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pharmacy Topic wise MCQs

General Pharmacology MCQs with Answers (Part:- 4)

61. T 1/2 of a drug can determine all the following except :
a. Dosing interval
b. Elimination time

c. Steady plasma concentration
d. Therapeutic dosage

62. Indiosyncrasy is :
a. A genetically determined abnormal reaction drugs
b. A characteristic toxic effect at therapeutic doses
c. An altered physiological state produced by repeated drugs use
d. An immunologic ally mediated reaction

63. Drug which crosses the placental barrier is :
a. Phenytoin
b. Diazepam
c. Corticosteroids
d. All of the above

64. The effects of hypoglycemia is marked by :
a. Warfarin
b. Beta blockers
c. Calcium channel blockers
d. Aminoglycosides

65. The intake of which of the following is associated with an increase in weight :
a. Chlorpromazine
b. Methyldopa
c. OCP
d. Thyroxine

66. Gout is precipitated by all except :
a. Furosemide
b. Vincristine
c. Penicillin
d. Sulfinpyrazone

67. Which of the following drugs causes post anaesthetic muscle stiffness :
a. Fentanyl
b. Pyridostigmine
c. Suxamethonium
d. Gallamine

68. Drugs absorbed by active transport is :
a. Propranolol
b. Ergotamine
c. Levodopa
d. Amantidine

69. Drug with extensive first pass metabolism :
a. Propranolol
b. Haloperidol
c. Diazepam
d. Acetazolamide

70. Cough is an adverse reaction with intake of :
a. Captopril
b. Prazosin
c. Nifedipine
d. Thiazide

71. Cough is an adverse reaction seen with intake of:
a. Thiazide
b. Nifedipine
c. Enalapril
d. Prazosin

72. Which of the following is not a dose related reaction :
a. Myocardial irritation of quinidine
b. Hypoglycemia of tolbutamide
c. Digitalis induced arrhythmia
d. Drug fever of sulpha

73. Which dose not cross placental barrier :
a. Diazepam
b. Pethidine
c. Atropine
d. Dicoumerol

74. Urine is coloured due to the intake of :
a. Phenindione
b. Phenobarbitone
c. Phenytoin
d. Quinine

75. Not a prodrug :
a. Lisinopril
b. Enalapril
c. Ramipril
d. Famotidine

76. Which drug has a high first pass effect :
a. Amiodarone
b. Phenytoin
c. Verapamil

d. Disopyramide

77. Urine is coloured due the intake of :
a. Phenindione
b. Phenobarbitone
c. Phenytoin
d. Quinine

78. Drugs which increase the metabolism of warfarin in/are :
a. Rifampicin
b. Septran
c. Phenylbutazone
d. Phenobarbitone

79. Which one of the following drugs dose not exhibit zero order kinetics :
a. Phenytoin
b. Ethanol
c. Salicylate
d. Ranitidine

80. All the prodrugs except :
a. Enalapril
b. Paracetamol
c. Sulphamethoxazole
d. Trimethoprim

81. One of the following in high doses can cause convulsions :
a. Penicillin
b. Sulphonamides
c. Aminoglycosides
d. Erythromycin

82. Canrenone is the prodrug of :
a. Ampicillin
b. Spironolactone
c. Frusemide
d. Acetazolamide

83. Which is used in drug induced ulcers :
a. Antacids
b. Ranitidine
c. Omeprazole
d. Misoprostol

84. The following is a prodrug :
a. Lovastatin
b. Pravostatin
c. Cetrivastatin
d. Fluvastatin

85. The following has maximum propensity for photodermatitis :
a. Oxytetracycline
b. Doxycycline
c. Minocycline
e. Beta 2 agonist

86. Chronic ulceration would most likely occur following administration of :
a. Carbenicillin
b. Clindamycin
c. Chloramphenicol
d. Colistin B

87. Which is an Ototoxic drug :
a. Tetracycline
b. Vincristine
c. Penicillin
d. Sulphonamide

88. Psychosis can be caused by :
a. Steroids
b. INH
c. Chloroquine
d. All of above

89. Drug which increases absorption of oral iron :
a. Folic acid
b. Nalidixic acid
c. Vitamin C
d. Tetracycline

90. In G-6 PD deficiency, hemolysis occurs most commonly with :
a. Sulphonamide
b. INH
c. Amphotericin B
d. Primaquine

91. Which of the following are the recognised causes of rapidly progressive glomerulonephritis :
a. Indomethacin
b. Penicillamine
c. Lead
d. Rifampicin

92. All of the following drug can cause photo-dermatitis except :
a. Griseofulvin
b. Chloroquine
c. Captopril
d. Oral contraceptive

93. All the following drugs cause hirsutism except :
a. Phenytoin
b. Minoxidil
c. Corticosteroids
d. Heparin

94. The following cause macrocytic anemia except :
a. Pyrimethamine
b. Methotrexate
c. Pentamidine
d. Trimethoprim

95. Hypersensitive cholestatic jaundice is caused by:
a. Chlorpromazine
b. Rifampicin
c. Halothane
d. Tetracycline

96. All cause hyperprolactinemia except :
a. Metoclopramide
b. Haloperidol
c. Trifluperazine
d. Lasix

97. Hirsutism is caused by :
a. Minoxidil
b. Phenytoin
c. Hydralazine
d. All

98. Drug induced hypothermia is caused by all the drugs, except :
a. Phenothiazines
b. Barbiturates
c. MAO-inhibitors
d. Ethanol

99. Drug implicated in the causation of pancreatitis :
a. L- Asparaginase
b. Cyclophosphamide
c. Cyclosporine
d. Methotrexate

100. Galactorrhea is caused by all except :
a. Metoclopramide
b. Digitalis
c. Reserpine
d. Methyldopa

101. Cholestatic jaundice occurs with intake of all except :
a. Erythromycin
b. INH
c. O.C. pills
d. Nifedipine

102. All of the following are hepatotoxic except :
a. Erythromycin
b. Tetracycline
c. Choloroquine
d. Rifampicin

103. The following drug is used for osteoporosis :
a. Ranitidine
b. Raloxifene
c. Ramipril
d. Riclopride

104. Fanconi’s syndrome is caused by :
a. Cephalosporins

b. Chloramphenicol
c. Deceased pseudocholinesterase
d. Old and degraded tetracyclines

105. Agranulocytosis is common with :
a. Chloramphenicol
b. Methotrexate
c. Sulpha drugs
d. Amikacin

106. Gynecomastia is caused by :
a. Phenytoin
b. Cushing’s syndrome
c. Conn’s syndrome
d. None

107. Drug which is not a cause of a chronic active hepatitis :
a. INH
b. Methyldopa
c. Chlorpromazine
d. Oxyphenacetin

108. Not an ototoxic drug :
a. Neosporine
b. Amikacin
c. Vincristine
d. Aminoglycoside

109. Non ischaemic chest pain is caused by :
a. Bleomycin
b. Vincristine
c. Cyclophosphamide
d. Cisplatinum

110. Leukoencephalopathy is seen with use :
a. Vincristine
b. Cyclophosphamide
c. Methotrexate
d. 5-FU

Answers

  • 61. d. Therapeutic …
  • 62. a. A genetically …
  • 63. d. All of the above
  • 64. b. Beta blockers
  • 65. c. OCP
  • 66. d. Sulfinpyrazone
  • 67. c. Suxamethonium
  • 68. c. Levodopa
  • 69. a. Propranolol
  • 70. a. Captopril
  • 71. c. Enalapril
  • 72. d. Drug fever …
  • 73. c. Atropine
  • 74. a. Phenindione
  • 75. a. Lisinopril
  • 76. c. Verapamil
  • 77. a. Phenindione
  • 78. a and d
  • 79. d. Ranitidine
  • 80. b, c and d
  • 81. a. Penicillin
  • 82. b. Spironolactone
  • 83. c. Omeprazole
  • 84. a. Lovastatin
  • 85. b. Doxycycline
  • 86. b. Clindamycin
  • 87. b. Vincristine
  • 88. d. All of above
  • 89. c. Vitamin C
  • 90. a. Sulphonamide
  • 91. d. Rifampicin
  • 92. d. Oral contrace …
  • 93. d. Heparin
  • 94. c. Pentamidine
  • 95. a and b
  • 96. d. Lasix
  • 97. a and b
  • 98. c. MAO-inhibitors
  • 99. a. L- Asparaginase
  • 100. b. Digitalis
  • 101. b. INH
  • 102. c. Choloroquine
  • 103. b. Raloxifene
  • 104. d. Old and …
  • 105. a and d
  • 106. a. Phenytoin
  • 107. c. Chlorpromazine
  • 108. a. Neosporine
  • 109. a. Bleomycin
  • 110. c. Methotrexate

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