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pharmacy Topic wise MCQs

General Pharmacology MCQs with Answers (Part:- 3)

1. All are inhibitors of cytochrome P-450 enzymes except :
a. Amiodarone
b. Disulfiram
c. Fluoxetine
d. Rifampicin

2. When causes least “gain in weight”?
a. Olanzapine
b. Risperidone
c. Quetiapine
d. Ziprasidone

3. Loading dose depends on the following factors except :
a. Drug concentration to be achieved
b. Volume of distribution
c. Clearance of the drug
d. Bioavailability of drug

4. How long does the protection from passive immunization using an immune globulin preparation typically last ?
a. 1 to 3days
b. 1 to 3 weeks
c. 1 to 3 months
d. 1 to 3 years

5. Half life does not help in estimating :
a. Margin of safety
b. Time taken to eliminate the drug completely from the body
c. Dosing schedule
d. Cone, of drug in body at a particular time after its administration

6. Therapeutic index of a drug is an indicator of :
a. Potency
b. Safety
c. Action
d. Efficacy

7. All are reasons for reducing drug dosage in elderly except :
a. They are lean and their body mass is less
b. Have decreasing renal function with age
c. Have increased baroreceptor sensitivity
d. Body water is decreased

8. The drugs that does not cause Raynaud’s phenomenon:
a. Vincristine
b. Bleomycin
c. Vinblastin
d. Cisplatin

9. Competitive inhibition :
a. Response depends on antagonist concentration
b. Antagonist binds to same receptor as agonist
c. Binds to different sites
d. Reduces intrinsic activity of agonist

10. Which one of the opioids has maximum plasma protein binding capacity ?
a. Morphine
b. Sulfentanil
c. Fentanyl
d. Pethidine

11. Which of the following given in pregnancy has teratogenic effects :
a. Vit. B6
b. Vit. B3
c. Folic acid
d. Vit. D

12. Clearance means :
a. Rate of elimination/plasma concentration
b. Plasma concentration/half life
c. Time taken for the plasma concentration of the drug to be reduced to half its original value
d. Rate of elimination X plasma concentration

13. Steady state means :
a. Dose rate X clearance
b. Dose rate/clearance
c. Clearance/dose rte
d. Rate of elimination/plasma concentration

14. Drugs which cannot be safely used in pregnancy all except ?
a. Tetracycline
b. Sulphonylurea
c. Heparin
d. Warfarin

15. The antibiotic which cannot be safely used in pregnancy are all except :
a. Tetracycline
b. Ampicillin
c. Streptomycin
d. Sulphonamides

16. Zero order kinetics is not followed by :
a. Phenytoin
b. Ethanol
c. Barbiturates
d. Salicylates

17. If a drug is given repeatedly at approximately the same time as its half life, after how many dosages will the drug achieve a steady a state in plasma :
a. 2 – 3
b. 4 – 5
c. 8 – 9
d. 6 – 8

18. To increase the fetal lung maturity the drug to be used is :
a. Methyldopa
b. Propranolol
c. Insulin
d. Betamethasone

19. True regarding “Plasma half life” of drugs :
a. Maximum effective dose of drug
b. Max. lethal effect
c. Potency of drug
d. Dose frequency interval

20. Downgrading of receptors is due to
a. Increased uptake of agonist by them
b. Increased interaction with antagonist
c. Both of the above
d. None of the above

21. Which of the following does not cross placenta ?
a. 131I
b. Heparin
c. Warfarin
d. Dicoumarol

22. All are examples of prolong except :
a. Enalapril
b. Cortisone
c. Azathioprine
d. Mercaptopurine

23. True about partial agonist is :
a. Produces maximal effect
b. Supramaximal effect
c. Produces submaximal effect
d. Effect in opposite direction

24. Basic drug binds to :
a. α-acidic glycoprotein
b. Albumin
c. Lipoprotein
d. Mucoprotein

25. Km value indicates :
a. Purity of enzyme
b. Physiological role
c. Half life enzyme drug complex
d. Affinity

26. Placebo effect is :
a. Pharmacological
b. Psychological
c. Trial of drug effect
d. Drug dependence

27. Generic drug true is :
a. High cost
b. Increased bioavailability
c. Low cost
d. Reduced clearance

28. Oxidative elimination of drug :
a. Conjugation
b. Azo reduction
c. Acetylation
d. Sulfoxide

29. Monitoring of plasma level is required in :
a. Carbamazepine
b. Diazepam
c. Valproic acid
d. Phenytoin

30. Which of the following drug has high first pass metabolism :
a. Propranolol
b. Phenytoin
c. Doxycycline
d. Pentazocine

31. All are examples of microsomal inducers except :
a. Phenytoin
b. Ethanol
c. Cimetidine
d. Rifampicin

32. All are examples of prodrug except :
a. Enalapril
b. Bacampicillin
c. Levodopa
d. Phenylbutazone

33. Following drugs are hepatic microsomal inducers except :
a. Alcohol
b. Cimetidine

c. Phenyramine
d. Sulphonamides

34. All drug can cross placenta except :
a. Heparin
b. Diazepam
c. Theophylline
d. Warfarin

35. Drug contraindicated with pregnancy :
a. Hydralazine
b. Propranolol
c. Methyldopa
d. Magnesium sulphate

36. The advantages of transdermal delivery system are a/e :
a. High peak plasma level
b. Slow releasing
c. Continuous
d. Effect comes late

37. Which drug causes hyperuricemia is :
a. Pyrazinamide
b. Rifampicin
c. Ethambutol
d. Streptomycin

38. Which is not prodrug :
a. Oxyphenbutazone
b. Azathioprine
c. Cholecaflciferol
d. Sulindac

39. Plasma monitoring is essential in therapy of :
a. Ethosuccimide
b. Phenobarbitone
c. Phenytoin
d. Sodium valproate

40. Which of the following avoids lst bypass effect of drug :
a. Intra-arterial injection
b. Rectal suppositories
c. Intravenous injection
d. Oral insertion

48. Which is the advantage of sublingual route of administration of drugs :
a. Prevents first pass effect
b. Easy to administer
c. Lipid soluble
d. Can be spitted out with signs of toxicity

49. Drugs mostly cross biological membranes by :
a. Passive diffusion
b. Active diffusion
c. Active transport
d. Carrier mediated transport
e. All of the above

50. The alkaline drug (Amidopyrine) is absorbed from:
a. Stomach
b. Proximal small intestine
c. Distal small intestine
d. Colon

51. All of the following are protein bound except :
a. Propranolol
b. Atenolol
c. Phenylbutazone
d. Warfarin

52. What is prodrug :
a. Drug which increase efficiency of another drug
b. Metabolic end product
c. Inactive drug which gets activated in the body
d. Drug which competes with another for metabolism

53. Prodrugs are :
a. Lisinopril
b. Ramipril
c. Enalapril
d. Captopril

54. Which cytochrome is responsible for drugs metabolism?
a. P-450
b. C-3b
c. C-3A
d. C-2a

55. Which of the following statements is correct ?
a. Most drugs are absorbed in ionised form
b. Basic drugs are generally bound to plasma albumin
c. Microsomal enzymes are located in the mitochondria of hepatic cells
d. Blood brain barrier is deficient at the chemoreceptor trigger zone

56. Enzyme cytochrome p450 inhibitors are :
a. Sodium valproate
b. INH
c. Rifampicin
d. Ethambutol

57. Drug with extensive first pass metabolism :
a. Propranolol
b. Digoxin
c. Quinidine
d. Chlorpromazine

58. Which of the following shows high first pass metabolism :
a. Propranolol
b. Phenobarbitone
c. Phenylbutazone
d. Phenytoin

59. Substrate concentration and velocity curve indicates :
a. Michelis – Mentons equation
b. Inverse relation
c. Zero order kinetics
d. All of the above

60. Plasma concentration of drug at time 0 is 96 g/ml. If tl/2 is 2 hoursconcentration in plasma at 10 hours will be :
a. 4
b. 24
c. 12
d. 3

Answers

  1. d. Rifampicin
  2. d. Ziprasidone
  3. c. Clearance of …
  4. c. 1 to 3 months
  5. a. Margin of …
  6. b. Safety
  7. c. Have increased …
  8. a and c
  9. b. Antagonist …
  10. d. Pethidine
  11. d. Vit. D
  12. a. Rate of …
  13. b. Dose rate/ …
  14. c. Heparin
  15. b. Ampicillin
  16. c. Barbiturates
  17. b. 4 – 5
  18. d. Betamethasone
  19. d. Dose …
  20. a. Increased …
  21. b. Heparin
  22. c. Azathioprine
  23. c. Produces …
  24. a. α-acidic …
  25. c. Half life …
  26. b. Psychological
  27. c. Low cost
  28. d. Sulfoxide
  29. d. Phenytoin
  30. a. Propranolol
  31. c. Cimetidine
  32. d. Phenylbutazone
  33. b. Cimetidine
  34. a. Heparin
  35. b. Propranolol
  36. a. High peak …
  37. a. Pyrazinamide
  38. a. Oxyphenbu ….
  39. c. Phenytoin
  40. a. Intra-arterial …
  41. c. Drug activated …
  42. None
  43. a. Metyrapone
  44. c. Chlorpromazine
  45. d. Margin of …
  46. b. M- Dopa
  47. b and c
  48. a. Prevents …
  49. a. Passive …
  50. b. Proximal …

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