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Disorders of Platelets, Bleeding Disorders and Basic Transfusion Medicine MCQs with Answers

1. If a patient is on parenteral heparin therapy, the following test is used to monitor the administration:
A. Whole blood coagulation time
B. Prothrombin time
C. Thrombin time
D. Activated partial thromboplastin time

2. Chronic ITP is characterised by the following features except:
A. Splenomegaly
B. Reduced platelet lifespan
C. Reduced number of megakaryocytes in the bone marrow
D. Demonstration of anti-platelet IgG antibody

3. For manifest bleeding haemophilia, the activity of factor VIII is generally:

  1. A. More than 75%
  2. B. 50-75%
  3. C. 25-50%
  4. D. Below 25%

4. Disseminated intravascular coagulation (DIC) is characterised by the following except:
A. Thrombocytopenia
B. Microangiopathic haemolytic anaemia
C. Presence of FDPs in the blood
D. Normal prothrombin time

5. Naturally -occurring antibodies in the serum of a non -transfused person are:

  1. A. IgA
  2. B. IgD
  3. C. IgG
  4. D. IgM

6. Tests for platelet function include all except :
A. Platelet adhesion tests
B. Ethanol gelation test
C. Aggregation test
D. Granular content of platelets

7. Heparin induced thrombocytopenia causes:

  1. A. Bleeding
  2. B. Thrombosis
  3. C. Both bleeding are thrombosis
  4. D. No symptoms

8. Antibodies in chronic ITP are:

  1. A. IgA
  2. B. IgM
  3. C. IgE
  4. D. IgG

9. Which of the following is not included in TTP triad?
A. Anti-platelet antibodies
B. Thrombocytopenia
C. Microangiopathic haemolytic anaemia
D. Fibrin microthrombi

10. Bernard -Soulier Syndrome is a defect in:

  1. A. Platelet aggregation
  2. B. Platelet adhesion
  3. C. Platelet release reaction
  4. D. Platelet morphology

11. Most common hereditary coagulation disorder is:

  1. A. Haemophilia A
  2. B. Haemophilia B
  3. C. von Willebrand’s disease
  4. D. Protein C deficiency

12. Most common manifestation of DIC is:
A. Bleeding
B. Thrombosis
C. Microangiopathic haemolytic anaemia
D. Organ damage

13. Bombay blood group is characterised by:
A. Absence of A gene
B. Absence of B gene
C. Absence of both A & B genes
D. Absence of H gene

14. Hemolytic disease of newborn occurs when:
A. Mother Rh+ve, foetus Rh –ve
B. Mother Rh-ve, foetus Rh +ve
C. Both mother and foetus Rh –ve
D. Both mother and foetus Rh +ve

Answers Key
1) = D, 2) = C, 3) = D, 4) = D, 5) = D, 6) = B, 7) = B, 8) = D, 9) = A, 10) = B, 11) = C, 12) = A, 13) = D, 14) = B