The Musculoskeletal System MCQs with Answers

1. The serum marker for increased osteoclastic activity is:
A. Total acid phosphatase level
B. Bony acid phosphatase level
C. Total alkaline phosphatase level
D. Bony alkaline phosphatase level

2. The serum marker for increased osteoblastic activity is:
A. Total acid phosphatase level
B. Bony acid phosphatase level
C. Total alkaline phosphatase level
D. Bony alkaline phosphatase level

3. Mineralisation of uncalcified osteoid matrix takes about:

1. A. 3-5 days
2. B. 5-8 days
3. C. 8-12 days
4. D. 12-15 days

4. Cartilage matrix largely consists of:

1. A. Chondroitin sulfate
2. B. Keratan sulfate
3. C. Heparan sulfate
4. D. Dermatan sulfate

5. Long-term complications of chronic osteomyelitis are as follows except:
A. Secondary amyloidosis
B. Draining sinus tracts
C. Development of Ewing’s sarcoma
D. Squamous carcinoma in sinus tract

6. Osteopetrosis is characterised by the following features except:
A. Overgrowth of calcified dense bone
B. Hereditary defect in osteoclast function
C. There is hypercalcaemia
D. Skeleton is susceptible to fractures

7. Osteoporosis is characterised by the following laboratory investigations except:
A. Normal inorganic phosphate
B. Raised serum calcium
C. Normal alkaline phosphatase
D. Normal acid phosphatase

8. Renal osteodystrophy has the following biochemical parameters except:
A. Raised parathormone level
B. Hyperphosphataemia
C. Hypercalcaemia
D. Calcium phosphorus product >70

9. Paget’s disease of the bone has following features except:
A. Affects older age past 50 years
B. Elevation of serum alkaline phosphatase
C. There is generally hypocalcaemia
D. Role of virus in its etiology

10. Albright’s syndrome has the following features except:
A. There is monostotic bony lesion
B. Skin pigmentation
C. Sexual precocity
D. More common in females

11. Osteoblastoma differs from osteoid osteoma by the following features except:
A. It is larger than osteoid osteoma
B. It is generally painful
C. It is commonly located in the medulla of vertebrae, ribs, etc.
D. There is absence of reactive bone formation

12. Classic osteosarcoma has the following features except:
A. It occurs in age range of 10-20 years
B. There is role of mutation in Rb gene in its etiology
C. It is a highly malignant tumour
D. Serum alkaline phosphatase levels are generally lowered

13. Parosteal osteosarcoma has the following features except:
A. It occurs at extracortical location
B. It occurs in older age group
C. Worse prognosis than classic osteosarcoma
D. It has no sex predilection

14. There is a higher possibility of development of chondrosarcoma in the following benign cartilage-forming tumour:

1. A. Solitary enchondroma
2. B. Multiple enchondroma
3. C. Chondroblastoma
4. D. Chondromyxoid fibroma

15. In giant cell tumour of bone, the tumour cells are:

1. A. Osteoclastic giant cells
2. B. Mononuclear stromal cells
3. C. Fibroblastic cells
4. D. Sinusoidal lining cells

16. The cell of origin of Ewing’s sarcoma is:
A. Endothelial cell
B. Marrow cell
C. Osteoblast
D. Primitive neuroectodermal cell

17. Chordoma is a:

1. A. Benign tumour
2. B. Locally recurrent tumour
3. C. Intermediate grade tumour
4. D. Malignant tumour

18. Osteoblastic skeletal metastasis are characteristically seen in:

1. A. Thyroid cancer
2. B. Breast cancer
3. C. Prostatic cancer
4. D. Malignant melanoma

19. Osteoarthritis has the following pathologic changes except:
A. Progressive loss of cartilaginous matrix
B. Increased osteoclastic activity
C. Osteophyte formation at the joint margin
D. Atrophy of synovium

20. Most frequently and severely involved joints in rheumatoid arth-ritis are:

1. A. Knees
2. B. Elbows
3. C. Interphalangeal
4. D. Sacroiliac

21. Most frequently affected joint in acute gouty arthritis in the beginning is:

1. A. Knee
2. B. Elbow
3. C. Shoulder
4. D. Great toe

22. The origin of villonodular tenosynovitis and giant cell tumour of tendon sheath is:

1. A. Inflammatory
2. B. Neoplastic
3. C. Traumatic
4. D. Autoimmune

23. Patients of myasthenia gravis have the following features except:
A. There is reduction in AChRs
B. Majority of patients have anti-AChR antibodies in their serum
C. Thymic hypoplasia has a risk in its etiology
D. The disease has other autoimmune associations

24. All the following tumours are benign except:

1. A. Osteoma
2. B. Chondroma
3. C. Chordoma
4. D. Osteoblastoma

25. Most common etiologic agent implicated in chronic osteomyelitis is:

1. A. Staphylococcus aureus
2. B. Escherichia coli
3. C. Pseudomonas
4. D. Klebsiella

26. All are causes of avascular necrosis except:

1. A. Long-term steroid therapy
2. B. Chronic alcoholism
3. C. Radiation therapy
4. D. Fungal infection

27. All are types of skeletal dysplasia except:

1. A. Achondroplasia
2. B. Osteogenesis imperfecta
3. C. Osteoporosis
4. D. Osteopetrosis

28. All are benign bone forming tumours except:

1. A. Osteoma
2. B. Osteochondroma
3. C. Osteoid osteoma
4. D. Osteoblastoma

29. All of the following infectious agents are implicated in rheumatoid arthritis except:

1. A. CMV
2. B. Rubella
3. C. Mycoplasma
4. D. Mycobacterium

Answers Key

1) = B, 2) = D, 3) = D, 4) = A, 5) = C, 6) = C, 7) = B, 8) = C, 9) = C, 10) = A, 11) = B, 12) = D, 13) = C, 14) = B, 15) = B, 16) = D, 17) = D, 18) = C, 19) = D, 20) = C, 21) = D, 22) = B, 23) = C, 24) = C, 25) = A, 26) = D, 27) = C, 28) = B, 29) = D