Medicinal chemistry 2 MCQs with Answers For GPAT and University examination
1. Propanol is
A. Muscarnic M1 receptor agonist
B. Non selective β- receptor antagonist
C. Selective β1agonist
D. Non selective dopaminergic antagonist
2. An acrylolyl moiety containing diuretic is
A. Indacrinone
B. Ethacrynic acid
C. Torsemide
D. Canrenone
3. The substitution of an aryl group which increase the electron density of carbonyl oxygen, in the structure of LA results in
A. Increased relative toxicity
B. Decreased relative toxicity
C. Increased local anaesthetics activity
D. Decreased local anaesthetic activity
4. Drug receptor site for Sulfonylurea is
A. muscarinic receptor
B. calcium channel
C. potassium channel
D. beta adrenergic receptor
5. Captopril, Lisinopril and Enalapril are
A. ACE inhibitors
B. Beta blockers
C. Alpha2 antagonists
D. None of the above
6. Chemically, mechlorethamine is
A. Bis(2-chloroethyl)(methyl)amine
B. Bis(2-chloromethyl)(ethyl)amine
C. Bis(2-chloroethyl)(propyl)amine
D. Bis(2-chloropropyl)(methyl)amine
7. Which one of the following local anesthetics belongs to the ester group?
A. Procaine
B. Bupivacaine
C. Lignocaine
D. Mepivacaine
8. The cisplatin can be used as
A. Calcium channel blocker
B. Antiarrhythemic drug
C. Antineoplastic cytotoxicity drug
D. Immuosuppressive agent
9. Which one of the following is essential for optimum activity of calcium channel blockers?
A. Phenyl substitution at 3rd position
B. Phenyl substitution at 4th position
C. Phenyl substitution at 5th position
D. Phenyl substitution at 6th position
10. Therapeutic use of amyl nitrite is
A. Treatment of angina pectoris
B. Treatment of methemoglobinemia
C. Treatment of syncope
D. None of the above
11. Steroid can used to
A. Stimulate muscle growth
B. Cause eye site
C. To increase intelligent
D. All of the above
12. The basic PPI pharmacophore is
A. 2-pyridyl methyl sulfinyl benzimidazole
B. 2-pyridyl ethyl sulfinyl benzimidazole
C. 1-pyridyl methyl sulfinyl benzimidazole
D. 1-pyridyl ethyl sulfinyl benzimidazole
13. The drug Promethazine is mainly used for treatment of?
A. Nausea
B. Motion sickness
C. Tension
D. All of the above
14. The term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours is
A. Carcinogenesis
B. Apoptosis
C. Metastasis
D. Mutagenesis
15. Busulfan acts by…
A. Fragmentation of DNA
B. Mispairing of nucleotides
C. Separation of DNA strands
D. All of the above
16. Activity of 6-Mercaptopurine can be increased by
A. Hydrophilic substitution at 6th position
B. Increase in the alkyl chain length
C. Any substitution at 2nd position
D. Decrease in the alkyl chain length
17. The starting material for synthesis of Nitroglycerine is
A. Trinitroglyceraldehyde
B. Glyceraldehyde
C. Trinitroglycerol
D. Glycerol
18. 4-[bis(2-Chloroethyl)amino]-L-phenylalanine is
A. Chlorambucil
B. Cyclophosphamide
C. Melphalan
D. Busulfan
19. The carbon-carbon double bond in steroids is indicated by—-
A. α
B. β
C. ∆
D. =
20. High blood pressure is the main cause of which of the following ?
A. Stroke
B. Cancer
C. Diabetes
D. Congestive heart failure
21. ………..determines the duration of action of sulphonylureas
A. Aliphatic group
B. Alkyl group
C. Amino group
D. Phenyl group
22. The following antiarrhythmic drug has the most prominent anticholinergic action
A. Disopyramide
B. Procainamide
C. Quinidine
D. Lignocaine
23. Methimazole is a
A. Antidiabetic drug
B. Antithyroid drug
C. Antianginal drug
D. None of the above
24. Famotidine acts as….
A. H1-receptor antagonist
B. Proton pump inhibitor
C. H1-receptor agonist
D. H2-receptor antagonist
25. Which of the following antianginal agents is a calcium channel blocker?
A. Nitroglycerin
B. Nifedipine
C. Isosorbide dinitrate
D. Nicorandil
26. Diuretic is
A. A Drug that accelerate the rate of urine formation
B. A Drug that accelerates heart rate
C. A drug that accelerates breathing rate
D. A drug that reduces heart rate
27. In PPI, Substitution of 4-methoxy group on pyridine results in
A. Increased activity
B. Decreased activity
C. Increased stability
D. Decreased stability
28. Which of the following is notused in the treatment of hyperthyroidism?
A. anti-thyroid drugs
B. synthetic thyroid hormone
C. beta blockers
D. none of the above
29. The starting material for synthesis of dibucaine is….
A. Indole
B. 2-formyl benzoic acid
C. 4-chloro acetophenone
D. Isatin
30. The active form of mercaptopurine is
A. 6-Thioguanophosphate
B. 6-Thioinosinic acid
C. 5-FDUMP
D. 5-FUMP.
31. Testosterone is secreted by ________
A. Sertoli cells
B. Leydig cells
C. Thyroid
D. Spermatogenic cells
32. Which of these diseases is not related to thyroid glands?
A. Cretinism
B. Myxoedema
C. Goitre
D. Acromegaly
33. Chemically meprylcaine belongs to the class______
A. Benzoic acid derivatives
B. Anilide derivatives
C. Amino benzoic acid derivatives
D. Miscellaneous agents
34. What is the function of LH hormone?
A. Stimulates oxidative respiration
B. Stimulates muscle growth
C. Causes color change in skin
D. Stimulates production of testosterone
35. How T3 differs from T4?
A. it is more acidly bound to plasma proteins
B. it has a shorter plasma half life
C. it is less potent
D. it has a longer latency of action
36. Repaglinide belongs to class….
A. Biguanides
B. Glitazones
C. Meglitinides
D. Glucosidase inhibitors
37. Which of the following Oral hypoglycemic drug belongs to Biguanide category ?
A. Tolbutamide
B. Acarbose
C. Metformin
D. Troglitazone
38. Which of the following diuretics should be used for hypercalcemia patients?
A. Osmotic diuretics
B. Loop diuretics
C. Carbonic anhydrous inhibitor diuretics
D. Potassium-sparing diuretics
39. The antihistamine with diphenyl methyl group is_______________.
A. Methdilazine
B. Phenindamine
C. Cyclizine hydrochloride
D. Pheniramine
40. Heterocyclic ring present in furosemide is
A. Pyridine
B. Furan
C. Pyrimidine
D. Pyridine
41. Steroids can——-
A. stimulate muscle growth
B. cause eyesight to improve
C. increase intelligence
D. decrease intelligence
42. Felodipine belongs to class…
A. 1,4-dihydropyridines
B. Calcium channel blockers
C. Antianginal agents
D. All of the above
43. Acetazolamide is—-
A. Carbonic anhydrase inhibitor
B. Loop Diuretic
C. Thiazide Diuretic
D. Potassium Sparing Diuretic
44. Choose the correct statement concerning statin drugs
A. Statins inhibit HMG Co-A reductase
B. Statins increse high affinity LDL receptors
C. Both A & B
D. None of the above
45. The receptor target for nitrates is
A. Cytostolic guanyl cyclase
B. Topoisomerase II
C. Cytostolic adenine cyclase
D. None of these
46. The primary site of action of thiazide diuretics is:
A. Proximal Distal tubule
B. Cortical diluting segmen
C. Ascending limb of loop of Henle
D. Collecting ducts
47. A primary source of histamine released during inflammatory conditions are:
A. Mast cells
B. B cells
C. Enterochromaffin-like cells
D. Presynaptic nerve terminals
48. In PPI, Substitution of electron accepting group on benzimidazole ring results in….
A. Increased activity
B. Reduced activity
C. Increased toxicity
D. Reduced toxicity
49. Which of the following drugs is an Antihistaminic class?
A. Promethazin
B. Pilocarpine
C. Prednisolone
D. Cycloserine
50. Which of the following histamine receptor increases the release of gastric acid?
A. H1 receptor
B. H2 receptor
C. H3 receptor
D. H4 receptor
51. Local anesthetic binds directly to____________.
A. Intracellular voltage dependent potassium channels
B. Intracellular voltage dependent sodium channels
C. Intracellular voltage dependent calcium channels
D. None of these.
52. Which of the following is NOT a good drug target for cardiac arrhythmias?
A. Calcium channel blockers
B. Potassium channel activators
C. Sodium channel blockers
D. Beta blockers
53. The type of ring which should be maintained for affinity at H2 receptor site in cimetidine ring is?
A. Cyclohexane
B. Piperazine
C. Imidazole
D. Pyrole
54. Which one of the following maintains pharmacokinetic profile of calcium channel blockers
A. Ester group at C3
B. Ester group at C5
C. C5 methyl group
D. All of the above.
55. Side effects of drug Omeprazole is —
A. Seizures
B. Low magnesium blood level
C. Lupus
D. All of the above
56. Which of the following drug is containing 1,3,4 thiadiazole ring?
A. Amiloride
B. Acetazolamide
C. Dichloropenamide
D. None
57. The starting material used for the synthesis of histamine is….
A. D-histidine
B. L-histidine
C. S-histidine
D. None of these.
58. The adrenal cortex produces ______
A. Adrenaline
B. Calcitonin
C. Epinephrine
D. Aldosterone
59. An example of drug from class piperazine antihistamine drug?
A. Cimetidine
B. Buclizine
C. Glycopyrrolate
D. All of the above
60. Which one of the following drug belongs to class nitrosoureas
A. Thiotepa
B. Lomustine
C. Busulfan.
D. Decarbazine.
