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pharmacyTopic wise MCQs

Genetic and Paediatric Diseases MCQs with Answers

by Ronakpatel0527

1. Teratogens are defined as agents which induce:

  1. A. Mitosis
  2. B. Carcinogenesis
  3. C. Birth defects
  4. D. Fallot’s tetralogy

2. For chromosomal study, it is best to use the following nucleated cells:

  1. A. Polymorphs
  2. B. Lymphocytes
  3. C. Epithelial cells
  4. D. Fibroblasts

3. For chromosomal study, the dividing cells are arrested by colchicine in the following phase of cell cycle:

  1. A. Prophase
  2. B. Metaphase
  3. C. Anaphase
  4. D. Telophase

4. Denver classification divides chromosomes based on their length into the following groups:

  1. A. A to C (3 groups)
  2. B. A to E (5 groups)
  3. C. A to G (7 groups)
  4. D. A to I (9 groups)

5. Polyploidy is generally not a feature of dividing cells of the following type:

  1. A. Megakaryocytes
  2. B. Hepatocytes
  3. C. Tubular cells
  4. D. Conceptus of abortions

6. Numeric abnormality in chromosome occurs in the following conditions except:

  1. A. Ph chromosome in CML
  2. B. Turner’s syndrome
  3. C. Klinefelter’s syndrome
  4. D. Down’s syndrome

7. Mutations affecting germ cells produce:

  1. A. Cancers
  2. B. Inherited diseases
  3. C. Congenital malformations
  4. D. Aneuploidy

8. In lysosomal storage diseases, the following cells are particularly involved:

  1. A. Hepatocytes
  2. B. Skeletal muscle
  3. C. Macrophages
  4. D. White pulp of spleen

9. Out of the following glycogenosis, the following is example of lysosomal storage disease:

  1. A. von Gierke’s disease
  2. B. Pompe’s disease
  3. C. Forbe’s disease
  4. D. Anderson’s disease

10. Blastomas are childhood tumours seen more often in the age range of:

  1. A. <4 years
  2. B. 5-9 years
  3. C. 10-14 years
  4. D. 14-16 years

11. All of the following are X-linked recessive disorders except:
A. Haemophilia A and B
B. Chronic granulomatous disease
C. G-6 PD deficiency
D. Sickle cell anaemia

12. Gaucher cells are positive for all except:

  1. A. PAS
  2. B. Mucicarmine
  3. C. Oil red O
  4. D. Prussian blue

Answers Key
1) = C, 2) = B, 3) = B, 4) = C, 5) = C, 6) = A, 7) = B, 8) = C, 9) = B, 10) = A, 11) = D, 12) = B