Physical pharmaceutics
SURFACE INTERFACIAL PHENOMENA
1). INTERFACE
2). LIQUID INTERFACE
3). MEASUREMENT OF SURFACE
INTER FACIAL TENSION
4). CAPILLARY RISE METHOD
5). RING (DU NOUY) TENSIOMETER
6). DROP WEIGHT AND DROP VOLUME METHOD
7). Surface active agent
8). Hydrophilic method
9). DETERMINATION OF HLB
10). FACTOR AFFECTING SPREADING COEFFICIENT
11). FUNCTIONAL CLASSIFICATION
12). STRUCTURAL CLASSIFICATION
13). SURFACTANT SHAPES IN COLLOIDAL
SOLUTION
14). Incompatibility involving surfactants
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COMPLEXATION AND
PROTEIN BINDING
1). COMPLEXATION
2). THE NATURE OF LIGANDS
3). COORDINATION COMPOUNDS
4). IMPORTANCE OF COMPLEX
5). LIGANDS
6). CHALATES
7). ORGANIC MOLECULAR COMPLEX
8). DRUG COMPLEX
9). POLYMER COMPLEX
10). INCLUSION COMPLEX
11). PROTEIN BINDING
12). METAL ION COORDINATION COMPLEXS
13). PLATINUM COMPLEXES
14). COPPER AND COBALT COMPEXES
15). ZINC COMPLEXES
16). TOXIC HEAVY METAL COMPLEXES
17). CYCLODEXTRIN COMPLEX
18). ION EXCHANGE RESINS
19). PORTION LIGAND INTERACTION
18). MECHANISMS OF INTERCATION
19). PLASMA PORTION BINDING
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Solubility of drug
1). Solubility and definition
2). Solubility expression
3). Ideal solubility parameters
4). affecting influencing solubility
5). Henry laws, route’s laws
6). Nerns’t distribution law
7). Functional distillation
FACTORS AFFECTING SOLUBILITY
1). SOLUBILITY
2). The nature of the solute and solvent
3). Temperature
4). Pressure (only applicable to gases)
5). PRESSURE
6). DISSOLVING
7). SURFACE AREA
8). STIRRING
9). TEMPERATURE
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Solubility gas in liquid & liquid in liquid
1). Diffusion Principles In Biological Systems.
2). Solubility Of Gas In Liquids,
• Factors Affecting Solubility Of Gas
3). Solubility Of Liquids In Liquids,
4). Binary Solutions,
5). Raoult’s Law
6). Ideal Solutions
7). Distribution Law
Solubility and Distribution Phenomena
1). SOLUTE-SOLVENT INTERACTIONS
2). FACTORS AFFECTING SOLUBILITY
3). RAOULT’S LAW
4). SALOL –THYMOL SYSTEM
5). SOLUBILITY OF GAS IN LIQUID
6). HENRY’S LAW
7). SOLUBILITY OF SOLID IN LIQUID
8). PARTITION COEFFICIENT (K)
9). APPARENT PARTITION COEFFICIENT
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Interfacial Phenomena
1). Classification of Interfaces
2). Liquid Interfaces
3). I n t e r f a c i a l Phenomena
4). Micelles
5). Hydrophile- Lipophile Balance [H LB]
6). Critical Micelle Concentration [CMC]
7). The concentration of the surface active agent affects
8). Types of Cationic Surface Active Agents
9). Zwitterion Surface Active Agents
10). Insoluble Monolayers at Liquid Surfaces
11). Langmuir Film Balance
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HYDROPHILIC –LIPHOPHILIC
BALANCED
1). Introduction
2). DEFINITION
3). DETERMINATION OF HLB
4). APPLICATIONS OF SURFACTANTS
DEPENDING ON HLB
5). HLB VALUE OF SOME SURFACTANTS
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COMPLEXATION
1). Definition and introduction of complex
2). Classification of complex
• metal complex
• inclusion complex
• organic molecular complex
3). Cheletes and legends
4). COMPLEXATION –Applications in pharmacy
6). Method of analysis
• Method of continuous variation.
• Distribution method
• Solubility method
• pH titration method.
Cyclo alkanes: Strain Theory
1). Baeyer’s Strain Theory
2). Limitation of Baeyer’s strain theory
3). Orbital Picture of Angle Strain
4). Coulson-Moffitt Model (Bent bond and Banana bond)
5). Sachse Mohr’s theory (Theory of strainless rings)
6). Strain (chemistry)
Protein binding of drugs
1). Introduction
2). Mechanisms of protein drug binding
3). Kinetics of protein drug binding
4).Classes of protein drug binding.
• Binding of drug to blood components.
(a) Plasma proteins
(b) Blood cells
• Binding of drug to extravascular tissue protein
5). Determination of Protein-drug Binding
6). Factors affecting protein drug binding
7). Significance of protein/tissue binding of drug
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Physical pharmaceutics IMP
1). Measurement of surfaces interfacial tension explain with various method.
2). Write short note:- HLB
3). Distribution law
4). Factor affecting of drug solubility
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