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Non-Steroidal Anti-Inflammatory Agents (Short Question)

Non-Steroidal Anti-Inflammatory Agents important Question For One Mark 

True of False

1) Aspirin is used to inhibit the clotting of blood.
2) Phenylbutazone is quickly and wholly absorbed from the GIT and reaches the peak
plasma concentration within 1 hour.
3) Ibuprofen is partially absorbed on oral administration.
4) Piroxicam is a non -steroidal anti -inflammatory drug which inhibits cyclooxygena se enzyme.
5) Ketorolac has moderate anti-inflammatory action and potent analgesic activity.

Fill in the Blanks

6) ________ is used to inhibit the clotting of blood and prevent strokes and heart attacks in individuals at high risk.
7) The drugs of _____________ are too toxic for repetitive use.
8) _____________ is well-absorbed on oral administration and is highly bound to plasma proteins (90-99%).
9) ___________ is a non -steroidal anti -inflammatory drug used for treating arthritis, menstrual cramps, pain, and colonic polyps.
10) _____________ is a new non -steroidal anti -inflammatory drug whose exact mechanism of action is unknown.

Answers

1) True 2) False 3) False 4) True 5) True 6) Aspirin 7) Pyrazolone derivative group 8) Ibuprofen 9) Celecoxib 10) Nefopam

Important Summary For one mark Question

1) Non-Steroidal Anti -Inflammatory Drugs (NSAIDs) are used to treat inflammation, mild-to-moderate pain, and fever.
2) Aspirin is used to inhibit the clotting of blood and prevent strokes and heart attacks in individuals at high risk.
3) The drugs of pyrazolone derivative group are too toxic for repetitive use.
4) Phenylbutazone is quickly and wholly absorbed from the GIT and reaches the peak plasma concentration within 2 hours.
5) Oxyphenbutazone (a metabolite and analogue of phenylbutazone) has the same range of activity, therapeutic uses, and toxicity as its parent compound.
6) Unlike other NSAIDs, indomethacin also inhibits phospholipase A2 enzyme, which catalyse the release of arachidonic acid from phospholipids.
7) Ibuprofen is a non -steroidal anti -inflammatory drug originally marketed as Brufen.
8) Ibuprofen is well-absorbed on oral administration and is highly bound to plasma proteins (90-99%).
9) Mefenamic acid is a non -steroidal anti -inflammatory drug which inhibits cyclooxygenase and exhibits anti -inflammatory, analgesic and antipyretic properties.
10) Diclofenac is an antipyretic, analgesic, and anti-inflammatory drug.
11) Piroxicam is a non -steroidal anti -inflammatory drug which inhibits cyclooxygenase enzyme.
12) Ketorolac has moderate anti-inflammatory action and potent analgesic activity .
13) Comparatively, nimesulide is a COX -2 selective non -steroidal anti – inflammatory drug having analgesic and antipyretic properties.
14) Celecoxib is a non -steroidal anti -inflammatory drug used for treating arthritis, menstrual cramps, pain, and colonic polyps.
15) The analgesic efficiency of paracetamol is same as aspirin, but its therapeutic doses have weak anti inflammatory effects.
16) Nefopam is a new non -steroidal anti -inflammatory drug whose exact mechanism of action is unknown.

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