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Drugs acting on Autonomic Nervous System:- Hand written notes

Description

  • Drugs acting on Autonomic Nervous System
  • Adrenergic Neurotransmitters:
  • Biosynthesis and catabolism of catecholamine.
  • Adrenergic receptors (Alpha & Beta) and their distribution.
  • Sympathomimetic agents: SAR of Sympathomimetic agents
  • Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
  • Indirect acting agents:
  • Hydroxyamphetamine,
  • Pseudoephedrine,
  • Propylhexedrine.
  • Agents with mixed mechanism:
  • Ephedrine,
  • Metaraminol.
  • Adrenergic Antagonists:
  • Alpha adrenergic blockers: Tolazoline*,
  • Phentolamine,
  • Phenoxybenzamine, Prazosin,
  • Dihydroergotamine, Methysergide.
  • Beta adrenergic blockers: SAR of beta
  • blockers, Propranolol*,
  • Metibranolol, Atenolol, Betazolol,
  • Bisoprolol, Esmolol, Metoprolol,
  • Labetolol, Carvedilol.
  • Biosynthesis and catabolism of acetylcholine.
  • Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.
  • Parasympathomimetic agents: SAR of
  • Parasympathomimetic agents Direct acting agents:
  • Acetylcholine,
  • Carbachol*,
  • Bethanechol,
  • Methacholine,
  • Pilocarpine.
  • Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible):
  • Physostigmine, Neostigmine*,
  • Pyridostigmine, Edrophonium chloride,
  • Tacrine hydrochloride,
  • Ambenonium chloride,
  • Isofluorphate,
  • Echothiophate iodide,
  • Parathione, Malathion.
  • Cholinesterase reactivator: Pralidoxime chloride.
  • Cholinergic Blocking agents:
  • SAR of cholinolytic agents Solanaceous alkaloids and analogues:
  • Atropine sulphate, Hyoscyamine
    sulphate, Scopolamine hydrobromide, Homatropine hydrobromide,
    Ipratropium bromide*.
    Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate
    hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*,
    Glycopyrrolate, Methantheline bromide, Propantheline bromide,
    Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride,
    Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide,
  • Ethopropazine hydrochloride.
  • Subject:- Medicinal chemistry 1
  • Course:- B.pharm (pharmacy), D.pharm
  • Semester:- 4th sem , sem :- 4

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