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Immunopathology Including Amyloidosis MCQs with Answers

1. Transplantation antigens are located on portion of:

  1. A. Chromosome 1
  2. B. Chromosome 6
  3. C. Chromosome 9
  4. D. Chromosome 22

2. Class I HLA antigens are located on:

  1. A. All nucleated cells of the body
  2. B. B and T lymphocytes
  3. C. Macrophages
  4. D. Complement system

3. HIV contaminated waste products can be decontaminated by the following agents except:

  1. A. Sodium hypochlorite
  2. B. Methanol
  3. C. Formaldehyde
  4. D. Glutaraldehyde

4. CD4 bearing subpopulation of macrophages are attacked by HIV and cause the following except:
A. Cytopathic effects
B. Act as reservoir of HIV infection
C. Act as source of infection in nervous system
D. Defects in CD4+ T lymphocytes

5. In autoimmune haemolytic anaemia, the following type of immunologic tissue injury is involved:
A. Type I (anaphylactic)
B. Type II (cytotoxic)
C. Type III (immune complex)
D. Type IV (cell mediated)

6. Out of various antinuclear antibodies, pathognomonic of SLE is:
A. Antibody to single-stranded DNA
B. Antibody to double-stranded DNA
C. Antibody to histones
D. Antibody to nucleolar antigen

7. In cases of renal failure on long-term haemodialysis, there is development of following type of amyloid:
A. Amyloid light chain (AL)
B. Amyloid-associated protein (AA)
C. Amyloid b 2 microglobulin (Ab 2m)
D.b amyloid protein (Ab)

8. The most common form of amyloid in developing countries is:
A. Primary B. Secondary
C. Hereditary D. Localised

9. Cardiac amyloidosis often produces:
A. Dilated cardiomyopathy
B. Constrictive cardiomyopathy
C. Restrictive cardiomyopathy
D. Ischaemic cardiomyopathy

10. In senile cardiac amyloidosis, the biochemical form of amyloid is:

  1. A. AL
  2. B. AA
  3. C. ATTR
  4. D. Ab2M

11. In Alzheimer’s disease, cerebral plaques consist of:

  1. A. ATTR protein
  2. B. Ab2M protein
  3. C. Ab protein
  4. D. Prion protein

12. Amyloid enhancing factor (AEF) plays a significant role in:
A. Primary amyloid
B. Secondary amyloid
C. Senile cerebral amyloid
D. Haemodialysis-associated amyloid

13. Grave’s disease is a type of:

  1. A. Type I reaction
  2. B. Type II reaction
  3. C. Type III reaction
  4. D. Type IV reaction

14. Non-fibrillar amyloid components include all except:

  1. A. Amyloid P component
  2. B. Apolipoprotein E
  3. C. Protein X
  4. D. Cystatin

15. Which of the following is heredo-familial form of amyloidosis?

  1. A. Polyneuropathic amyloidosis
  2. B. Cardiac amyloidosis
  3. C. Cerebral amyloidosis
  4. D. Endocrine amyloidosis

16. CD4 T cell count in crisis phase of HIV according to revised HIV/AIDS classification is:

  1. A. < 100/ microlitre
  2. B. < 200/ microlitre
  3. C. < 250/ microlitre
  4. D. < 500/ microlitre

17. Test useful for detection of HIV during window period:

  1. A. ELISA
  2. B. Western blot
  3. C. CD4+ cell count
  4. D. p24 antigen capture assay

18. Haematoxylin body represents:
A. Nuclear chromatin material
C. Cytosolic components
D. Cell membrane components

19. For counting of CD4 + T cells in AIDS, the following technique is often employed:
A. In situ hybridisation
B. Polymerase chain reaction
C. Flow cytometry
D. Electron microscopy

20. For karyotyping, the dividing cells are arrested by addition of colchicine in the following mitotic phase:

  1. A. Prophase
  2. B. Metaphase
  3. C. Anaphase
  4. D. Telophase

Answer Key
1) = B, 2) = A, 3) = B, 4) = A, 5) = B, 6) = B, 7) = C, 8) = B, 9) = C, 10) = C, 11) = C, 12) = B, 13) = B, 14) = D, 15) = A, 16) = B, 17) = D, 18) = A, 19) = C, 20) = C