Description
- Drugs acting on Autonomic Nervous System
- Adrenergic Neurotransmitters:
- Biosynthesis and catabolism of catecholamine.
- Adrenergic receptors (Alpha & Beta) and their distribution.
- Sympathomimetic agents: SAR of Sympathomimetic agents
- Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
- Indirect acting agents:
- Hydroxyamphetamine,
- Pseudoephedrine,
- Propylhexedrine.
- Agents with mixed mechanism:
- Ephedrine,
- Metaraminol.
- Adrenergic Antagonists:
- Alpha adrenergic blockers: Tolazoline*,
- Phentolamine,
- Phenoxybenzamine, Prazosin,
- Dihydroergotamine, Methysergide.
- Beta adrenergic blockers: SAR of beta
- blockers, Propranolol*,
- Metibranolol, Atenolol, Betazolol,
- Bisoprolol, Esmolol, Metoprolol,
- Labetolol, Carvedilol.
- Biosynthesis and catabolism of acetylcholine.
- Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.
- Parasympathomimetic agents: SAR of
- Parasympathomimetic agents Direct acting agents:
- Acetylcholine,
- Carbachol*,
- Bethanechol,
- Methacholine,
- Pilocarpine.
- Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible):
- Physostigmine, Neostigmine*,
- Pyridostigmine, Edrophonium chloride,
- Tacrine hydrochloride,
- Ambenonium chloride,
- Isofluorphate,
- Echothiophate iodide,
- Parathione, Malathion.
- Cholinesterase reactivator: Pralidoxime chloride.
- Cholinergic Blocking agents:
- SAR of cholinolytic agents Solanaceous alkaloids and analogues:
- Atropine sulphate, Hyoscyamine
sulphate, Scopolamine hydrobromide, Homatropine hydrobromide,
Ipratropium bromide*.
Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate
hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*,
Glycopyrrolate, Methantheline bromide, Propantheline bromide,
Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride,
Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, - Ethopropazine hydrochloride.
- Subject:- Medicinal chemistry 1
- Course:- B.pharm (pharmacy), D.pharm
- Semester:- 4th sem , sem :- 4
