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pharmacyTopic wise MCQs

PRE-GPAT Preparation MCQs (Part:- 11) with Answers


Q.51 The rate of lecithin to sphingomyelin in amniotic fluid is measured
a) To obtain neonatal lipid profile
b) To assess fetal maturity and respiratory distress Syndrome
c) To obtain age of the fetus
d) As a diagnostic marker of Tay-Sach’s disease

Q.52 Metabolites that could transiently accumulate as a result of inhibition of squalene synthase are
a) Dimethyl allyl pyrophosphate b) farnesyl pyrophosphate
c) Isopentenyl Pyrophosphate d) All of these

Q.53 The deficiency of Glucose-6-phosphate dehydrogenase is characterized by disease

  1. a) Phenylketonurea
  2. b) Scrapie
  3. c) β-Thalassemia
  4. d) Haemolytic anemia

Q.54 Aminotransferase are directly involved in the biosynthesis of

  1. a) Aspartate
  2. b) Alanine
  3. c) Both a & b
  4. d) None of these

Q.55 ‘Ternary complex’ refers to the state when
a) An enzyme forms a covalent complex with its substrate
b) An enzyme forms a non-Covalent complex with either a substance or a product
c) An enzyme that catalyses a reaction with two or more substrates, is concurrently complexed with both substrates
d) An enzyme complexed to a product, just after catalysis

Q.56 The most important clue that helped in the determination of the double helical Structure of DNA came from
a) Chargaff’s rules
b) Hershey-Chase experiment
c) Avery-MacLeod-McCarty Experiment
d) Nirenberg and Khorana’s codon assignments

Q.57 Diversity in antibody molecules is brought about by
a) Post-translational modifications
b) Gene rearrangements
c) Usage of special genetic codes
d) Multiple mutations in the polypeptides

Q.58 the etiological agent of Progressive multifocal leukoencephalopathy, also associated with a form of salivary gland infection is

  1. a) Varicella Zoster Virus
  2. b) Epstein Barr Virus
  3. c) Picorna Virus
  4. d) Papovavirus

Q.59 Estimation of creatinine is done by

  1. a) Kjeldal method
  2. b) Sakaguchi method
  3. c) Folin method
  4. d) Doremus

Q.60 Glycine + Benzoic acid gives

  1. A) Salicylic acid
  2. b) Indicin
  3. c) Hippuric acid
  4. d) Bilirubin

Q.61 The deficiency of glucose-6-Phosphatase is known as……disease.

  1. a) Von Gierke’s
  2. b) Pompe’s
  3. c) Limit dextrinosis
  4. d) Amylopectinosis

Q.62 In the study of enzyme kinetics, Vmax is said to be attained when
a) There is an excess of free enzyme as compared to the substrate
b) Virtually all of the enzyme is present as the enzyme-substrate complex and concentration of the free enzyme is vanishingly small
c) The maximum velocity of the reaction in the presence of low substrate concentration
d) When the concentration of free enzyme equals that of the enzyme-substrate complex

Q.63 Serum sample of a patient shows elevated levels of γ-glutamyl transferase. The Patient could be suffering from

  1. a) Kidney disorder
  2. b) Liver disorder
  3. c) Parkinson’s disease
  4. d) Myocardial infarction

Q.64 In diphtheria where pathogenesis is because of toxin & the level of immunity is assayed by

  1. a) Sham test
  2. b) Shick test
  3. c) VDRL test
  4. d) Kahn’s test

Q.65 Gene transformation from one bacteria to another bacteria is called as

  1. a) Transduction
  2. b) Translation
  3. c) Travelling
  4. d) Trading

Q.66 Autoimmunity refers to
a) An automatic trigger of immune system directed against a specific pathogen
b) Failure to distinguish between self and non-self
c) An automatic segregation of T and B cells
d) Failure of B-cells to interact with T-cells

Q.67 in Protein biosynthesis, each amino acid
a) Recognizes its own codon by a direct interaction with the m-RNA template
b) Is added in its proper place to a growing peptide chain through “adaptor” function of t-RNA
c) Is first attached to an anticodon specific for amino acid
d) Undergoes fidelity translation which is assured by presence of traces of DNA on the ribosome

Q.68 Rabies’ Antiserum I.P. is
a) A freeze dried preparation containing antitoxin globulin
b) A preparation containing specific globulin or its derivatives obtained by purification of hyper immune serum of healthy horses
c) A sterile preparation containing antitoxic globulin
d) A sterile preparation containing antitoxic globulins obtained by purification of hyperimmune serum horses

Q.69 Out of the carbohydrates which one is exclusively used for kidney functioning test

  1. a) Lactose
  2. b) Sucrose
  3. c) Fructose
  4. d) Inulin

Q.70 Sequentor is
a) Automatic mechanism to determine glucose number
b) Automatic mechanism to determine amino acid
c) Automatic mechanism to determine mol. Wt.
d) None of these

Q.71 Exrachromosomal DNA which irreversibly integrate in the host DNA is called

  1. a) Plasmid
  2. b) mesosome
  3. c) episome
  4. d) none of these

Q.72 Exonucleases functions

  1. a) To remove nucleic acid only from the end of chain
  2. b) to remove sugar part of DNA
  3. c) To break bond within the DNA chain
  4. d) all of theses

Q.73 The movement of gene from one chromosome to another or from one site to different one on the same chromosome is called as

  1. a) Translation
  2. b) transposition
  3. c) transformation
  4. d) translocation

Q.74 Enzyme used for conversion of m-RNA into c-DNA is

  1. A) DNA polymerase
  2. b) DNA ligase
  3. c) Reverse transcriptase
  4. d) RNA polymerase

Q.75 Gene manipulation to modify germ cells of animals permanently is called

  1. a) Transgenesis
  2. b) transphoresis
  3. c) gene expression
  4. d) none of these

Q.76 resolving power of electron microscope is near about

  1. a) 1nm
  2. b) 0.1nm
  3. c) 0.01 nm
  4. d) 0.001 nm

Q.77 Antibody, which crosses the placental membrane, is

  1. a) IgA
  2. b) IgM
  3. c) IgG
  4. d) IgD

Q.78 In anchored polymerase chain reaction (PCR), many primers used

  • a) 1
  • b) 2
  • c) 3
  • d) 4

Q.79 Glycolysis occurs in

  1. a) Mitochondria
  2. b) Cytoplasm
  3. c) Golgi apparatus
  4. d) Endoplasmic reticulum

Q.80 In normal healthy adult, blood urea concentration is

  1. a) 20 mg/dL
  2. b) 60 mg/dL
  3. c) 80 mg/dL
  4. d) 100 mg/dL

Q.81 who is the father of “Immunology”?

  1. a) Edward Jenner
  2. b) Louis Pasteur
  3. c) Elie Metchnikoff
  4. d) Robert Koch

Q.82 Immunoglobulins that are agglutinating and cytolytic

  1. a) IgG
  2. b) IgA
  3. c) IgM
  4. d) IgE

Q.83 which one of the followings does not give positive Rothera test?

  1. a) Acetone
  2. b) Acetaldehyde
  3. c) Beta hydroxy butyrophenone
  4. d) Acetoacetate

Q.84 Arginine gives Positive …….test

  1. a) Rothera
  2. b) Hopkins
  3. c) Sakaguchi
  4. d) Million

Q.85 Hay sulfur test is used to detect the presence of

  1. a) Bile pigments
  2. b) Bile salts
  3. c) Both a & b
  4. d) none of these

Q.86 which one of these are not phospholipids

  1. a) Lecithin
  2. b) Cephalin
  3. c) Phosphatidyl ethanolamine
  4. d) Lycine

Q.87 High level of triglyceride is present in (nearly 90 %)

  1. a) VLDL
  2. b) LDL
  3. c) HDL
  4. d) none of these

Q.88 Gram (-) bacteria produces Endotoxins that are chemically

  1. a) Pyrogens
  2. b) Lipopolysaccharides
  3. c) Both a & b
  4. d) none of these

Q.89 Granulocyte-Macrophage Stimulating Factor (GM-CSF) is generated by

  1. a) Filagrastim
  2. b) Sargramostim
  3. c) Both a & b
  4. d) none of these

Q.90 Hyperthyroidsm is charactersitic of

  1. a) Cushing’s syndrome
  2. b) Addison’s disease
  3. c) Grave’s disease
  4. d) Crohn’s disease

Q.91 Wasserman’s test is related to one of the venereal disease

  1. a) Syphilis
  2. b) Gonorrhoea
  3. c) Both a & b
  4. d) none of these

Q.92 Neisseria gonorroeae is causative organism of Gonorrhoea. It is

  1. A) Gram (+) cocci
  2. b) Gram (-) cocci
  3. c) Gram (+) bacilli
  4. d) Gram (-) bacilli

Q.93 The spore of Bacillus steriothermophilus is used as biological indicator in

  1. a) Moist heat sterilization
  2. b) Filtration
  3. c) Dry heat sterilization
  4. d) none

Q.94 Borrelia recurrentis is causative organism for

  1. a) Plague
  2. b) Lyme disease
  3. c) Relapsing fever
  4. d) Dengue

Q.95 Pseudomonas dentrificants is source of

  1. a) Riboflavin
  2. b) Vitamin B12
  3. c) Ascorbic acid
  4. d) Amino acid

Q.96 which one of these micro organnism is not used in bioconversion?

  1. a) Acetobactor suboxydans
  2. b) Rhizopus arrhizus
  3. c) M. Tubrecle
  4. d) Curvularia lunata

Q.97 what is application of immobilized amino cyclase?

  1. a) N-oxidation of drugs containing hydrazine
  2. b) Resolution of DL-amino acids
  3. c) D-amino acid production
  4. d) L-amino acid production

Q.98 what is application of immobilized Flavoprotein oxidase?

  1. a) N-oxidation of drugs containing hydrazine
  2. b) Resolution of DL-amino acids
  3. c) D-amino acid production
  4. d) L-amino acid production

Q.99 Virulent Staphylococcus aureus can be identified by the given

  1. a) Coomb’s test
  2. b) Coagulase test
  3. c) Both a & b
  4. d) none of these

Q.100 which one organism is large bacilli, rectanglular and gram positive?

  1. a) Streptococci
  2. b) Sarcina
  3. c) Bacillus anthracis
  4. d) Vibrios and spirilla


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