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Gastrointestinal Drugs Anti-ulcer Agents MCQs with Answers

Pharmacology II (BP602TP)

Gastrointestinal Drugs Anti-ulcer Agents

1. Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because:
A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well
B. H2 blockers inhibit the proton pump in gastric mucosa
C.Acetylcholine and gastrin act partly by releas- ing histamine in gastric mucosa
D.Histamine, acetylcholine and gastrin all act through the phospholipase C-IP3:DAG path-way in gastric mucosa

2. For healing duodenal ulcer the usual duration of H2 blocker therapy is:
A.4 weeks
B.6 weeks
C.8 weeks
D.12 weeks

3. What is true of acid control therapy with H2 blockers:
A.It generally heals duodenal ulcers faster than gastric ulcers
B.It checks bleeding in case of bleeding peptic ulcer
C.It prevents gastroesophageal reflux
D.Both ‘A’ and ‘B’ are correct

4. In the intact animal H2 receptor antagonists poten-tiate the following action of histamine:
A.Cardiac stimulation
B.Fall in blood pressure
C.Uterine relaxation

5 Gynaecomastia can occur as a side effect of:
C. Famotidine

6. Which histamine H2 blocker has most marked inhibitory effect on microsomal cytochrome P-450 enzyme:
C. Roxatidine

7. Choose the correct statement about H2 receptor blockers:
A. They are the most efficacious drugs in inhibiting gastric acid secretion
B.They cause fastest healing of duodenal ulcers
C.They prevent stress ulcers in the stomach
D.They afford most prompt relief of ulcer pain

8. Ranitidine differs from cimetidine in the following respect:
A.It is less potent
B.It is shorter acting
C.It does not have antiandrogenic action
D.It produces more CNS side effects

9. Compared to H2 blockers, omeprazole affords the following:
A.Faster relief of ulcer pain
B.Faster healing of duodenal ulcer
C.Higher efficacy in healing reflux esophagitis
D.All of the above

10. Choose the drug which blocks basal as well as stimulated gastric acid secretion without affecting cholinergic, histaminergic or gastrin receptors:
B. Loxatidine
C. Omeprazole

11. Omeprazole exerts practically no other action except inhibition of gastric acid secretion because:
A.It transforms into the active cationic forms only in the acidic pH of the gastric juice
B.Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells
C.Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi
D.All of the above

12. The most efficacious drug for inhibiting round the clock gastric acid output is:

13. The following is true of proton pump inhibitors except:
A.They are the most effective drugs for Zolinger Ellison syndrome
B.Their prolonged use can cause atrophy of gastric mucosa
C.They inhibit growth of H. pylori in stomach
D.They have no effect on gastric motility

14. The first choice drug for nonsteroidal antiinflammatory drug associated gastric ulcer is:
B. Misoprostol

15. Select the drug which is an inhibitor of gastric mucosal proton pump:
A.Carbenoxolone sodium
C. Famotidine

16. The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin content:
A.Histamine H2 blockers
C.Proton pump inhibitors

17. The primary mechanism by which prostaglandins promote ulcer healing is:
A.Inhibition of gastric acid secretion
B.Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa
C.Increased bicarbonate secretion in gastric juice
D.Increased turnover of gastric mucosal cell

18 Choose the antiulcer drug that inhibits gastric acid secretion, stimulates gastric mucus and bicarbonate secretion and has cytoprotective action on gastric mucosa:

C. Carbenoxolone sodium
D.Colloidal bismuth subcitrate

19. The following statement is true about misoprostol:
A.It relieves peptic ulcer pain, but does not promote ulcer
B.It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding to H2 blockers
C.It produces fewer side effects than H2 blockers
D.It is the most effective drug for preventing ulcer relapse

20. The ‘acid neutralizing capacity’ of an antacid is governed by:
A.The equivalent weight of the antacid
B.The pH of 1N solution of the antacid
C.The rate at which the antacid reacts with HCl
D.Both ‘A’ and ‘C’

21. As an antacid, sodium bicarbonate has the following disadvantages except:
A.It causes acid rebound
B.In ulcer patients, it increases risk of perforation
C.It has low acid neutralizing capacity
D.It is contraindicated in hypertensives

22 The following is true of aluminium hydroxide gel except:
A.It is a weak and slowly reacting antacid
B.Its acid neutralizing capacity decreases on storage
C.It interferes with absorption of phosphate in the intestine
D.It causes loose motions as a side effect

23 Choose the correct statement about magaldrate:
A.It is a mixture of magnesium and aluminium hydroxides
B. It has a rapid as well as sustained acid neutralizing action
C. Its acid neutralizing capacity is 2 m Eq g
D.It causes systemic alkalosis

24. Antacid combinations of magnesium and aluminium salts are superior to single component preparations because:
A.They have rapid as well as sustained acid neutralizing action
B. They are less likely to affect gastric emptying
C.They are less likely to alter bowel movement
D.All of the above

25 In peptic ulcer, antacids are now primarily used for:
A.Prompt pain relief
B.Ulcer healing
C.Preventing ulcer relapse
D.Control of bleeding from the ulcer

26 Sucralfate promotes healing of duodenal ulcer by:
A.Enhancing gastric mucus and bicarbonate secretion
B.Coating the ulcer and preventing the action of acid- pepsin on ulcer base
C.Promoting regeneration of mucosa
D.Both ‘A’ and ‘B’ are correct

27 Antacids administered concurrently reduce efficacy of the following antipeptic ulcer drug:
B.Colloidal bismuth


28 The following antiulcer drug does not act by reducing the secretion of or neutralizing gastric acid:
C. Misoprostol

29 The most important drawback of sucralfate in the treatment of duodenal ulcer is:
A.Low ulcer healing efficacy
B.Poor relief of ulcer pain
C.High incidence of side effects
D.Need for taking a big tablet four times a day

30 Choose the correct statement about colloidal bismuth subcitrate:
A.It causes prolonged neutralization of gastric acid
B.It has anti-H.pylori activity
C.It relieves peptic ulcer pain promptly
D.All of the above are correct

31 Eradication of H.pylori along with gastric antisecretory drugs
affords the following benefit(s):
A.Faster relief of ulcer pain
B.Faster ulcer healing
C.Reduced chance of ulcer relapse
D.Both ‘B’ and ‘C’ are correct

32 The drugs employed for anti-H.pylori therapy include the following except:
C. Tinidazole


33 The following is true of anti-H.pylori therapy except:
A.It is indicated in all patients of peptic ulcer
B.Resistance to any single antimicrobial drug develops rapidly
C.Concurrent suppression of gastric acid enhances efficacy of the regimen
D.Colloidal bismuth directly inhibits H.pylori but has poor patient acceptability

34 The preferred regimen for preventing duodenal ulcer relapse is:
A.Maintenance antacid regimen
B.Maintenance H2 blocker regimen
C.On demand intermittent H2 blocker regimen
D.Maintenance sucralfate regimen