1. QSAR method involves
a. Target structure
b. Target pr operties
c. Ligand x -ray s tructure
d. Ligand p roperties
2. One of the following is not used in QSAR:
a. Molecular connectivity index
b. Molecular s imilarity i ndex
c. Topological polar surface area
d. Partition coefficient
3. One of the following is a quantum chemical parameter:
a. STERIMOL
b. Taft c onstant
c. Highest occupied molecular orbital
d. Hammett’s c onstant
4. Which of the following is analogous to σ constant?
a. log P
b. R f
c. pK a
d. E s
5. Which of the following is analogous to π constant?
a. pK a
b. k’
c. E s
d. MW
6. Which of the following is a QSAR technique performed manually?
a. Hansch approach
b. Fujita Ban approach
c. Free Wilson approach
d. Topliss approach
7. In 3D QSAR, blue regions indicate favourable points for
a. Bulky groups
b. Smaller groups
c. Electron-rich groups
d. Electron-deficient groups
8. In 3D QSAR, green regions indicate favourable points for
a. Bulky groups
b. Smaller groups
c. Electron-rich groups
d. Electron-deficient groups
9. In 3D QSAR, red regions indicate favourable points for
a. Bulky groups
b. Smaller groups
c. Electron-rich groups
d. Electron-deficient groups
10. 10. In 3D QSAR, yellow regions indicate favourable points for
a. Bulky groups
b. Smaller groups
c. Electron-rich groups
d. Electron-defi cient groups
Answers Key
1. d
2. b
3. c
4. c
5. b
6. d
7. d
8. a
9. c
10. b
