Class: Third Year Year Semester: Third
Subject: Formulative Pharmacy
Code : BP502T
1. Preformulation studies helps in establishing ………………… of a new drugs.
A) Physical properties
B) Kinetic rate profile
C) Chemical properties
D) All the above
2. According to BCS, class III drugs are,…………..
A) Low solubility and Low permeability drugs
B) Low solubility and High permeability drugs
C) High solubility and High permeability drugs
D) High solubility and Low permeability drugs
3. Preformulation is about ensuring
A. Stability
B. Safety
C. Efficacy
D. All of the above
4. Crystal form shows this structure
A. 3D
B. 2D
C. Short range
D. None of the above
5. In simple cubic crystal the faces are
A. All unequal
B. Two equal one unequal
C. All equal
6. Two or more molecules are hydrogen bonded to each other are called
A. Crystals
B. Cocrystals
C. Polymorph
D. All of the above
7. DSC is ……………….
A. Differential scanning calorimetry
B. Differential scttering calorimetry
C. Digital scanning calorimetry
D. None of the above
8. X ray diffraction pattern indicate
A. Solubility
B. Crystallinity
C. Functional groups
D. Permeability
9. SEM can analyze ……..
A. Shape & Size
B. Crystallinity & Solubility
C. Complexation
D. Flow property
10. Bragg’s law define the
A. Shape
B. Solubility
C. Diffraction
D. All of the above
11. Crystal form shows
A. Short duration of action
B. Rapid duration of action
C. Short onset of action
D. Long duration of action
12.The ability of a substance to exist as two or more crystalline phases with different arrangements of molecules in crystal lattice is
A. Cocrystal
B. Crystal
C. Polymorphism
D. None of the above
13. Polymorphs differ in
A. Physical properties
B. Chemical Properties
C. A & B both
D. None of the above
14. Hydrates and colvates are called
A. Polymorph
B. Pseudopolymorph
C. Cocrystals
D. None of the above
15. Coulter Counter can analyze
A. Size distribution
B. Crystallinity & Solubility
C. Number of functional groups
D. Flow property
16. Single-station tablet press is also called as
a) Eccentric press
b) Single punch tablet press
c) Both (a) and (b)
d) None of the above
17. Tablet coating is done to………….
a) Mask the unpleasant taste and odour
b) Improve patient acceptability
c) Provide control drug release
d) All of the above
18. Sugar coating increases the tablet weight by…………..
a) 50 – 100%
b) 5-10%
c) 50%
d) 10 – 15%
19. ………………is an example of enteric film former.
a) Cellulose acetate phthalate
b) Hydroxypropyl methyl cellulose
c) Polyethylene glycol
d) Ethylcellulose
20. Rate of sedimentation is high in ………………….
a) Deflocculated suspensions
b) Flocculated suspensions
c) Both (a) and (b)
d) None of the above
21. Emulsifiers act as detergents, when the HLB value is
a) < 10
b) 10
c) < 15
d) > 15
22. …………….are hydroalcoholic solutions of drugs with low water solubility.
a) Linctuses
b) Elixirs
c)Draughts
d) Douches
23. Which of the following can be formulated into hard gelatin capsules?
a) Pellets
b) Powders
c) Granules
d) All of the above
24. The ratio of gelatin to water in capsule shell is
a) 1:1
b) 0.7:1
c) 1: 1.3
d) 0.7:1.3
25. Empty hard gelatin capsules for human use are available in …………different sizes.
a)5
b) 8
C) 3
d) 6
26. Which of the following is not a soft gelatin capsulation process?
a) Vacuum filling
b) Plate process
c) Rotary die process
d) Reciprocating die process
27. Which of the following is the smallest size hard gelatin capsule?
a) 000
b) 00
c) 0
d) None of the above
28. Which among the following is not a screw-feed extruder?
a) Dome extruder
b) Radial feed extruder
c) Rotary gear extruder
d) End plate screw feed extruder
29. ……………..drugs can be processed in RAM extruder.
a) Thermolabile
b) Thermostable
c) Both (a) and (b)
d) None of the above
30. Radial Extruder belongs to ………………….
a) AxiaVend plate screw feed extruders
b) Gravity/roll feed extruders
c) Piston feed extruders/RAM extruders
d) None of the above
31. …………….density extrudate is produced by gravity feed extruder.
a) Higher
b) Lower
c) Both (a) and (b)
d) None of the above
32. Extruders and spheronizers are used to produce,
a) Controlled released pellets for encapsulation
b) Sustained release pellets
c) Multi-particulate systems
d) All of the above
33. ………………….are applied directly to the affected area.
a) Eye drops
b) Eye gels
c) Eye ointments
d) Eye suspensions
34. Eye drops are used in which of the following disorders?
a) Cataract surgery
b) Glaucoma
c) Conjunctivitis
d) All the above
35. Which of the following ophthalmic preparations exhibit higher bioavailability?
a) Eye drops
b) Eye gels
c) Eye ointments
d) Eye suspensions
36. Intracraneal injections are sterile solutions of drugs meant to be injected in
a) Cornea
b) Sclera
c) Vitreous cavity
d) Posterior chamber of eye
37. ………………..facilitates the insertion of the lens comfortably into the eye.
a) Viscosifier
b) Tonicity adjuster
c) Wetting solution
d) Buffering agent
38. Filtration sterilization is suitable for…………..
a) Ophthalmic and parenteral solutions
b) Antibiotic solutions
c) Blood components
d) All of the above
39. ……………….are the most commonly used eye lotions.
a) Sodium chloride eye lotion
b) Sodium bicarbonate eye lotion
c) Both (a) and (b)
d) None of the above
40.…….are used to soothen, refresh and remove redness of eye due to minor irritation.
a) Cycloplegics
b) Artificial tears
c) Decongestants
d) None of the above
41. ……..helps in improving or changing the appearance of the body and also masks the odour
a) Accessories
b) Cosmetics
c) Clothes
d) None of the above
42. ………are used for the purpose of removing make-up, surface grime and secretions of
the neck respectively.
a) Vanishing creams
b) Hand creams
c) Cleansing and cold creams
d) Body creams
43. ……………..are semisolid emulsions containing mixtures of oil and water.
a) Creams
b) Lotions
c) Powders
d) Rouges
44. Whitening agent used in the formulation of tooth paste is ………………..
a) Calcium carbonate
b) Titanium dioxide
c) Chlorhexidine
d) Methyl paraben
45. ……………..helps in expelling the contents from the aerosol container.
a)Valves
b) Actuators
c) Ferrule
d) Spring
46. Steroids and antibiotics are formulated and dispensed by………… foam systems.
a) Non-aqueous stable
b) Stable-aqueous
c) Aqueous stable
d) Thermal
47. ………………helps in dispensing active ingredient in the form of mist or spray.
a) Foam system
b) Aqueous stable system
c) Aquasol system
d) Intranasal system
48. Which of the following is similar to threaded screw-on closures?
a) Lug closure
b) Press-on closure
c) Plug- type closures
d) Roll-on closures
48. The process of dry granulation involves initial conversion of powder tablet blend into …………………. or …………….. .
a) Slug, Compact masses
b) Damp, coherent mass
c) Hard, compressed mass
d) smooth, shining
49. Which of the following is the smallest size hard gelatin capsule?
a) 5
b) 00
c) 000
d) None of the above
50. Angle of repose is given by
a) ø =tan -1 (H/R)
b) ø =tan (H/R)
c) ø =tan -1(R/H)
d) ø =tan (R/H)
51. ………………………….. studies are carried out prior to the actual formulation of the drug.
a) Preformulation
b) Bioavailability
c) Clinical
d) Bioequivalence
52. Preformulation studies helps in establishing ……………………… of a new drugs.
a) Physical properties
b) Kinetic rate profile
c) Chemical properties
d) All the above
53. According to BCS, class II drugs are,
a) Low solubility and Low permeability drugs
b) Low solubility and High permeability drugs
c) High solubility and High permeability drugs
d) High solubility and Low permeability drugs
54. According to BCS, class III drugs are,
a) Low solubility and Low permeability drugs
b) Low solubility and High permeability drugs
c) High solubility and High permeability drugs
d) High solubility and Low permeability drugs
55. According to BCS, class I drugs are,
a) Low solubility and Low permeability drugs
b) Low solubility and High permeability drugs
c) High solubility and High permeability drugs
d) High solubility and Low permeability drugs
56. ……………….. and ………………. Collectively gives a measure of the tablet
strength.
a) Friability, Hardness
b) Dimensions, Hardness
c) Friability, Dissolution
d) Dissolution, Hardness
57. The biopharmaceutics classification system is based on ………………….. of a drug
substances.
a) Solubility
b) Permeability
c) Dissolution rate
d) All the above
58. Rate of sedimentation is high in ………………………. .
a) Deflocculated suspensions
b) Flocculated suspensions
c) Both (a) and (b)
d) None the above
59. Type I glass is …………….
A) Soda lime
B) Treated soda lime
C) Borosilicate glass
D) None of the above
60. Higher HLB values (9-12) of emulsifying agents produce …. Type of emulsion.
A) Oil in Water
B) Water in Oil
C) Both A and B
D) None of the above
61. In deflocculated suspensions, …………………… of particles is difficult.
A) Redispersion
B) stabilization
C) Both (a) and (b)
D) None the above
62. ………….. studies are carried out prior to the actual formulation of the drug.
A) Bioequivalence
B) Bioavailability
C) Clinical
D) Preformulation
