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Thrombolytic Therapy:- PDF / PPT

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Thrombolytic Therapy
• • Discuss the main classification of thrombolytic therapy.
• Discus the action of different thrombolytic therapy
• Discuss the nursing responsibility during thrombolytic therapy
• Blood Components
• Erythrocytes
• Leukocytes
• Platelets
• Plasma
• What is coagulation of blood?
• What is Thrombosis?
• What is embolism?
• • Prothrombin: Prothrombin is a protein produced by the liver.
Prothrombin is present in blood plasma that is converted into active thrombin during coagulation.
• Prothrombin is converted into thrombin by a clotting factor
known as factor X or prothrombinase.
• Function of Thrombin: it is an enzyme that causes the clotting of
blood by converting fibrinogen to fibrin
• Prothrombin activator: Prothrombin activator is a complex of coagulation factors that functions in catalyzing prothrombin into thrombin
• Fibrinogen: Fibrinogen is the major plasma coagulation factor
• Antithrombin: it is a small protein molecule that inactivates several enzymes of the coagulation system. (Factors IIa, IXa, Xa).
• Stages of Blood Clotting
• Anticoagulants
(Heparin, Warfarin, Rivaroxaban)
• Heparin
• Heparin Pharmacokinetics
• Adverse Effects and Contraindications
• Congenital antithrombin III deficiency
• Protamine Sulfate for Heparin Overdose
• Factor X inhibitor
Rivaroxaban 2007
• Why new born babies are given Vitamin K?
• What is Warfarin ?
• Mechanism of action of warfarin
• Fibrinolytics
• Fibrinolysis
• Fibrin clot
• Formation of Plasmin
• Fibrinolytics or Thrombolytic drugs
• Mechanism of action of fibrinolytics
• Antiplatelets (aspirin, clopidogrel, and Prasugrel)
• Platelet activation step’s
• Adenosine diphosphate
• What is thromboxane?
• What is thromboxane A2?
• How do Clopidogrel and Aspirin act as antiplatelete?
• Glycoprotein IIb/IIIa Receptor Antagonists
• Tranexamic acid
• Tranexamic acid indications

  • Subject:- Pharmacology
  • Course:- B.pharm (pharmacy),
  • Semester:- 5th sem , sem :- 5

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