Biopharmaceutics & Pharmacokinetics (BP604TT)
Chapter 7 Nonlinear Pharmacokinetics
1. Non-linear pharmacokinetics is also known as………
(a) dose dependent
(b) enzyme capacity limited
(c) saturation pharmacokinetics
(d) All of the above
Answer: d
2. The characteristic of non-linear pharmacokinetics include…………..
(a) Area under the curve is proportional to the dose
(b) Elimination half-life remains constant
(c) Area under the curve is not proportional to the dose
(d) Amount of drug excreted through remains constant
Answer: c
3. Which of following drug shows non-linearity in hepatic excretion?
- (a) Carbamazepine
- (b) Propranolol
- (c) Penicillin
- (d) Thiopental
Answer: a
4. Pharmacokinetics parameters change as per………… of dose administered?
a) Size
b) Route
c) Both of free above
d) None of the above
Answer: a
5. Linear Pharmacokinetics is………………
a) Dose dependent
b) Dose independent
c) Both of the above
d) None of the above
Answer: a
6. Non-linear Pharmacokinetics also called as…………
a) Mixed order
b) Saturated kinetics
c) Capacity Limited
d) All of the above
Answer: d
7. In…………..Pharmacokinetic parameters for a drug can change with change in dose.
a) Linear Pharmacokinetics
b) Non-linear Pharmacokinetics
c) Both of the above
d) None of the above
Answer: b
8. The………………….. is common cause of both dose and time dependent kinetics
a) Capacity limited Process
b) Dose volume
c) Enzyme induction
d) None of the above
Answer: c
9. When Km << C. In this condition…………..
a) Km – C = C
b) Km + C = C
c) Km + C = Km
d) Km – C = Km
Answer: b
10. Active processes which are Saturable in renal excretion of drug includes…….
a) Active tubular secretion
b) Active tubular reabsorption
c) Both of the above
d) None of the above
Answer: c
11. Linear Pharmacokinetics also referred as………….
a) First-order kinetics
b) Second order kinetics
c) Pseudo order kinetics
d) None of the above in
Answer: a
12. If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists.
a) Linearity
b) Non-linearity
c) Both of the above
d) None of the above
Answer: a
13. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.
a) Accumulation Index
b) Apparent volume of drug distribution
c) Accumulation factor
d) None of the above
Answer: a
14. Which of the following is correct statement about Nonlinear pharmacokinetics?
a. The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered
b. The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line.
c. the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
d. None of the above
Answer: c
15. Which of the following Factors causing Non-linearity?
a. Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination.
b. Nonlinearity may arise due to Capacity-limited metabolism.
c. Nonlinearity may arise due to alteration in protein binding characteristics
d. All of the above
Answer: d
16. In Michaelis-Menton Equation, When the value of Km = C
a. rate of process is half (1 /2) the maximum rate.
b. the elimination of most drugs follows first order kinetic
c. the elimination of most drugs follows zero order kinetic
d. the elimination of most drugs follows second order kinetic
Answer: a
17. Name the different methods used to estimate Km and Vmax graphically.
a. Direct Linear plot
b. Lineweaver —Burke plot or Klotz Plot
c. Graphical Method
d. All of the above
Answer: d
18. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.
a) True
b) False
Answer: a
19. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
a) When absorption is solubility or dissolution rate-limited
b) When absorption involves carrier-mediated transport systems
c) When a presystemic gut wall or hepatic metabolism attains saturation
d) Saturation of binding sites on plasma proteins
Answer: d
20. Which one of these is correct Michaelis-Menten equation?
a) –dC/dt = Vmax C/Km+C
b) dC/dt = Vmax C/Km+C
c) –dC/dt = Vmax C/Km
d) –dC/dt = Km+C / Vmax C
Answer: a
