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Macrolides:- PPT / PDF

Description

Macrolides
Erythromycin
Clarithromycin
Azithromycin
Mechanism of action
Inhibit protein synthesis by binding to the 50’s subunit
Antibacterial activity
Bactericidal or bacteriostatic, depending on the concentration and type of bacteria
Chapter:- Chemotherapy
Pharmacology:- 3
Pharmacokinetics
Erythromycin base
Azithromycin
Pharmacokinetics
Antibacterial spectrum
Erythromycin – Mainly effective on G+ bacteria
A. Gram- positive bacteria
Staph. Aureus
S. pneumoniae
URTIs (eg. Otitis media, pharyngitis)
LRTIs (eg. Pneumoniae)
S. pyogens , C. diphtheria
B. Gram- negative bacteria
T. pallidum
C. Intracellular organisms
L. pneumophila, M. pneumoniae, C. trachomatis
• Indications for erythromycin
• Clarithromycin
Antibacterial spectrum
• Azithromycin
• Antibacterial spectrum
A. Gram- positive bacteria
Staph. Aureus, S. Pneumoniae, S. Pyogens
B. Gram- negative bacteria (> erythromycin)
M. catarrhalis, H. influenzae
C. Intracellular organisms (> erythromycin)
L. Pneumophila, M. pneumoniae, Chlamydia species
• Macrolides: Therapeutic Uses
• Macrolides’ Dispensing Issues
• Side effects of macrolides
• Macrolides: Side Effects

  • Subject:- pharmacology 3
  • Course:- B.pharm (pharmacy),
  • Semester:- 6th sem , sem :- 6

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