Pharmacology II (BP602TP)
Respiratory Drugs
1. The following expectorant acts both directly on the airway mucosa as well as reflexly:
A.Potassium iodide
B.Guaiphenesin
C.Terpin hydrate
D.Bromhexine
2. Bromhexine acts by:
A.Inhibiting cough centre
B.Irritating gastric mucosa and reflexly increasing bronchial secretion
C.Depolymerizing mucopolysaccharides present in sputum.
D.Desensitizing stretch receptors in the lungs
3. Codeine is used clinically as:
A.Analgesic
B.Antitussive
C.Antidiarrhoeal
D.All of the above
4. Mucokinetic is a drug which:
A.Reduces airway mucus secretion
B.Increases airway mucus secretion
C.Makes respiratory secretions more watery
D.Stimulates mucociliary activity of bronchial epithelium
5. Antitussives act by:
A. Liquifying bronchial secretions
B. Raising the threshold of cough centre
C. Reducing cough inducing impulses from the lungs
D. Both ‘B’ and ‘C’ are correct
6. Dextromethorphan is an:
A.Analgesic
B.Antitussive
C. Expectorant
D.Antihistaminic
7. Which of the following is not an antitussive:
A.Oxeladin
B.Clophedianol
C.Dextropropoxyphene
D.Dextromethorphan
8. The following antitussive is present in opium but has no analgesic or addicting properties:
A.Noscapine
B. Codeine
C.Pholcodeine
D.Ethylmorphine
9. Which of the following ingredients has neither specific antitussive nor expectorant nor bronchodilator action, but is commonly present in proprietary cough formulations:
A.Ambroxol
B.Chlorpheniramine
C.Guaiphenesin
D.Noscapine
10. Bronchodilators are useful in cough:
A.Only when cough is nonproductive
B.Only when cough is associated with thick sticky secretions
C.Only when reflex bronchoconstriction is associated
D.Irrespective of nature of cough or associated features
11. The following antiasthma drug is not a bronchodilator:
A.Ipratropium bromide
B.Theophylline
C.Formoterol
D.Sodium chromoglycate
12. The most prominent and dose related side effect of salbutamol is:
A.Rise in blood pressure
B.Muscle tremor
C. Hyperglycaemia
D.Central nervous system stimulation
13. The following class(es) of drugs are clinically beneficial in bronchial asthma:
A.Histamine H1 receptor antagonists
B.Platelet activating factor (PAF) antagonists
C.Leukotriene (cys LT1) receptor antagonists
D.All of the above
14. Select the fastest acting inhaled bronchodilator:
A.Ipratropium bromide
B.Formoterol
C.Salbutamol
D.Salmeterol
15. In a patient of bronchial asthma, inhaled salbutamol produces the following effect(s):
A.Inhibits antigen-antibody reaction in the lungs
B.Causes bronchodilatation
C.Reduces bronchial hyperreactivity
D.Both ‘B’ and ‘C’ are correct
16. Inhaled salbutamol is useful in bronchial asthma for:
A.Aborting/terminating asthma attacks
B.Round the clock prophylaxis of asthma
C.Status asthmaticus
D.All of the above
17. Select the correct statement about salmeterol:
A. It is a long acting selective β2 agonist bron- chodilator
B.It is a bronchodilator with anti-inflammatory property
C.It is a β blocker that can be safely given to asthmatics
D.It is an antihistaminic with mast cell stabilizing property
18. Which of the following β2 agonist bronchodilators is given by inhalation, and is suitable for both termi-nating asthma attacks as well as for twice daily prophylaxis:
A.Terbutaline
B.Bambuterol
C.Salmeterol
D.Formoterol
19. Caffeine is more powerful than theophylline in exert-ing the following action:
A.Bronchodilatation
B.Cardiac stimulation
C. Diuresis
D.Augmentation of skeletal muscle contractility
20. The following vascular bed is constricted by caffeine:
A.Coronary
B.Cutaneous
C.Cranial
D.Mesenteric
21. Methylxanthines exert the following action(s) at cellular/molecular level:
A.Intracellular release of Ca2+
B.Antagonism of adenosine
C.Inhibition of phosphodiesterase
D.All of the above
22. Choose the correct statement about theophylline:
A.Its use in asthma has declined because of narrow safety margin
B.Its dose needs to be reduced in smokers
C.It acts by increasing the formation of cAMP
D.Its plasma halflife is longer in children com- pared to that in adults
23.Choose the correct statement about bambuterol:
A.It is an orally acting bronchodilator
B.It is a prodrug
C.It inhibits the enzyme pseudocholinesterase
D.All of the above
24. Relatively higher dose of theophylline is required to attain therapeutic plasma concentration in:
A.Smokers
B.Congestive heart failure patients
C.Those receiving erythromycin
D.Those receiving cimetidine
25. Which of the following drugs inhibits theophylline metabolism and raises its plasma concentration:
A.Phenytoin
B. Ciprofloxacin
C. Levofloxacin
D.Rifampicin
26. Select the antiasthma drug which cannot be administered by inhalation:
A.Theophylline
B. Ipratropium bromide
C.Budesonide
D.Terbutaline
27. Theophylline is believed to benefit asthma patients by exerting the following actions except:
A.Bronchodilatation
B. Augmentation of diaphragmatic contractility
C.Reduced mediator release
D.Inhibition of antigen: antibody reaction
28. Montelukast produces the following action(s) in bronchial asthma patients:
A.Bronchodilatation
B.Suppression of bronchial hyperreactivity
C.Stabilization of mast cells
D.Both ‘A’ and ‘B’
29. In comparison to inhaled β2 adrenergic agonists, the inhaled anticholinergics:
A.Are more effective in bronchial asthma
B.Are better suited for control of an acute attack of
asthma
C.Produce slower response in bronchial asthma
D.Produce little benefit in chronic obstructive lung disease
30. Select the most appropriate drug for regular prophylactic therapy in a 10 year old child who suffers from exercise induced asthma:
A.Oral salbutamol
B.Oral theophylline
C.Inhaled sodium cromoglycate
D.Inhaled salmeterol
31. Choose the correct statement(s) about ipratropium bromide:
A.It preferentially dilates peripheral bronchioles
B.It produces additional bronchodilatation when added to nebulized salbutamol
C.As metered dose inhaler it is used for terminating asthma attacks
D.Both ‘B’ and ‘C’
32. Sodium cromoglycate has a role in the treatment of the following conditions except:
A.Chronic bronchial asthma
B.Chronic urticaria
C.Chronic allergic rhinitis
D.Chronic allergic conjunctivitis
33. Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity:
A.Sodium cromoglycate
B. Ketotifen
C.Beclomethasone dipropionate
D.Chlorpheniramine
34. Leukotriene antagonists are used in bronchial asthma:
A.For terminating acute attacks
B.As monotherapy in place of β2 agonists
C.As adjuvants to β2 agonists for avoiding corticosteroids
D.As nebulized powder in refractory cases
35. The most consistent, pronounced and sustained relief of symptoms in chronic bronchial asthma is afforded by:
A. β2 sympathomimetics
B.Anticholinergics
C.Sodium cromoglycate
D.Corticosteroids
36. Systemic corticosteroids are indicated in the following conditions except:
A.Mild episodic asthma
B.Severe chronic asthma
C.Status asthmaticus
D.To prevent neonatal respiratory distress syndrome
37. Intranasal spray of budesonide is indicated in:
A.Common cold
B.Acute sinusitis
C.Perennial vasomotor rhinitis
D.Epistaxis
38. In patients of bronchial asthma inhaled corticoste-roids achieve the following except:
A.Reduce the need for bronchodilator medica- tion
B.Control an attack of refractory asthma
C.Reduce bronchial hyperreactivity
D.Reverse diminished responsiveness to sym- pathomimetic bronchodilators
39. Inhaled beclomethasone dipropionate should be used only in:
A.Acute attack of asthma
B.Moderate to severe chronic asthma
C.Status asthmaticus
D.Asthma not responding to systemic corti- costeroids
40. Budesonide is a:
A.Nonsteroidal antiinflammatory drug
B.High ceiling diuretic
C.Inhaled corticosteroid for asthma
D.Contraceptive
41. One of the most common side effect of inhaled beclomethasone dipropionate is:
A.Pneumonia
B.Oropharyngeal candidiasis
C.Atrophic rhinitis
D.Pituitary-adrenal suppression
42. In an asthma patient treated with systemic corti-costeroids, bronchodilator drugs:
A.Are not needed
B.Are contraindicated
C.May be used on ‘as and when required’ basis
D.Are ineffective
43. Reflex bronchoconstriction is most likely to occur with the following form of inhaled antiasthma medica-tion:
A.Metered dose spray of drug in solution
B.Dry powder rotacap
C.Nebuliser
D.Nebuliser with spacer
44. Choose the correct statement(s) about inhaled glucocorticoids in chronic obstructive pulmonary disease (COPD):
A.They are indicated in COPD only for severe/ advanced cases
B.Instituted early they retard the progression of COPD
C.Their use predisposes to respiratory infections
D.Both ‘A’ and ‘B’
45. To be a useful inhaled glucocorticoid the drug should have:
A.High oral bioavailability
B.Low oral bioavailability
C.Additional bronchodilator activity
D.Prodrug character
46. A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclo-methasone dipropionate 200 μg 4 times a day. What should be done to the oral prednisolone medication after starting inhaled beclomethasone:
A.It should be stopped immediately
B.Its dose should be tapered from the next day
C.It should be given at the same dose for one week and then tapered
D.Its dose should be doubled for one week and then tapered
47 The following component of management protocol of status asthmaticus has now been shown to be useless:
A.Intravenous aminophylline
B.Intravenous hydrocortisone
C.Nebulized salbutamol
D.Nebulized ipratropium bromide
