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Medicinal chemistry 2:- Hand Written Notes

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Q.1 (a) Define and classify oral hypoglycemic agents. 06
(b) Explain the SAR of local anesthetic agents. 05
(c) Give detail note on thyroid hormones and write a note on anti-thyroid drugs. 05
Q.2 (a) Write a note on nomenclature and stereochemistry of steroids. 06
(b) Discuss coagulants and anticoagulants. 05
(c) Give detail note on oral contraceptives. 05
Q.3 (a) Define and classify Antiarrhythmic drugs. Explain mode of action in each class. 06
(b) Write a note on proton pump inhibitors. 05
(c) Write a note on drugs used in congestive heart failure. 05
Q.4 (a) Give structure and uses of (i) Diltiazem (ii) Verapamil (iii) Clofibrate 06
(b) Explain types of diabetes and write a note on various insulin preparations. 05
(c) Write a short note on ACE inhibitors. 05
Q.5 (a) What are anti-histaminic? How they act? Classify them with examples. 06
(b) Write a note on HMG Co-A reductase inhibitors. 05
(c) Write a note on H2-antagonists. 05
Q. 6 (a) Define and Classify Antihypertensive agents with examples. 06
(b) Give Synthesis of (i) Diphenhydramine hydrochloride (ii) Furosemide 05
(c) Write a note on potassium sparing diuretics and thiazide diuretics. 05
Q.7 (a) Write detail classification and short mechanism of action of anticancer agents 06
(b) Give Synthesis of (i) Cimetidine (ii) Tolbutamide 05
(c) Write short note on corticosteroids.

Q.1 (a) Enlist various histamine receptors. Discuss neurochemistry of histamine. 06
(b) Give the synthesis of Promethazine hydrochloride and diphenhydramine
hydrochloride.
05
(c) Write a note on Nitroglycerin as a Vasodilator. 05
Q.2 (a) Classify Diuretics with one structure in each class. Write mechanism of action,
uses and side effect of Acetazolamide.
06
(b) Write informative note on Anti-hypertensive agents and give the synthesis of
Methyldopate hydrochloride.
05
(c) Write a note on Gastric Proton pump inhibitors. 05
Q.3 (a) Classify Antiarrhythmic agents with one structure in each class. Write synthesis
of Disopyramide phosphate.
06
(b) Write short notes on heparin as anticoagulant and give the synthesis of
Warfarin.
05
(c) Give the synthesis the following: (Any two)
(i) Isosorbide dinitrite (ii) Chlorthiazide (iii) Furosemide.
05
Q.4 (a) Explain in detail the nomenclature and stereochemistry of steroidal compounds. 06
(b) Write a note on Anti-hyperlipidemic agents. 05
(c) Write informative note on Sex hormones. 05
Q.5 (a) Give the synthesis and uses of the following: (Any two)
(i) Tobutamide (ii) Benzocaine (iii) Dibucaine.
06
(b) Write a note on Antithyroid agents. 05
(c) Write a note on the natural products used as antineoplastic agents. 05
Q. 6 (a) Define and classify Antidiabetic agents. Give the synthesis of Procaine. 06
(b) Classify anti neoplastic alkylating agents with relevant examples. 05
(c) Write a note on Oral contraceptives. 05
Q.7 (a) Discuss the SAR of Local anesthetics. 06
(b) Write a note on Drugs used in Congestive Heart Failure. 05
(c) Write a brief note on H2-antagonists.

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Subject:
Medicinal chemistry 2
Semester:
5
Cource:
Pharmacy

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