Pharmacology II (BP602TP)
Emetics & Anti-emetics
1 The most dependable emetic used to expel ingested poisons is:
A.Intramuscular emetine
B.Oral syrup ipecacuanha
C.Intramuscular apomorphine
D.Oral bromocriptine
2 In a conscious patient of poisoning, use of an emetic is permissible in case the ingested poison is:
A.Ferrous sulfate
B.Sodium hydroxide
C. Kerosine
D.Morphine
3 The most effective antimotion sickness drug suitable for short brisk journies is:
A.Promethazine theoclate
B.Cinnarizine
C.Prochlorperazine
D.Hyoscine
4 In case of hill journey, antimotion sickness drugs are best administered at:
A.Twelve hours before commencing journey
B.One hour before commencing journey
C.Immediately after commencing journey
D.At the first feeling of motion sickness
5 Chlorpromazine and its congeners suppress vomiting of following etiologies except:
A.Motion sickness
B.Radiation sickness
C.Postanaesthetic
D.Uremic
6 Choose the phenothiazine compound which has selec- tive labyrinthine suppressant action, is used for vomiting and vertigo, but not in schizophrenia:
A.Triflupromazine
B.Prochlorperazine
C. Trifluoperazine
D.Thioridazine
7 Metoclopramide has the following actions except:
A.Increases lower esophageal sphincter tone
B.Increases tone of pyloric sphincter
C.Increases gastric peristalsis
D.Increases intestinal peristalsis
8 Metoclopramide blocks apomorphine induced vomiting, produces muscle dystonias and increases prolactin release indicates that it has:
A.Anticholinergic action
B.Antihistaminic action
C.Anti 5-HT3 action
D.Antidopaminergic action
9 Activation of the following type of receptors present on myenteric neurones by metoclopramide is primarily responsible for enhanced acetylcholine release improving gastric motility:
A.Muscarinic M1
B.Serotonergic 5-HT3
C.Serotonergic 5-HT4
D.Dopaminergic D2
10 Select the prokinetic-antiemetic drug which at rela-tively higher doses blocks both dopamine D2 as well as 5-HT3 receptors and enhances acetylcholine release from myenteric neurones:
A.Cisapride
B.Prochlorperazine
C. Metoclopramide
D.Domperidone
11 Which prokinetic drug(s) produce(s) extrapyramidal side effects:
A.Metoclopramide
B.Cisapride
C. Domperidone
D.All of the above
12 The progastrokinetic action of the following drug(s) is attenuated by atropine:
A.Domperidone
B. Metoclopramide
C.Cisapride
D.Both ‘B’ and ‘C’
13 A patient returning from dinner party meets with road accident and has to be urgently operated upon under general anaesthesia. Which drug can be injected intramuscularly to hasten his gastric emptying:
A.Methylpolysiloxane
B.Promethazine
C. Metoclopramide
D.Apomorphine
14 Select the correct statement regarding the antiemetic efficacy of the three prokinetic drugs metoclopramide, domperidone and cisapride:
A.Cisapride is the most effective
B.Metoclopramide is the most effective
C.Domperidone is the most effective
D.All three are equally efficacious
15 Which antiemetic selectively blocks levodopa induced vomiting without blocking its antiparkinsonian action:
A.Metoclopramide
B.Cisapride
C. Domperidone
D.Ondansetron
16 The following prokinetic drug has been implicated in causing serious ventricular arrhythmias, particularly in patients concurrently receiving erythromycin or ketoconazole:
A.Domperidone
B.Cisapride
C. Mosapride
D.Metoclopramide
17 Indicate the drug which does not improve lower esophageal sphincter tone or prevent gastroesopha-geal reflux, but is used as first line treatment of gastroesophageal reflux disease:
A.Sodium alginate + aluminium hydroxide gel
B. Omeprazole
C. Mosapride
D.Famotidine
18 Select the drug(s) which afford(s) relief in gastro-esophageal reflux by increasing lower esophageal sphincter tone and promoting gastric emptying, but without affecting acidity of gastric
contents:
A.Sodium alginate
B. Metoclopramide
C.Cisapride
D.Both ‘B’ and ‘C’
19 The fastest symptomatic relief as well as highest healing rates in reflux esophagitis are obtained with:
A.Prokinetic drugs
B. H2 receptor blockers
C.Proton pump inhibitors
D.Sodium alginate
20. Prokinetic drugs serve the following purpose(s) in gastroesophageal reflux disease:
A.Reduce reflux of gastric contents into esophagus
B.Promote healing of esophagitis
C.Reduce acidity of gastric contents
D.Both ‘A’ and ‘B’ are correct
21 Cisapride enhances gastrointestinal motility by:
A.Activating serotonin 5-HT4 receptor
B.Activating muscarinic M3 receptor
C.Blocking dopamine D2 receptor
D.All of the above
22 The most effective antiemetic for controlling cisplatin induced vomiting is:
A.Prochlorperazine
B.Ondansetron
C. Metoclopramide
D.Promethazine
23 Select the antiemetic that prevents activation of emetogenic afferents in the gut and their central relay in chemoreceptor trigger zone/nucleus tractus solitarious, but has no effect on gastric motility:
A.Ondansetron
B. Domperidone
C. Metoclopramide
D.Cisapride
24 Granisetron is a:
A.Second generation antihistaminic
B.Drug for peptic ulcer
C.Antiemetic for cancer chemotherapy
D.New antiarrhythmic drug
25. Ondansetron is effective in the following type(s) of vomiting:
A.Cisplatin induced
B.Radiotherapy induced
C. Postoperative
D.All of the above
26 Ondansetron blocks emetogenic impulses at the following site(s):
A.Vagal afferents in intestines
B.Nucleus tractus solitarius
C.Chemoreceptor trigger zone
D.All of the above
27 Choose the correct statement about ondansetron:
A.It is a dopamine D2 receptor antagonist
B.It suppresses postoperative nausea and vomiting
C.It is the most effective antiemetic for motion sickness
D.It is not effective by oral route
28 Cancer chemotherapy induced vomiting that is not controlled by metoclopramide alone can be suppressed by combining it with:
A.Amphetamine
B. Dexamethasone
C.Hyoscine
D.Cyclizine
29 Prolonged treatment with the following drug can promote dissolution of gallstones if the gall bladder is functional:
A.Ursodeoxycholic acid
B.Sodium taurocholate
C.Sodium glycocholate
D.Cholecystokinin
