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pharmacyTopic wise MCQs

Neoplasia MCQs with Answers

1. Hamartoma refers to:
A. Tumour differentiating towards more than one cell line
B. Tumour arising from totipotent cells
C. Mass of disorganised but mature cells indigenous to the part
D. Mass of ectopic rests of normal tissue

2. Increased number of normal mitoses may be present in the following tissues except:

  1. A. Bone marrow cells
  2. B. Nails
  3. C. Hepatocytes
  4. D. Intestinal epithelium

3. A tumour is termed medullary when it is almost entirely composed of:

  1. A. Amyloid stroma
  2. B. Large areas of necrosis
  3. C. Abundant lymphoid tissue
  4. D. Parenchymal cells

4. All the following malignant tumours metastasise except:

  1. A. Synovial sarcoma
  2. B. Malignant mesothelioma
  3. C. Glioma
  4. D. Neuroblastoma

5. The following malignant tumours frequently spread through
haematogenous route except:

  1. A. Bronchogenic carcinoma
  2. B. Renal cell carcinoma
  3. C. Follicular carcinoma thyroid
  4. D. Seminoma testis

6. Degradation of ECM is brought about by the following except:

  1. A. Proteases
  2. B. Metalloproteinases
  3. C. Free radicals
  4. D. Cathepsin D

7. Grading of tumours depends upon the following except:

  1. A. Degree of anaplasia
  2. B. Metastatic spread
  3. C. Rate of growth of cells
  4. D. Degree of differentiation

8. Patients of xeroderma pigmentosum are prone to develop the following cancers except:

  1. A. Basal cell carcinoma
  2. B. Sweat gland carcinoma
  3. C. Malignant melanoma
  4. D. Squamous cell carcinoma

9. The primary target of reactive electrophiles is as under:

  1. A. Cytochrome P-450
  2. B. RNA
  3. C. DNA
  4. D. Mitochondria

10. Carcinogenic influence of radiation appears after:

  1. A. < 2 years
  2. B. 2-5 years
  3. C. 5-10 years
  4. D. > 10 years

11. The following hereditary diseases have higher incidence of cancers due to inherited defect in DNA repair mechanism except:

  1. A. Ataxia telangiectasia
  2. B. Xeroderma pigmentosum
  3. C. Familial polyposis coli
  4. D. Bloom’s syndrome

12. The following form of ionising radiation exposure is associated
with highest risk of cancer:

  1. A. a-rays
  2. B. b-rays
  3. C. g-rays
  4. D. X-rays

13. Women receiving oestrogen therapy have an increased risk of
developing the following cancers except:

  1. A. Breast cancer
  2. B. Endometrial carcinoma
  3. C. Gallbladder cancer
  4. D. Hepatocellular carcinoma

14. Important cyclins in cell cycle include the following except:

  1. A. Cyclin A
  2. B. Cyclin B
  3. C. Cyclin C
  4. D. Cyclin D

15. Bittner milk factor is a transmissible agent belonging to the following category:

  1. A. Acute transforming virus
  2. B. Slow transforming virus
  3. C. HTLV-I
  4. D. HTLV-II

16. Important examples of tumour suppressor genes implicated in human cancers include the following except:

  1. A. RB gene
  2. B. TP53
  3. C. APC
  4. D. ERB-B

17. An example of tumour-associated antigen (TAA) is:
A. Testis specific antigen (MAGE)
B. Alpha-fetoprotein (AFP)
C. Carcinoembryonic antigen (CEA)
D. Prostate specific antigen (PSA)

18. Hypercalcaemia as a paraneoplastic syndrome is observed in the following tumours except:
A. Squamous cell carcinoma lung
B. Small cell carcinoma lung
C. Renal cell carcinoma
D. Breast cancer

19. Lymphocytic infiltrate is frequently present in the following tumours indicative of host immune response except:
A. Seminoma testis
B. Medullary carcinoma breast
C. Papillary carcinoma thyroid
D. Malignant melanoma

20. The following antibody-stain is used in immunohistochemistry to identify epithelial cells:

  1. A. Desmin
  2. B. Vimentin
  3. C. Cytokeratin
  4. D. Neurofilaments

21. Which of the following viral infection is not known to produce any human tumour?

  1. A. Polyoma virus
  2. B. EBV
  3. C. HSV
  4. D. HTLV

22. All are autosomal dominant inherited cancer syndromes except:

  1. A. Retinoblastoma
  2. B. Xeroderma pigmentosum
  3. C. HNPCC
  4. D. Neurofibromatosis

23. Phosphorylation of retinoblastoma gene:
A. Inhibits cell replication
B. Promotes cellular quiescence
C. Stops cell cycle progression
D. Promotes cell division

24. p53:

  1. A. Activates cyclins
  2. B. Activates BAX
  3. C. Activates CDKs
  4. D. Activates bcl2

25. All are matrix metalloproteinases except:

  1. A. Collagenase
  2. B. Gelatinase
  3. C. Stromelysin
  4. D. Elastase

26. All are anti-angiogenesis factors except:
A. Thrombospondin-1
B. Basic fibroblast growth factor (bFGF)
C. Endostatin
D. Angiostatin

27. Which of the following is a test for mutagenicity?

  1. A. Kveim’s test
  2. B. Ame’s test
  3. C. Schilling’s test
  4. D. Mantoux test

28. All are autosomal dominant inherited cancer syndromes except:

  1. A. Retinoblastoma
  2. B. Xeroderma pigmentosum
  3. C. HNPCC
  4. D. Neurofibromatosis

29. DNA extraction is a pre-requisite for the following molecular techniques except:

  1. A. PCR technique
  2. B. In situ hybridisation
  3. C. Western blot technique
  4. D. Southern blot technique

30. All are methods of cell proliferation analysis except:

  1. A. Microspectrophotometry
  2. B. Flow cytometry
  3. C. PCR
  4. D. Immunohistochemistry

Answers Key
1) = C 2) = B 3) = D 4) = C 5) = D 6) = C 7) = B 8) = B 9) = C 10) = D 11) = C 12) = A 13) = C 14) = C 15) = B 16) = D 17) = D 18) = B 19) = C 20 = C 21) = A 22) = B 23) = D 24) = B 25) = D 26) = B 27) = B 28) = B 29) = B 30) = C

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