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NursingpharmacyTopic wise MCQs

The Breast MCQs with Answers

1. Mammary duct ectasia is characterised by the following features except:
A. It affects women in 2nd to 3rd decade of life
B. There are dilated ducts containing inspissated secretions
C. There is periductal chronic inflammation
D. There may be presence of multinucleate giant cells

2. Out of the various epithelial hyperplasias in breast the most ominous is:
A. Papillary ductal hyperplasia
B. Florid ductal papillomatosis
C. Lobular hyperplasia
D. Epithelial hyperplasia of usual type

3. Tubular adenoma of breast is mainly composed of:
A. Closely-packed ductules
B. Ductal epithelial hyperplasia
C. Lobular hyperplasia
D. Lactational hyperplasia

4. Phyllodes tumour is distinguished from fibroadenoma by having:

  1. A. More ductal hyperplasia
  2. B. Compressed ducts
  3. C. More cellular stroma
  4. D. More lobular hyperplasia

5. Intraductal papilloma occurs most often in the following region:

  1. A. Collecting ducts
  2. B. Lactiferous ducts
  3. C. Terminal ducts
  4. D. Acini

6. Lobular carcinoma in situ has the following features except:
A. A palpable lump is generally present
B. After excision, about 25% cases develop ipsilateral invasive
cancer in 10 years
C. There is a higher incidence of bilaterality
D. The tumour cells are rather uniform and cohesive

7. The following type of carcinoma of the breast is characterised by ‘Indian file’ pattern of tumour cells:
A. Infiltrating duct carcinoma
B. Invasive lobular carcinoma
C. Medullary carcinoma
D. Tubular carcinoma

8. The following type of breast carcinoma is seen in children:
A. Papillary carcinoma
B. Adenoid cystic carcinoma
C. Secretory carcinoma
D. Metaplastic carcinoma

9. Paget’s cells in Paget’s disease of the breast are malignant cells of following type:

  1. A. Squamous cell carcinoma
  2. B. Basal cell carcinoma
  3. C. Melanoma
  4. D. Adenocarcinoma

10. Patients of breast cancer having high levels of oestrogen receptors imply:
A. Patient has an anaplastic breast cancer
B. Anti-oestrogen therapy will be helpful
C. Patient has an oestrogen-secreting ovarian tumour
D. Patient is likely to have poor prognosis

11. Men who have mutated BRCA 1 have increased risk of following cancer:
A. Male breast
B. Germ cell tumours of testis
C. Sex-cord-stromal tumour of testis
D. Carcinoma of prostate

12. What percentage of phyllodes tumours are malignant:

  1. A. 10%
  2. B. 20%
  3. C. 30%
  4. D. 40%

13. All are genetic mutations seen in breast cancer except:

  1. A. BRCA-1
  2. B. p53
  3. C. PTEN
  4. D. Rb

14. All are true about medullary carcinoma breast except:
A. Worse prognosis than IDC
B. Prominent lymphoid infiltrate
C. Bizarre and atypical mitosis
D. Soft and fleshy consistency

15. Which of the following feature is not used in modified Bloom-Richardson grading system for breast cancer?

  1. A. Tubule formation
  2. B. Nuclear pleomorphosis
  3. C. Mitotic count
  4. D. Tumour necrosis

16. HER2/neu overexpression in breast cancer:
A. Is a bad prognostic marker
B. Responds to herceptin therapy
C. Responds to tamoxifen
D. Is a serum marker for breast cancer

17. A 60 years old woman complains of itching and scaling of the right breast nipple area, which on biopsy is confirmed as Paget’s disease. On further work-up, a 2 cm in diameterpalpable mass is noted under the skin of the nipple. Which of the following is likely to be an association?
A. Infiltrating ductal carcinoma
B. Lobular carcinoma in situ
C. Invasive lobular carcinoma
D. Intraductal papilloma

18. Which of the following is the most common location for extra- mammary Paget disease?

  1. A. Uterus
  2. B. Cervix
  3. C. Vulva
  4. D. Penis

Answers Key
1) = A, 2) = C, 3) = A, 4) = C, 5) = B, 6) = A, 7) = B, 8) = C, 9) = D, 10) = B, 11) = D, 12) = B, 13) = D, 14) = A, 15) = D, 16) = B, 17) = A, 18) = C