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Acetate Pathways:- Hand Written Notes


The acetate pathway is important in the formation of various important
phytoconstituents like fatty acids, polyketides, prostaglandins, aflatoxin, tetracycline and other various important phytoconstituents. For the biosynthesis of fatty acid, the acetyl CoA
carboxylated to form malonyl CoA by the presence of enzyme named acetyl CoA
carboxylase. The energy requisite for this carboxylation is supplied by ATP and loss of CO2 occurs. After this step reduction, dehydration and again reduction will occur. During both
reductions process the electron is provided by NADH+ and H+ and the formation of butyryl ALP will occur. The coupling between malonyl ALP and butyryl ALP will occur and their reduction is repeated again for whole chain. Malonyl CoA bind again with the fatty acid residue by increase the chain with two carbon unit. The first end product is palmitic acid which has 16 carbon atoms. The chain is further elongated by various mechanisms.