Autocoids important Question For One Mark
True or False
1) The word autocoids derive its origin from the Latin word.
2) Histamine is an oxygen-containing organic compound.
3) H1 antagonists were termed as antihistamines.
4) Angiotensin is a potent vasodilator substance produced in plasma.
5) The H4 antagonists are found in haemopoietic cells and intestines.
6) The actions of AT-II are inhibited at the AT1 receptor by AT1 inhibitor antagonists
7) Bradykinin exists in its inactive form in the plasma.
Fill in the Blanks
8) _________ are chemical substances that are produced within the cells and are released in response to different stimuli to cause various phy siological actions.
9) Histamine is a ____________ organic compound belonging to the group of amines.
10) H1 antagonists were termed as _____________.
11) 5-Hydroxytyrptamine or 5-HT is commonly known as _______ due to its ________.
12) The term prostaglandin is derived from _______________.
13) ___________ is a potent vasopressor substance produced in plasma.
14) ___________ exists in its inactive form in the plasma.
15) ____________ is a NK1 receptor antagonist which is orally administered.
Answers
1) False 2) False 3) True 4) False 5) True 6) True 7) True 8) Autocoids 9) Nitrogen-containing 10) Antihistamines 11) Serotonin, Vasoconstrictor activity 12) Prostate gland 13) Angiotensin 14) Bradykinin 15) Aprepinant
Important Summary For one mark Question
1) The word autocoids derive its origin from the Greek words autos meaning self and akos meaning healing element.
2) Autocoids are chemical substances that are produced within the cells and are released in response to different stimuli to cause various physiological actions.
3) Histamine is a nitrogen -containing organic compound belonging to the group of amines.
4) H1 antagonists were termed as antihistamines.
5) Thioperamide and clobenpropit have been identified as H 3 receptor antagonists.
6) The H4 antagonists are found in haemopoietic cells (mast cells, basophils, and eosinophils) and intestines.
7) 5-Hydroxytyrptamine or 5 -HT (a monoamine neurotransmitter) is commonly known as serotonin due to its vasoconstrictor activity.
8) The term prostaglandin is derived from prostate gland (their first site of origin ).
9) Prostaglandins form a group of structurally -related lipid compounds and perform many important functions in animals.
10) Angiotensin is a potent vasopressor substance produced in plasma.
11) Angiotensinogen is converted to AT -I by renin, which is formed in the kidneys in the juxtaglomerular apparatus (JG apparatus).
12) Angiotensin-II acts on the vascular smooth muscles, adrenal cortex, kidneys, heart, and brain.
13) The actions of AT -II are inhibited at the AT 1 receptor by AT 1 inhibitor antagonists (e.g., losartan and valsartan).
14) Bradykinin exists in its inactive form in the plasma. It is made up of bradykininogen (the 2-globulin precursor) by the plasma enzyme kallikrein.
15) Substance P is a peptide which belongs to the tachykinin family of peptides.
16) Neurokinin A and B are other members of tachykinin family.
17) Aprepitant is a NK1 receptor antagonist which is orally administered.
