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Medicinal Chemistry II (BP501TT) IMP QUESTIONS B-PHARMACY 5th SEMESTER

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Medicinal Chemistry II (BP501TT)
IMP QUESTIONS
B-PHARMACY 5th SEMESTER
1). Discuss in detail about proton pump inhibitors along with its mechanism of action.
2). Short note on H2 receptor antagonist.
3). What is Diabetes? Classify antidiabetics with examples and give their mechanism
of action.
4). Enlist various histamine receptors. Discuss neurochemistry of histamine.
5). Define antihypertensive agents with its classification and write a note on calcium
channel blockers.
6). Discuss the SAR of Local anesthetics. (benzoic acid and aniline derivatives)
7). Write a short note on oral contraceptives. OR Give detail account on various
corticosteroids.
8). Explain in detail the nomenclature and stereochemistry of steroidal compounds.
9). Classify Diuretics with one structure in each class. Write mechanism of action,
uses and side effect of Acetazolamide.
10). Discuss coagulants and anticoagulants.
11). Define alkylating agents. Classify anti neoplastic alkylating agents with relevant
examples and mechanism of action.
12). Write a note on potassium sparing diuretics and thiazide diuretics / loop diuretics..
13). Give structure, IUPAC name uses and synthesis of
A. Methotrexate
B. Chlorthiazide
C. Furosemide
D. Dibucaine.
E. Cimetidine
F. Nitroglycerin
G. Methyldopa
H. Tolbutamide
I. Benzocaine

14). What are anti-histaminic? Classify H1-antagonist in detail. How they act ?
15). Write a note on HMG Co-A reductase inhibitors. OR Write a short note on ACE
inhibitors.
16). Classify anti-arrhythmic agents. Give synthesis of disopyramide phosphate.
17). Give detail note on thyroid hormones and write a note on anti-thyroid drugs.
18). Write a note on drugs used in congestive heart failure.
19). Write informative note on Sex hormones.
20). Give the synthesis of Promethazine hydrochloride and diphenhydramine
hydrochloride.

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