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Pharmaceutical Analysis- III With MCQs Answers

Pharmaceutical Analysis- III

Final Y. B. Pharmacy (Semester-VII)

Q No. 1) Reference compound used in NMR spectroscopy is
a) Silane
b) Trimethylsilane
c) Dimethylsilane
d) Tetramethylsilane

Q No. 2) Radiofrequency radiation is associated with
a) IR
b) Mass spectroscopy
c) UV
d) NMR

Q No. 3) Solvent commonly used in NMR is
a) Chloroform
b) Methanol
c) Acetone
d) Carbon tetrachloride

Q No. 4) Proton NMR is useful for investigating the structure of organic compounds because ____________
a) Organic compounds contain carbon atoms
b) Organic compounds are mostly covalent
c) Hydrogen atoms are found in nearly all organic compounds
d) Organic compounds have low boiling points

Q No. 5) In NMR spectroscopy radiation source used is
a) Radiofrequency source transmitter
b) Tungsten lamp
c) Xenon arc lamp
d) Mercury vapour lamp

Q No. 6) Unit of chemical shift ╬┤ is
a) Hz
b) Cps
c) Unit less
d) ppm

Q No. 7) Presence of electronegative atom on NMR spectra cause
a) Deshielding and upfield
b) Deshielding and downfield
c) Shielding and upfield
d) hielding and downfield

Q No. 8) Rotation of electrons about the protons generates a secondary magnetic field
which opposes the applied magnetic field. The proton is said to be.
a) Shielded
b) H-bonded
c) Deshielded
d) Shifted

Q No. 9) In NMR unit of coupling constant is
a) Cycle per second
b) Hertz
c) Both
d) None of the above

Q No. 10) Which is not a correct statement about chemical shift?
a) Depends on applied external magnetic field
b) Does not depend on applied external magnetic field
c) Dimensionless
d) Expressed in ppm

Q No. 11) In mass spectra, the most intense peak is the
a) Metastable ion peak
b) Fragment ion peak
c) Rearrangement ion peak
d) Base peak

Q No. 12) Principal involved in mass spectrometer is——-.
a) Excitation of electron
b) Electron impact bombardment
c) Molecular vibration
d) Splitting of electrons magnetic energy

Q No. 13) The inert gas used in the ionization stage of mass spectrometry is
a) Helium
b) rgon

c) Xenon
d) Methane
Q No. 14) M+1 peak occurs for which type of isotopes
a) 18C
b) 13C
c) 34S
d) 81Br

Q No. 15) Which of the fillowings detectors are used in Mass Spectroscopy
a) Photo tube
b) Photovolatic cell
c) Thermopile
d) Photomultiplier tube

Q No. 16) Which of the followings is graph plot is related to mass Spectroscopy
a) Relative abundance V/s Mass to charge ratio
b) % Transmittance V/s Wavenumber
c) Both
d) None of theses

Q No. 17) Mass spectrometer separates ions on the basis of which of the following?
a) Mass
b) Charge
c) Molecular weight
d) Mass to charge ratio

Q No. 18) In mass spectrometer, the sample gas is introduced into the highly evacuated
spectrometer tube and it is ionised by electron beam.
a) True
b) False

Q No. 19) Mass spectrometers are used to determine which of the following?
a) Composition in sample
b) Concentration of elements in sample
c) Relative mass of atoms
d) Properties of sample

Q No. 20) Which of following ionization technique is used in molecular weight
determination of large biomolecule by using mass?
a) Electron impact
b) Chemical ionization

d) None of the above

Q No. 21) Band broadening is:
a) Directly proportional to column efficiency
b) Inversely proportional to solvent efficiency
c) Directly proportional to solvent efficiency
d) Inversely proportional to column efficiency

Q No. 22) The number of theoretical plates depends on
a) Length of the column
c) Both (a) and (b)
d) None of the above

Q No. 23) In normal phase chromatography which compound is eluted first
a) More polar compound
b) Least polar compounds
c) Intermediate polar compound
d) Cannot say

Q No. 24) In gas chromatography sample must be in
a) Solid state
b) Gas state
c) Liquid state
d) Crystal

Q No. 25) Theoretical plates are used to—
a) Estimate the efficiency of a column
b) Determine the thickness of the stationary phase
c) Measure the distribution of the analyte between mobile and stationary phases
d) None of the above

Q No. 26) Which of the following gases is unsuitable for use as a GC carrier gas?
a) Nitrogen
b) Helium
c) Oxygen
d) All of the above

Q No. 27) Which of the following detector of gas chromatograph is destructive type?
a) Kathetormeter
b) Argon ionization detector
c) Flame ionization detector
d) Electon capture detector

Q No. 28) Indicate the HPLC detector that is most sensitive to change in temperature:
a) PDA detector
b) Refractive Index detector
c) Fluorescence detector
d) Electrochemical detector

Q No. 29) HPLC stands for
a) High Pressure Liquid Chromatography
b) High Performance Liquid Chromatography
c) both (a) and (b)
d) Highly Placed Liquid Chromatography

Q No. 30) Column diameter in HPLC is
a) 5-9 mm
b) 1-3 mm
c) 2-50mm
d) 10-50mm

Q No. 31) In size exclusion chromatography the stationary phase used are
a) Alumina
b) Dextrose
c) Agarose
d) Styrene

Q No. 32) Syringe pumps used in High pressure liquid chromatography are most suitable for which of the following columns?
a) Capillary columns
b) Guard columns
c) Short-fast columns
d) Small bore column

Q No. 33) Liquid chromatography can be performed in which of the following ways?
a) Only in columns
b) Only on plane surfaces
c) Either in columns or on plane surfaces
d) Neither in columns nor on plane surfaces

Q No. 34) In chromatography, which of the following can the mobile phase be made of?
a) Solid or liquid

b) Liquid or gas
c) Gas only
d) Liquid only

Q No. 35) Flame ionisation detector is also known as Katharometer.
a) True
b) False

Q No. 36) Which of following is used as a mobile phase in supercritical fluid?
a) Carbon dioxide
b) Water
c) Acetic acid
d) Both (a) and (b)

Q No. 37) What is the useful information can be found form a Van Deemeter plot ?
a) The Selectivity factor
b) Optimum mobile phase flow rate
c) Optimum column Temperture
d) Optimum column length

Q No. 38) Thermal analysis is defined as ___________.
a) Measurement of concentration of materials as a function of temperature
b) Measurement of solubility of materials as a function of temperature
c) Measurement of physical properties as a function of temperature
d) Measurement of line positions of crystals as a function of temperature

Q No. 39) What are the two main techniques for thermal analysis?
a) FTG & DGG
b) MSP & FCT
c) TGA & DTA
d) TSA & DGF

Q No. 40) Under conditions of ______________ heating, decomposition usually take place
in thermogravimetry. Fill up the suitable option from the choices given below.
a) First order
b) Second order
c) Third order
d) Dynamic

Q No. 41) Which of the following option is appropriate for the TGA and DTA?
a) TGA and DTA measures only weight
b) TGA measures only weight while DTA measures other effects
c) TGA and DTA measures only temperature
d) TGA measures only temperature while DTA measures other effects

Q No. 42) In the application of DTA and DSC which of the following parameters is
measured for the glasses?
a) Concentration of the glass
b) Solubility of the glass
c) Cooling temperature
d) Transition temperature

Q No. 43) DSC techniques is measure——-
a) Electrical conducitivity
b) Impact energy
c) Thermal Expansion
d) Specific heat

Q No. 44) DSC belongs to which kind of analytical method?
a) Spectroscopy
b) Thermal
c) Hyphenated
d) Chromatography

Q No. 45) Glass transition temperature is detected through
a) X-Ray diffractometery
b) Solution calonmetery
c) Differential scanning calorimeter
d) Thermogravimetric analysis

Q No. 46) Which of the following methods generally used for studying solid forms?
a) DSC
b) XRD
c) TGA
d) All the above

Q No. 47) In thermogravimetric analysis, the result obtained appear as a __________.
a) Continuous chart
b) Continuous parabola
c) Continuous circular positions

d) Discontinuous chart

Q No. 48) To identify and prepare the necessaey SOPs related to the control of quality is responsible of —– departement.
a) Production
b) QA
c) QC
d) None of theses

Q No. 49) Which departement is responsible for evaultion of Batch records?
a) QA
b) QC
c) Both a &b
d) None of theses

Q No. 50) ISO is a ——— organization
a) Non-governmental
b) Government
c) Semi-government
d) None of theses

Q No. 51) Iso 9000 was orginally published in—— year.
a) 1987
b) 1967
c) 1977
d) 1947

Q No. 52) The term GLP is most commonly associated with the———- industry.
a) Pharmaceutical
b) Petrochemical
c) Polymers
d) None of theses

Q No. 53) TQM aims at longs terms success through———.
a) Customer satisfaction
b) Owner satisfaction
c) Mangement satisfaction
d) All

Q No. 54) According to WHO QC is part of —————.
a) GLP
b) GCP
c) GMP

d) None of thes

Q No. 55) What is ISO
a) Indian organization for standard
b) International organization for standard
c) Internal organization for standard
d) None of the above

Q No. 56) ICH Q2 guideline is for ——–.
a) Cleaning validation
b) Calibration
c) Analytical validation
d) None of these

Q No. 57) The purpose of ICH is to make recommendation on ways to achive greater—–.
a) Quality
b) Harmonization
c) Safety
d) Optimization

Q No. 58) Which of the followings is an example of QA
a) Verfication
b) Docementation
c) Validation
d) Testing

Q No. 59) What is GLP?
a) Good Laboratory Practices
b) Good Label Practices
c) General Laboratory Practices
d) None of these

Q No. 60) GC chromatography techniques can be used for.
a) Qualitative analysis only
b) Quantitative analysis
c) Both
d) None of these