Description
Anti-Tuberculosis Drugs VI-B
• • Discuss the characteristics of anti-tubercular drugs i.e.
o Mechanism of action
o Indication
o Contraindication
• Discuss primary and secondary management of TB.
• Describe the rationale for multiple drug therapy in treatment of TB.
• Discuss appropriate nursing implication for client receiving anti- tuberculin therapy.
• Calculate the drug dosage accurately while administering oral and parental medications.
• Introduction
• Historical Background
• 1944 – Para-aminosalicylic acid (PAS)
• 1946 – Streptomycin (SM)
• 1946 – Thioacetazone
• 1952 – Isoniazid (INH)
• Replaces sanatorium as major treatment. Patients can be
treated as out-patient
• 1952 – Pyrazinamide (PZA), Combination therapy of INH and
PZA cures TB
• 1955 – Cycloserine (CS)
• The Aims of anti‐TB Treatment
• Treatment Through more than one Drug
• Anti -tuberculosis drugs
• Isoniazid
• Pharmacokinetics of Isoniazid
• Adverse effects
• Rifampicin
• Pharmacokinetics
• Adverse effects
• Ethambutol
• Pharmacokinetics
• Adverse effects
• Pyrazinamide
• Adverse effect
• Streptomycin
• Capreomycin
• Pulmonary TB
• Anti-TB therapy
• Drug resistance
• Nursing Implication
• Dosage Calculation
- Subject:- Pharmacology
- Course:- B.pharm (pharmacy),
- Semester:- 5th sem , sem :- 5
