PHARMACOLOGY
51. Tick the group of hormonal drugs used for cancer treatment
a) Mineralocorticoids and glucocorticoids
b) Glucocorticoids and gonadal hormones
c) Gonadal hormones and somatotropin
d) Insulin
52. Rational combination of anticancer drugs is used to:
a) Provide synergism resulting from the use of anticancer drugs with different mechanisms combination
b) Provide synergism resulting from the use of anticancer drugs with the same mechanisms combination
c) Provide stimulation of immune system
d) Provide stimulation of cell proliferation
53. Tick the anticancer drug, a pyrimidine antagonist:
a) Fluorouracil
b) Mercaptopurine
c) Thioguanine
d) Methotrexate
54. Amiloride (Midamone) acts at this nephron site
a) Proximal convoluted tubule
b) Ascending thick limb of the loop of Henle
c) Distal convoluted tubule
d) Collecting duct
55. Tick the drug which belongs to nonnucleoside reverse transcriptase inhibitors
a) Zidovudine
b) Vidarabine
c) Nevirapine
d) Gancyclovir
56. All of the following antiviral drugs are antiretroviral agents, EXCEPT:
a) Acyclovir
b) Zidovudine
c) Zalcitabine
d) Didanozine
57. Tick the drug used for influenza A prevention:
a) Acyclovir
b) Rimantadine
c) Saquinavir
d) Foscarnet
58. Tick the drug used for HIV infection treatment, a derivative of nucleosides
a) Acyclovir
b) Zidovudine
c) Gancyclovir
d) Trifluridine
59. Tick the antiviral drug which belongs to endogenous proteins
a) Amantadine
b) Saquinavir
c) Interferon alfa
d) Pencyclovir
60. All of the following antiviral drugs are anti-influenza agents, EXCEPT:
a) Acyclovir
b) Amantadine
c) Interferons
d) Rimantadine
61. Find out the unwanted effects of zidovudine
a) Hallucinations, dizziness
b) Anemia, neutropenia, nausea, insomnia
c) Hypertension, vomiting
d) Peripheral neuropathy
62. Find out the unwanted effects of intravenous acyclovir infusion:
a) Renal insufficiency, tremors, delerium
b) Rash, diarrhea, nausea
c) Neuropathy, abdominal pain
d) Anemia, neutropenia, nausea, insomnia
63. Drug that can induce peripheral neuropathy and oral ulceration
a) Acyclovire
b) Zalcitabine
c) Zidovudine
d) Saquinavir
64. drug that can induce nausea, diarrhea, abdominal pain and rhinitis:
a) Acyclovire b) Zalcitabine
c) Zidovudine d) Saquinavir
65. All effects are disadvantages
of anticancer drugs, EXCEPT
a) Low selectivity to cancer cells
b) Depression of bone marrow
c) Depression of angiogenesis
d) Depression of immune system
66. The anticancer alkylating drug, a derivative of chloroethylamine
a) Methotrexate
b) Cisplatin
c) Cyclophosphamide
d) Carmustine
67. Tick the anticancer alkylating drug, a derivative of ethylenimine
a) Mercaptopurine
b) Thiotepa
c) Chlorambucil
d) Procarbazine
68. The anticancer drug of plant origin:
a) Dactinomycin
b) Vincristine
c) Methotrexate
d) Procarbazine
69. the anticancer alkylating drug, a derivative of alkylsulfonate
a) Fluorouracil
b) Carboplatin
c) Vinblastine
d) Busulfan
70. Action mechanism of alkylating agents?
a) Producing carbonium ions altering protein structure
b) Producing carbonium ions altering DNA structure
c) Structural antagonism against purine and pyrimidine
d) Inhibition of DNA-dependent RNA
synthesis
71. Methotrexate is
a) A purine antagonist
b) A folic acid antagonist
c) An antibiotic
d) An alkylating agent
72. The antibiotic for cancer chemotherapy?
a) Cytarabine
b) Doxorubicin
c) Gentamycin
d) Etoposide
73. The action mechanism of anticancer drugs belonging to plant alkaloids
a) Inhibition of DNA-dependent RNA synthesis
b) Cross-linking of DNA
c) Mitotic arrest at a metaphase
d) Nonselective inhibition of aromatases
74. General contraindications for
anticancer drugs are
a) Depression of bone marrow
b) Acute infections
c) Severe hepatic and/or renal insufficiency
d) All of the above
75. Action mechanism of methotrexate is
a) Inhibition of dihydrofolate reductase
b) Activation of cell differentiation
c) Catabolic depletion of serum asparagine
d) All of the above
76. The anticancer drug belonging to
inorganic metal complexes
a) Dacarbazine
b) Cisplatin
c) Methotrexate
d) Vincristine
77. The indication for estrogens in
oncological practice
a) Leukemia
b) Cancer of prostate
c) Endometrial cancer
d) Brain tumors
78. All of the following drugs are derivatives of nitrosoureas, EXCEPT:
a) Carmustine
b) Romustine
c) Lomustine
d) Semustine
79. Tick the estrogen inhibitor
a) Leuprolide b) Tamoxifen
c) Flutamide d) Anastrozole
80. The antiandrogen drug:
a) Flutamide
b) Aminoglutethimide
c) Tamoxifen
d) Testosterone
81. The drug belonging to aromatase inhibitors
a) Octreotide
b) Anastrozole
c) Flutamide
d) Tamoxifen
82. The drug belonging to gonadotropinreleasing hormone agonists
a) Leuprolide
b) Tamoxifen
c) Flutamide
d) Anastrozole
83. Which of the following local anesthetics is an useful antiarrhythmic agent?
a) Cocaine
b) Lidocaine
c) Bupivacaine
d) Ropivacaine
84. Indicate the route of local anesthetic administration, which is associated with instillation within epidural or subarachnoidspaces
a) Topical anesthesia
b) Infiltrative anesthesia
c) Regional anesthesia
d) Spinal anesthesia
85. The choice of a local anesthetic for specific procedures is usually based on
a) The duration of action
b) Water solubility
c) Capability of rapid penetration through the skin or mucosa with limited tendency to diffuse away from the site of application
d) All of the above
86. Which of the following local anesthetics is a short-acting drug?
a) Procaine b) Tetracaine
c) Bupivacaine d) Ropivacaine
87. The anesthetic effect of the agents of short and intermediate duration of action cannot be prolonged by adding
a) Epinephrine
b) Norepinephrine
c) Dopamine
d) Phenylephrine
88. A vasoconstrictor does not
a) Retard the removal of drug from the injection site
b) Hence the chance of toxicity
c) Decrease the blood level
d) Reduce a local anesthetic uptake by the nerve
89. Which of the following local anesthetics is only used for surface or topical anesthesia?
a) Cocaine
b) Tetracaine
c) Procaine
d) Bupivacaine
90. Which of the following local anesthetics is used for infiltrative and regional anesthesia?
a) Procaine
b) Lidocaine
c) Mepivacaine
d) All of the above
91. Indicate the local anesthetic, which is used for spinal anesthesia:
a) Tetracaine
b) Cocaine
c) Dibucaine
d) Bupivacaine
92. Most serious toxic reaction to local anesthetics is
a) Seizures
b) Cardiovascular collapse
c) Respiratory failure
d) All of the above
93. Which of the following local anesthetics is more cardiotoxic?
a) Procaine b) Bupivacaine
c) Lidocaine d) Mepivacaine
94. Most local anesthetics can cause
a) Depression of abnormal cardiac pacemaker activity, excitability, conduction
b) Depression of the strength of cardiac contraction
c) Cardiovascular collapse
d) All of the above
95. Which one of the following local anesthetics causes methemoglobinemia?
a) Prilocaine
b) Procaine
c) Lidocaine
d) Ropivacaine
96. Procaine has all of the following properties EXCEPT
a) It has ester linkage
b) Its metabolic product can inhibit the action of sulfonamides
c) It readily penetrates the skin and mucosa
d) It is relatively short-acting
97. Correct statements concerning lidocaine include all, EXCEPT
a) It is an universal anesthetic
b) It has esteratic linkage
c) It widely used as an antiarrhythmic agent
d) It is metabolized in liver
98. Which of the following alfa receptor antagonists is useful in reversing the intense local vasoconstriction caused byinadvertent infiltration of norepinephrine into subcutaneous tissue during intravenous administration?
a) Propranolol
b) Phentolamine
c) Tamsulosin
d) Ergotamine
99. Indicate an alfa receptor antagonist, which is an efficacious drug in the treatment of mild to moderate systemichypertension
a) Phentolamine
b) Tolazoline
c) Ergotamine
d) Prazosin
100. Beta-blocking drugs-induced chronically lower blood pressure may be associated with theirs effects on
a) The heart
b) The blood vessels
c) The renin-angiotensin system
d) All of the above
