1. Transplantation antigens are located on portion of:
- A. Chromosome 1
- B. Chromosome 6
- C. Chromosome 9
- D. Chromosome 22
2. Class I HLA antigens are located on:
- A. All nucleated cells of the body
- B. B and T lymphocytes
- C. Macrophages
- D. Complement system
3. HIV contaminated waste products can be decontaminated by the following agents except:
- A. Sodium hypochlorite
- B. Methanol
- C. Formaldehyde
- D. Glutaraldehyde
4. CD4 bearing subpopulation of macrophages are attacked by HIV and cause the following except:
A. Cytopathic effects
B. Act as reservoir of HIV infection
C. Act as source of infection in nervous system
D. Defects in CD4+ T lymphocytes
5. In autoimmune haemolytic anaemia, the following type of immunologic tissue injury is involved:
A. Type I (anaphylactic)
B. Type II (cytotoxic)
C. Type III (immune complex)
D. Type IV (cell mediated)
6. Out of various antinuclear antibodies, pathognomonic of SLE is:
A. Antibody to single-stranded DNA
B. Antibody to double-stranded DNA
C. Antibody to histones
D. Antibody to nucleolar antigen
7. In cases of renal failure on long-term haemodialysis, there is development of following type of amyloid:
A. Amyloid light chain (AL)
B. Amyloid-associated protein (AA)
C. Amyloid b 2 microglobulin (Ab 2m)
D.b amyloid protein (Ab)
8. The most common form of amyloid in developing countries is:
A. Primary B. Secondary
C. Hereditary D. Localised
9. Cardiac amyloidosis often produces:
A. Dilated cardiomyopathy
B. Constrictive cardiomyopathy
C. Restrictive cardiomyopathy
D. Ischaemic cardiomyopathy
10. In senile cardiac amyloidosis, the biochemical form of amyloid is:
- A. AL
- B. AA
- C. ATTR
- D. Ab2M
11. In Alzheimer’s disease, cerebral plaques consist of:
- A. ATTR protein
- B. Ab2M protein
- C. Ab protein
- D. Prion protein
12. Amyloid enhancing factor (AEF) plays a significant role in:
A. Primary amyloid
B. Secondary amyloid
C. Senile cerebral amyloid
D. Haemodialysis-associated amyloid
13. Grave’s disease is a type of:
- A. Type I reaction
- B. Type II reaction
- C. Type III reaction
- D. Type IV reaction
14. Non-fibrillar amyloid components include all except:
- A. Amyloid P component
- B. Apolipoprotein E
- C. Protein X
- D. Cystatin
15. Which of the following is heredo-familial form of amyloidosis?
- A. Polyneuropathic amyloidosis
- B. Cardiac amyloidosis
- C. Cerebral amyloidosis
- D. Endocrine amyloidosis
16. CD4 T cell count in crisis phase of HIV according to revised HIV/AIDS classification is:
- A. < 100/ microlitre
- B. < 200/ microlitre
- C. < 250/ microlitre
- D. < 500/ microlitre
17. Test useful for detection of HIV during window period:
- A. ELISA
- B. Western blot
- C. CD4+ cell count
- D. p24 antigen capture assay
18. Haematoxylin body represents:
A. Nuclear chromatin material
B. RNA
C. Cytosolic components
D. Cell membrane components
19. For counting of CD4 + T cells in AIDS, the following technique is often employed:
A. In situ hybridisation
B. Polymerase chain reaction
C. Flow cytometry
D. Electron microscopy
20. For karyotyping, the dividing cells are arrested by addition of colchicine in the following mitotic phase:
- A. Prophase
- B. Metaphase
- C. Anaphase
- D. Telophase
Answer Key
1) = B, 2) = A, 3) = B, 4) = A, 5) = B, 6) = B, 7) = C, 8) = B, 9) = C, 10) = C, 11) = C, 12) = B, 13) = B, 14) = D, 15) = A, 16) = B, 17) = D, 18) = A, 19) = C, 20) = C