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pharmacyPharmacy Exams

Bcs Classification


◆ BCS classification is differentiate the drugs on the basis of their solubility and permeability.

◆ Solubility classification is based on U.S.P. aperture.

Proposed by:- Amidon (in 1995)

◆ 4 classes of BCS Classification????

Class 1st:- High permeability ,High Solubility

●Eg.:-Paracetamol, Propranolol, Metoprolol , Theophylline, Chloroquine, Diltiazem.

Class 2nd:-High permeability, Low Solubility

●Eg.:-Phenytoin,Nifedipine, Carbamezapine, Danazol, Glibenclaimide, ketoconazole

● IVIVC is usually expected for class II drugs.

Class 3rd:-Low permeability, High Solubility

Eg.:-Cimetidine, Captopril,Atenolol, Ranitidine, Metformin, Acyclovir.

Class 4th:-Low Permeability ,Low Solubility

Eg.:-Chlorothiazide, Furosemide, Taxol, Cyclosporine-A, Ellagic acid, Ritonavir, Saquinavir.

● Drugs of class IV are problematic for effective oral administration

Significance of BCS

◆ Imp. for determine the bioavailability of drugs.

◆reduce cost & time
◆ Applicable in clinical drug development process.


Que 1:- A drug of low water solubility when orally is absorbed up to 90% of the administered dose.
The drug belongs to which class according to BCS classification?

 (A) Class IV
 (B) Class III
 (C) Class II
 (D) Class I.