Physicochemical properties in relation to biological action MCQs With Answers

Chapter – 2 Physicochemical properties in relation to biological action MCQS with Answer

1. The most important physicochemical properties affecting drug action-
a) Partition coefficient b) Solubility c) Acid base properties d) Chemical bonding e) Chelation f) Surface activity
A. All of the above
B. A and B both
C. D and E both
D. C and F both
Ans. A2. In QSAR, study of medicinal chemistry Q stands for-
A. Qualitative
B. Quantitative
C. Both
D. Quantam
Ans. B3. Dimercaprol is a chelating agent used in the treatment of-
A. Arsenic poisoning
B. Lead poisoning
C. Iron poisoning
D. Vanadium poisoning
Ans. A4. The non-polar compound dispersed
A. By forming hydrogen bonding
B. By interacting with lipid
C. By forming drug receptor complex
D. by forming hydrophilic bond
Ans. B5. pka is a parameter which indicates the-
A. Strength of drug as acid base reaction in water
B. Aqueous phase in phosphate buffer
C. Hydrophilic and lyphophilic character
D. All of the above
Ans. D6. 85% of drugs are ionizied in which pHA. 2-5
B. 7-12
C. 1.5-8
D. Neutral
Ans. C7. Bioisoterism is the process of-
A. Replacement similar group
B. Replacement similar valence group
C. Replacement similar mass no. group
D. Addition of group having different mass no.
Ans. B8. A drug like phenytoin & barbiturate when pka is larger than 7 is-
A. Ionised at all pH
B. unionised at pH
C. Ionised at pH 8
D. Unionised at pH 6
Ans. D9. A drug where pka is 7 & unionised at all pH it is-
A. Weak acidic
B. Very weak acidic
C. Weak basic
D. Very weak basic
Ans. B10. Dissolution & pka helps in drug-
A. ionization & solubility
B. dissociation & transportation
C. Dissociation & solubility
D. None of these
Ans. C11. Bioisosteres are similar in their-
A. Physical character
B. Chemical character
C. Both character a & b
D. Biochemical character
Ans. C12. Which of the following is not a bivalent?
A. CO
B. CS
C. CC
D. SH
Ans. D13. A molecule having 3 chiral centre carbon it has-
A. 4 set of diasters
B. 9 set of enantiomers
C. 6 set of monomers
D. 9 set of diasters
Ans. B14. The 3D structure elucidation is done by process-
A. IR
B. FTIR
C. NMR
D. MS
Ans. C15. Which of the following is odd one regarding drug-receptor interaction-
A. Hydrogen bonding
B. Electrostatic
C. Weak Wander wall Force
D. Dipole- induced dipole interaction
Ans. D16. Which of the following is a fastest receptor-
A. Enzyme linked
B. Ion- gated
C. GPCR
D. Nuclear
Ans. C17. Which of the following is not an optically isomer-
A. Enantiomers
B. Epimers
C. DisastersD. Meso
Ans. A18. Enantiomer has a higher affinity to receptor are called-
A. Eudismic
B. Diastomer
C. Eutomer
D. None of these
Ans. A19. Which type of hydrogen bonding present when hydrogen bonding occurs between molecules?
A. Intramolecular
B. Intermolecular
C. A & B both
D. None of them
Ans. B20. Which compound is capable of forming a ring structure with metal atoms?
A. Ligands
B. Chelates
C. Surfactants
D. All of the above
Ans. B21. For dissolution of solute in solvent which condition is necessary?
1. Solute-solvent interaction should be less than solute-solute and solvent-solvent interaction
2. Solute-solvent interaction should equal solute-solute and solvent-solvent interaction
3. Solute-solvent interaction should exceed solute-solute and solvent-solvent interaction
A. 1 & 2
B. 2 & 3
C. 1 & 3
D. 1, 2 & 3
Ans. B22. Addition of polar group in a drug increases its interaction with
A. Water
B. LipidC. Both
D. None
Ans. A23. Methyl Prednisolone is water insoluble but its which salt is water soluble?
A. Sodium
B. Hydrochloride
C. Salicylate
D. Palmitate
Ans. A24. Phenobarbitone is water insoluble but its which salt is water soluble?
A. Sodium
B. Hydrochloride
C. Salicylate
D. Palmitate
Ans. A25. Which ester of Chloramphenicol is prepared to mask its bitter taste?
A. Sodium
B. Hydrochloride
C. Salicylate
D. Palmitate
Ans. D26. Generally drugs are absorbed in which form?
A. In ionized form
B. In unionized form
C. In both of abone form
D. In none of above form
Ans. B27. Most weakly acidic drugs (pKa < 2) are absorbed from
A. Stomach
B. Intestine
C. Stomach and Intestine
D. They Can’t be absorbed
Ans. A28. Most weakly basic drugs (pKa > 8) are absorbed fromA. Stomach
B. Intestine
C. Stomach and Intestine
D. They Can’t be absorbed
Ans. B29. Absorption of neutral drugs (pKa 6- 8) is independent of pH.
A. True
B. False
Ans. A30. Which form of barbituric acid has CNS activity?A. 1
B. 2
C. 3
D. All
Ans. CExplanation: barbituric acid (1) and its 5-monosubstituted (2) derivatives are inactive and lack the CNS activity while 5,5-disubstituted derivatives (3) are CNS depressants. This is due to the fact that (1) and (2) are stronger acids and are able to achieve complete aromatic
structure which can stabilize the barbiturates ion by delocalization of extra pair of electrons. On the other hand 5,5 disubstituted barbiturates (3) cannot assume fully aromatic structure
and therefore are much weaker acid (pKa 7.0-8.5) therefore it remains largely in unionized form at physiological pH and cross the blood brain barrier in contrast to barbituric acid and its 5-monosubstituted derivative which remains in ionic form at physiological pH and does not able to cross blood brain barrier.31. Addition of non-polar group _________ partition co-efficient
A. Improves
B. Reduces
C. No effect on
Ans. A32. Gentamicin, streptokinase can be given
A. Orally
B. Parentrally
C. Both of above
D. None of above
Ans. B33. Distance between H-bond is
A. 2.3- 5.2 A°
B. 1.2 – 2.5 A°
C. 2.5 – 3.2 A°
D. 3.2 – 8.5 A°
Ans. C34. Angel of H-bond
A. 1.3 – 1.8°
B. 13-18°
C. 130 – 180 °
D. 1300 – 1800 °
Ans. C35. Strength of H-bond is
A. 1-7 Kcal/mol
B. 10-70 Kcal/mol
C. 10-17 Kcal/mol
D. 17-70 Kcal/mol
Ans. A36. p-nitrophenol contains
A. Intramolecular H-bond
B. Intermolecular H-bond
C. Both of above
D. None of above
Ans. B37. Which one of the following factors related to protein-drug binding is not related to drugs?
A. Physicochemical characteristics of a drug
B. The concentration of the drug in the body
C. The affinity of the drug for binding
D. Number of binding sites on the binding agentAns. D
(Explanation: There are many factors affecting protein-drug binding. The factors related to the drug, are physicochemical characteristics of a drug, concentration of the drug in the body, affinity of the drug for binding. A number of binding sites on the binding agent are related to the protein and other binding components.)38. Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
A. Competition between the drug and the binding site
B. Competition between drugs and normal body constituents
C. Allosteric changes in a protein molecule
D. Inter subject variation
Ans. D
(Explanation: Competition between the drug and the binding site, competition between drugs and normal body constituents, allosteric changes in protein molecule these factors are related to drug interactions. Inter subject variation is a patient-related factor.)39. Which of the following factors for protein drug binding is a drug interaction factor?
A. Competition between drugs for the binding site
B. Age
C. Physicochemical characteristics of a drug
D. Physicochemical characteristics of the protein or binding agent
Ans. A
(Explanation: Physicochemical interaction is not a drug interaction factor. Competition between the drug and the binding site and competition between drug and other normal body constituents, allosteric changes in protein molecule all these factors are related to drug interaction with the protein. Age is a patient-related factor.)40. Only unbound or free drug is capable of being eliminated.
A. True
B. False
Ans. A
(Explanation: Unbound or free drug is capable of being eliminated. Because the drug- protein complex cannot penetrate into the metabolizing organ. The large molecular size of the complex also prevents it from getting filtered through the glomerulus.)41. Plasma proteins bound with drugs by formation of
A. Hydrogen bonding
B. Hydrophobc bonding
C. Vander-waals forceD. Ionic interaction
E. All
Ans. E42. The most significant protein involved in binding with a drug is
A. Albumin
B. Glycoprotein
C. Lipoprotein
D. Globulin
Ans. A
(The order of binding of drugs to various protein is Albumin > Glycoprotein >
Lipoprotein > Globulin)43. The most abundant plasma protein is
A. Albumin (HAS – Human serum albumin)
B. Glycoprotein
C. Lipoprotein
D. Globulin
Ans. A44. Chelating agent Dimercaprol is used in the treatment of
A. Lead poisoning
B. Vanadium poisoning
C. Arsenic poisoning
D. All of above
Ans. C45. In Lead and vanadium poisoning, which chelating agent is used as an antidote?
A. Disodium EDTA
B. Haemoglobin
C. Cyanocobalamine
D. Dimercaprol
Ans. A46. Absorption of Tetracycline is reduced in the presence of milk because of
A. Hydrogen bonding
B. Protein binding
C. Ionization
D. Chelation
Ans. D47. Functional groups of same valance and ring equivalents are known as
A. Classical Bioisosteres
B. Non- Classical Bioisosteres
C. Enantiomer
D. Geometric isomer
Ans. A48. Bioisosteres have
A. Same physical properties
B. Same chemical properties
C. Similar biological properties
D. All of above
Ans. D49. R (-) Epinephrine shows 3 point of interaction with receptor while S (+)Epinephrine shows 2 point of interaction with receptor.
A. True
B. False
Ans. A50. (+) Warfarin is _____times more potent than (-) Warfarin.
A. 2
B. 3
C. 4
D. 5
Ans. D51. (+) Sotalol is beta blocker while (-) Sotalol is
A. beta blocker
B. Analgesic
C. Antidepressant
D. Antiarrhythmic
Ans. D
Table to remember for similar questions:52. D-Penicillamine is antiarthritic while L-Penicillamine is
A. Antiarthritic
B. Antiarrhythmic
C. Antidepressant
D. Toxic
Ans. D
To remember for similar questions:53. D-Asparagine has sweet taste while L-Asparagine has
A. Sweet taste
B. Sour Taste
C. Bitter Taste
D. Tasteless
Ans. D
To remember:Subject:- Medicinal chemistry 1Topic:- Physicochemical properties in relation to biological action (Unit:- 2 MCQs)