
18. In the steroid nucleus, they are
(a) Six chiral center with nucleus i.e. 5,8,9,10,13, and 14
(b) Seven chiral center with nucleus i.e. 3,8,9,10,11, 12 and 14
(c) Six chiral center with nucleus i.e. 3,8,9,10,11, and 12
(d) Six chiral center with nucleus i.e. 5,7,9,10,13, and 16
19. Sulphomethoxazoleis an antibacterial drug. It is a
(a) Short acting drug
(b) Short and intermediate acting drugs
(c) Long acting drugs
(d)Mixed acting drugs
20. Wavenumber is the number of waves
(a) Per second
(b) Per centimeter
(c) Per inch
(d) Per cm3
21. The raw material for synthesis of propranolol is
(a) α – Naphthylamine
(b) β napthol
(c) α-naphthol
(d) 1- nepthaldehyde
22. All the statement mentioned below about choral hydrate is true EXCEPT that it
(a) Produces hypnosis
(b) Produces analgesia
(c) Produce dependence
(d) Irritate gastric mucosa
23. Which is ideal combination for testing the solubility of an enteric coated capsule in alkaline medium?
(a) Sodium bicarbobnate + Potassium hydroxide + Pepsin
(b) Sodiumbicarbobnate + Sodiumtauroglycocholate+Papain
(c) Sodium bicarbobnate +Pancreatin +Sodium tauroglycocholate
(d)Sodiumbicarbobnate + Billirubin
24. Oxazepam is used in relief of psychoneurosis. It has lower incidents of side Effects and reduced toxicity due to
(a) N-demethylation
(b) Ring oxidation
(c) Aromatic hydroxylation
(d) Conjugation of 3- hydroxyl group
25. One of the detectors used in gas chromatography
(a) Bolometer
(b) Thermal conductivity detector
(c) Golay detectors
(d) Geiger Counter
26. Alkloids in cinchona bark are detected by
(a) Iodine test
(b) Thalleioquin test
(c) Liebermann –burchard test
(d) Nessler’s test
27. 2- amino -5-chorbenzophenone is the convenient starting material for the synthesis of
(a) Nitrazepam
(b) Diazepam
(c) Chloramphenicol
(d)Trimethoprim
28. Side effect of Chloramphenicol is?
(a) Gray-baby syndrome
(b) Jaundice
(c) Discolouration of teeth
(d) Obesity
29. Papaverine is
(a) 6, 7 – dimethoxy -1- (3’, 4’ – dimethoxybenzyl) isoquinoline
(b) 6, 7 – dimethoxy -1- (3’, 4’ – dimethyl benzyl) isoquinoline
(c) 6, 7 – dimethoxy -1- (3’, 4’ – dimethoxybenzyl) quinoline
(d) 6, 7 – dimethoxy -1- (3’, 4’ – dimethyl benzyl) quinoline
30. Cortisone is
(a) 4 – Pregnane-12 α, 21 diol- 3, 20- Dione
(b) 4 – Pregnane-17 α, 21 diol- 3, 11, 20- trione
(c) 4 – Pregnane-16 α, 21 diol- 3, 11, 20- trione
(d) 4 – Pregnane-17 α, 21 diol- 3, 11, – Dione
31. Pregnenolone, an intermediate in synthesis of steroids, on oppeneur oxidation gives
(a) Progesterone
(b) 9α – flurocortisone
(c) Triamcinolone
(d) α methyl Prednisolone
32. Carbamazepine is tricyclic antidepressant, it is classified as
(a) Benzodiazepine
(b) Arylalkonolamine
(c) Iminostilbene
(d) Benzimidazole
33. Sulfa drugs can be conveniently estimated using the reagent
(a) 4, 4 Dithiobis – (2-nitrobenzoic acid)
(b) Tris-(hydroxyl methyl) amino methane sodium nitrate
(c) N-(1-nepthyl) ethylenediamine
(d) N-ethylmalcimide
34. Testosterone can be commercially synthesis from
(a) Sarsapogenin
(b) Mexogenin
(c) Oubagenin
(d) Halotensin
35. Ehlrich’s reagent is
(a) Bismuth iodide solution
(b) p-dimethyl aniline solution in alcohol
(c) p-dimethyl amino benzaldehyde solution
(d) p-dimethyl aniline solution in alcohol
36. The neurotransmitter is release the sympathetic nerve fiber is
(a) Epinephrine
(b) Norepinephrine
(c) Acetylcholine
(d) Physostigmine
37. Resolution of monochromator is the ability to distinguish
(a) As aseparate entities adjacent spectral features
(b) Separation of different colours
(c) Separation of UV light and Visible light
(d) Dispersing Characteristics
38. Important activity noticed in testosterone
(a) Androgenic, Myotropic and Anabolic
(b) Progestinal, Myotropic and Anabolic
(c) Estrogenic, Myotropic and Anabolic
(d) Androgenic, Optometric and Catabolic
39. Amygdalin on hydrolysis gives
(a) Mendelonitrile +Benzaldehyde
(b) Mendelonitrile + Benzaldehyde +Glucose
(c) Mendelonitrile +Glucose
(d)Mendelonitrile + Benzaldehyde +Rhamanose
40. The presence of unpaired electron in metalion complex meant for special analysis is called
(a) Paramagnetic (b) Dimagnetic (c) Bimagnetic (d) Unimagnetic
41. The ilkovic equation in the polarographic measurements is given by
42. The stationary phase in TLC is
(a) Adsorbent
(b) Liquid held between glass plate and adsorbent
(c) Glass plates
(d) None of the above
43. Digoxin
(a) Has its action terminated by metabolism in the liver
(b) Has a plasma t1/2 of 6 hours
(c) Should be given half of its normal dose to hypothyroid patients
(d) Provide benefit in atrial fibrillation by increasing the force of contraction
44. Drug used in treatment of bronchial asthma usually
(a) Block both α and β adrenergic receptors
(b) Stimulate α receptors but block β receptor.
(c) Stimulate β receptors but block α receptor.
(d) Stimulate α and / or β receptors
45. Vinca alkaloids are isolated from
(a) Catharanthus roseus and contain indole and indolinemoieties
(b) Rosco chromogens and contain indole and indolinemoieties
(c) Catharanthus roseus and contain quinoline and quinaldine moieties
(d) Catharanthus indicus and contain indole and quinoline moieties
46. All of the following physicochemical constants are useful in predicting the solubility of a Drug except?
(a) Dielectric constants
(b) pH of a solution
(c) pKa of the drug
(d) Valency
47. The 5β pregnane is said to have a
(a) trans-anti-trans-anti-trans back bone
(b) cis-anti-trans-anti-trans back bone
(c) cis-syn-trans-syn-trans back bone
(d) trans-anti-cis-anti-cis back bone
48. In the stable conformation of 5 α -pregnane
(a) Rings A, B, C are in boat conformation
(b) Rings A and B are in boat while C in chair conformation
(c) Ring A is in boat while Band C in chair conformation
(d) All the three rings are in chair conformation
49. In case of hypothyroidism, the preferred thyroid preparation is
(a) Levothyroxine
(b) Dextrothyroxine
(c) Leothyroxine
(d) None of the above
50. D-Fructose on simple reduction gives
(a) L-Fructose
(b) Only Sorbitol
(c) Mannitol
(d) Mixture of Mannitol and Sorbitol
Answers
