Autacoids and related Drugs
Pharmacology of Drugs Acting on Urinary System
1. Agents which have limited activity on local area is termed as-
(A)Autacoids
(B) Hormones
(C) Enzymes
(D)All of the above
2. Histamine is released from
(A)Parietal cell
(B) Mast cell
(C) Goblet cell
(D)All of the above
3. Which of the following is location of non-mast cell histamine
(A)Brain
(B) Epidermis
(C) Gastric mucosa
(D)All of the above
4. Histamine effect on bronchial smooth muscle
(A)Contraction
(B) Relaxation
(C) No effect
(D)Contraction and then Relaxation
5. Histamine affect which receptor to stimulate gastric acid secretion
(A)H1
(B) H2
(C) H3
(D)H4
6. Which of the following drug does not produce drowsiness as compare to 1st generation antihistaminic drugs
(A)Cetirizine
(B) Levo- Cetirizine
(C) Diphenhydramine
(D)Both A and B
7. Which of the following is/are example of eicosanoid
(A)Prostaglandin
(B) Prostacyclin
(C) Thromboxane
(D)All of the above
8. Paracetamol generally affect which of the following type of COX
(A)COX-1
(B) COX-2
(C) COX-3
(D)None of the above
9. Angiotensinogen is synthesized in
(A) Liver
(B) Kidney
(C) Brain
(D) Heart
10. Substance P has following number of amino acids
(A)10
(B) 11
(C) 12
(D)13
11. NSAID drugs have following action
(A)Analgesic
(B) Anti-Pyretic
(C) Anti-Inflammatory
(D)All of the above
12. Which of the following is side effect of NSAID
(A)Gastric erosion
(B) Peptic ulcer
(C) Initiation of bleeding
(D)All of the above
13. Acetaminophen is also known as
(A)Paracetamol
(B) Aceclophanc
(C) Nimusulide
(D)Aspirin
14. The side effect of NSAID in most of the case is generally associated with
(A)Inhibition of COX-1
(B) Inhibition of COX-2
(C) Inhibition of COX-3
(D)All of the above
15. Gout is an example of
(A)Metabolic acidosis
(B) Metabolic disorder
(C) Genetic disorder
(D)None of the above
16. The cause of gout is
(A)Over synthesis of uric acid
(B) Over synthesis of insulin
(C) Saturation of uric acid in blood
(D)Both A and C
17. Agent which increase elimination of uric acid via urine is called as
(A)Uricosouric agents
(B) Purine synthesis inhibitor
(C) Leukocyte inhibitor
(D)Antidiuretic
18. Colchicine MOA is
(A)Inhibition of Leukocyte migration
(B) Inhibition of Phagocytosis
(C) Inhibition of Xanthine oxidase
(D)Both A and B
19. Osteoarthritis is result of
(A)Physical work load
(B) Autoimmune disorder
(C) Genetic disorder
(D)Metabolic disorder
20. Rheumatic Arthritis cause is
(A)Autoimmune disorders
(B) Injury
(C) Genetics
(D)None of the above
