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GTU 2020 – 2021 Question paper BPharmacy (sem:- 6) All subject

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  • GUJARAT TECHNOLOGICAL UNIVERSITY
    Bachelor of Pharmacy
    Subject Code: BP501TT
    SEMESTER: 6 sem 6 semester 6
  • B.pharm sem 6 all subject Questions paper 2020 summer and winter, sem 6 question paper gtu, gtu previous year question papers with solutions, gtu paper solution 6th sem pdf, all subject Questions paper first sem b.pharm, BPharmacy all subject Questions paper sem 6,Gtu sem 6 Question paper, 2020 Questions paper sem 6, Sem 6 2020 Question paper all subject, Sem 6 gtu old Question paper for pharmacy
  • Seat No.: _____                                             Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                 B.PHARM - SEMESTER– 6 EXAMINATION – SUMMER -2020
    
    Subject Code: BP601TP                                                   Date:26-10-2020
    Subject Name: Medicinal Chemistry III
    Time: 10:30 AM TO 1:30 PM                                               Total Marks: 80
    Instructions:
        1. Attempt any five questions.
        2. Make suitable assumptions wherever necessary.
        3. All question carry marks.
    
     Q.1   (a)    Discuss various approaches used in drug design.                             6
           (b)    Write brief note on Combinatorial Chemistry.                                5
           (c)    What is QSAR? Give detailed note on Hansch model.                           5
    
     Q.2   (a)    Classify Antimalarial Agents with examples and structures.                  6
           (b)    Discuss SAR of Quinolines.                                                  5
           (c)    Write note on concept and applications of Prodrugs.                         5
    
     Q.3   (a)    Differentiate terms with examples: Bacteriostatics & Bactericidals. Write   6
                  SAR of Cephalosporins.
           (b)    Write short note on Chemistry of Aminoglycosides.                           5
           (c)    Discuss Chemistry and advantages of Semisynthetic Penicilins.               5
    
     Q.4   (a)    Comment on: “Tetracyclines should not be taken with milk”. Write SAR of     6
                  Tetracyclines.
           (b)    Give synthesis of Chloramphenicol and Chloroquine                           5
           (c)    Write short note on Macrolides.                                             5
    
     Q.5   (a)    What is MDR TB & XDR TB? Write a note on first-line Anti TB drugs.          6
           (b)    Give synthesis of Isoniazid and Ciprofloxacin.                              5
           (c)    Write short note on Quinolones.                                             5
    
     Q.6   (a)    Explain in brief about Azoles as Antifungal Agents. Write synthesis of      6
                  Tolnaftate.
           (b)    Explain SAR of Sulphonamides. Write synthesis of Sulphamethoxazole.         5
           (c)    Give the IUPAC name, synthesis and mechanism of Albendazole OR              5
                  Mebendazole, an anthelmintic agent.
    
     Q.7   (a)    Write brief account on Antiamoebic Agents. Give synthesis of                6
                  Metronidazole.
           (b)    Give synthesis of Trimethoprim and Nitrofurantoin                           5
           (c)    Write detailed note on Antiviral Agents.                                    5
                                       *********************
    Seat No.: _____                                               Enrolment No. _____________
    
                   GUJARAT TECHNOLOGICAL UNIVERSITY
                      B.Ph. – SEMESTER VI – EXAMINATION – WINTER -2020
    
    Subject Code: BP601TP                                                    Date: 02/01/2021
    Subject Name: Medicinal Chemistry III
    Time: 02:00PM TO 04:00PM                                                     Total Marks: 54
    Instructions:
        1. Attempt any THREE questions from Q-1 to Q-6.
        2. Q.7 is compulsory to attempt.
        3. Make suitable assumptions wherever necessary.
        4. Figures to the right indicate full marks.
    
    Q.1    (a)   Classify cephalosporin. Write a note on monobactam.                               06
           (b)   Define and classify prodrug with suitable examples.                               05
           (c)   What is QSAR? Write a note on Hansch analysis.                                    05
    Q.2    (a)   What is combinatorial chemistry? Explain different methodologies used for         06
                 synthesis.
           (b)   Classify sulphonamides based on chemical structures. Outline synthesis of         05
                 sulphamethoxazole.
           (c)   Explain SAR of Sulphonamides.                                                     05
    Q.3    (a)   Classify antitubercular agent. Give synthesis of Isoniazid.                       06
           (b)   Write short notes on computer aided drug design.                                  05
           (c)   Describe SAR of quinolines. Explain mechanism of chloroquine.                     05
    Q.4    (a)     i. Life cycle of malarial parasite                                              06
                  ii. Macrolide antibiotic
           (b)   Write a note on applications of prodrug.                                          05
           (c)   Write IUPAC name and synthesis of the following drugs :                           05
                     (i)    Miconazole          (ii) Mebendazole
    Q.5    (a)   Give brief note on antiviral agents.                                              06
           (b)   Write the chemical degradation of penicillin with structures.                     05
           (c)   Explain SAR of quinolones as antibacterial agent.                                 05
    Q. 6   (a)   Classify and explain mechanism of action of azole antifungal agents. Draw         06
                 structure of one drug from each class of it.
           (b)   Write uses and synthesis of the following drugs :                                 05
                 (i) Ciprofloxacin          (ii) Acyclovir
           (c)   Draw general structure of tetracycline antibiotics. Explain mechanism of action   05
                 and side effects of it.
    Q.7    (a)      i.   What is tissue amoebicide and luminal amoebicid? Give examples.           06
                   ii.   Outline the synthesis of metronidazole.
                  iii.   What is anthelmintic? Explain mechanism of benzimidazole as
                         anthelmintic.
                                                           OR
           (a)   Write a short note on aminoglycoside antibiotics.                                 06
                                                           OR
           (a)   Give IUPAC name and synthesis of the following drugs :                            06
                 (i) Chloroquine           (ii) Chloramphenicol
    
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    Seat No.: _____                                                  Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                  B.PHARM - SEMESTER– 6 EXAMINATION – SUMMER -2020
    
    Subject Code:BP602TP                                                     Date: 27-10-2020
    Subject Name: PHARMACOLOGY III
    Time: 10:30 AM TO 1:30 PM                                                   Total Marks: 80
    Instructions:
       1. Attempt any five questions.
       2. Make suitable assumptions wherever necessary.
       3. Figures to the right indicate full marks.
    
    Q.1    (a)   Write mechanism of action, side effects of 1) Nelfinavir 2) Isoniazid            06
                 3) Tamoxifen.
           (b)   What is HAART? Write a note on drugs used in treatment of HIV infection.         05
           (c)   Classify antifungal agents & write a note on azoles as antifungal agent.         05
    Q.2    (a)   Classify third generation Cephalosporin’s & write its MOA and therapeutic        06
                 actions.
           (b)   What is drug resistance? Write different mechanisms of transfer of resistance    05
                 genes within and among bacteria.
           (c)   Explain the following terms : i)Acute toxicity ii) Superinfection iii) Jarish    05
                 Herxheimer reaction iv) Cross resistance v) Kernicterus
    Q.3    (a)   Classify types of Leprosy. Write detail pharmacology of Dapsone.                 06
           (b)   Explain in brief tissue schizontocidal agents.                                   05
           (c)   Explain in detail MDR-TB and write a note on DOTS.                               05
    Q.4    (a)   Classify Laxatives. Explain Osmotic purgatives.                                  06
           (b)   Write MOA of following drugs: i) Metoclopramide ii) Mesalazine iii)              05
                 Etofamide iv) Foscarnet v) Doxorubicin
           (c)   Write a note on anthelmintics.                                                   05
    Q.5    (a)   Write a note immunostimulants.                                                   06
           (b)   Discuss the role of antimetabolites in treatment of cancer.                      05
           (c)   Discuss treatment and management of diarrhea with emphasis on ORT.               05
    Q. 6   (a)   Write in detail the drugs used in treatment of Syphilis and Gonorrhea.           06
           (b)   Classify the drugs used in treatment of UTI. Write a note on Quinolones.         05
           (c)   Explain in brief the mechanism of biological agents as immunosuppressants.       05
    Q.7    (a)   Explain the use of Leukotriene antagonists in treatment of asthma.               06
           (b)   Define cough. Differentiate between Expectorants and Antitussive agents          05
           (c)   Explain the role of chronology in occurrence of various diseases.                05
    
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    Seat No.: _____                                              Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                  B.Pharm. - SEMESTER–VI • EXAMINATION – WINTER -2020
    
    Subject Code: BP602TP                                                    Date: 05/01/2021
    Subject Name: PHARMACOLOGY III
    Time: 02:00PM TO 04:00PM                                                  Total Marks: 54
    Instructions:
        1. Attempt any THREE questions from Q-1 to Q-6.
        2. Q.7 is compulsory to attempt.
        3. Make suitable assumptions wherever necessary.
        4. Figures to the right indicate full marks.
    
    Q.1    (a)   Classify anti asthmatic drugs. Describe role of sympathomimetics in the             06
                 treatment of asthma.
           (b)   Explain drug therapy for diarrhea.                                                  05
           (c)   Write a note on antitussives.                                                       05
    Q.2    (a)   Classify semi synthetic penicillins. Write antibacterial spectrum and therapeutic   06
                 uses of amoxycillin.
           (b)   Write a note on proton pump inhibitors.                                             05
           (c)   Write in detail about systemic antifungal agents.                                   05
    Q.3    (a)   Classify anticancer agents. Discuss anti metabolites in detail.                     06
           (b)   Describe the characteristics and mechanism of action of aminoglycosides.            05
           (c)   Describe mechanism of action and adverse effects of chloramphenicol.                05
    Q.4    (a)   Classify immunosupressants. Describe pharmacology of ciclosporin.                   06
           (b)   Write a note on anthelmintics.                                                      05
           (c)   Define following term: 1) Teratogenicity 2) Chronobiology 3) Sub acute toxicity     05
                 4) Antibiotics 5) Drug resistance
    Q.5    (a)   What is DOTS? Discuss the management of tuberculosis with special emphasis          06
                 on Isoniazid.
           (b)   Classify anti-malarial drugs. Write adverse effects of chloroquine.                 05
           (c)   Write a note on sexually transmitted diseases.                                      05
    Q. 6   (a)   Classify antiviral drugs. Describe pharmacology of acyclovir.                       06
           (b)   Discuss signs-symptoms and complications of various urinary tract infections.       05
           (c)   Write mechanism of action and therapeutic uses of fluoroquinolones.                 05
    Q.7    (a)   Classify sulphonamides and explain its mechanism of action and adverse effects.     06
                                                       OR
           (a)   Classify antiemetic drugs. Explain prokinetic drugs.                                06
                                                       OR
           (a)   Discuss symptoms and management of organophosphorus poisoning.                      06
    
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    Seat No.: _____                                            Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                  B.Pharm - SEMESTER–6 • EXAMINATION – SUMMER -2020
    
    Subject Code: BP603TP                                                 Date: 28-10-2020
    Subject Name: HERBAL DRUG TECHNOLOGY
    Time: : 10:30 AM TO 1:30 PM                                            Total Marks: 80
    Instructions:
        1. Attempt any five questions.
        2. Make suitable assumptions wherever necessary.
        3. Figures to the right indicate full marks.
    
    Q.1   (a)   Define Herbal Medicine. Mention in detail about various sources of Herbs.    06
          (b)   Write about Good Agricultural Practices (GAP) in cultivation of medicinal 05
                plants briefly.
          (c)   What is Pest? Give various types of Pesticides. Explain in detail about Bio- 05
                insecticides.
    Q.2   (a)   Explain Alternative system of Medicine. Write in detail about Tridosha and 06
                PanchTatva theory involved in Ayurveda system of medicine.
          (b)   Define Aristhas and Asawas. Mention general evaluation methods for Aristhas 05
                and Asawas.
          (c)   Define Neutraceutticals. Mention benefits of Nutraceuticals in various CVS 05
                disorders.
    Q.3   (a)   Mention the role of Fenugreek herb and Spirulina as Health Food.           06
          (b)   Write about Herbal-Drug interaction. Explain in detail one example each of 05
                Herb-drug and herb-food interaction.
          (c)   Write in detail about role of Black Pepper as Bioavailability Enhancer.    05
    Q.4   (a)   Compare between conventional herbal formulations and novel herbal dosage 06
                forms. Mention in detail about Phytosomes.
          (b)   Explain in detail about ICH guidelines for the evaluation of herbal drugs and 05
                their stability testing.
          (c)   Define any two: (i) Patent (ii) Biopiracy (iii) IPR                           05
    Q.5   (a)   Explain in detail about patenting aspects of Traditional Knowledge giving 06
                example of Neem.
          (b)   Explain term AST DTAB and ASU DCC. Explain in detail about Schedule Z of 05
                Drugs and Cosmetics Act for ASU drugs.
          (c)   Write about present scope and future prospects of Herbal Drug Industry.   05
    Q. 6 (a)    Give a brief account of Plant based Industries and various institutions involved 06
                in work on medicinal and aromatic plants in India.
          (b)   Write about Components and Objectives of Good Manufacturing Practices 05
                (GMP) for Ayurvedic medicines.
          (c)   Mention about Infrastructural requirements for manufacturing unit as per 05
                Schedule-T.
    Q.7   (a)   How the documentation and records are maintained and Standard Operating 06
                Procedures are followed for Herbal drug industry
          (b)   Explain about Farmer’s right and Breeder’s right.                       05
          (c)   Write a short note on Herbal excipients.                                05
    
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    Seat No.: _____                                               Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                      B.Ph. - SEMESTER–VI • EXAMINATION – WINTER -2020
    
    Subject Code:BP603TP                                                       Date:07/01/2021
    Subject Name: HERBAL DRUG TECHNOLOGY
    Time: 02:00PM TO 04:00PM                                                   Total Marks: 54
    Instructions:
        1. Attempt any THREE questions from Q-1 to Q-6.
        2. Q.7 is compulsory to attempt.
        3. Make suitable assumptions wherever necessary.
        4. Figures to the right indicate full marks.
    
    Q.1    (a)   What is churna? Describe in detail method of preparation of churna. Describe         06
                 general procedure for standardization of churna as per Ayurvedic
                 Pharmacopoeia of India. Describe advantages and disadvantages of churna as a
                 formulation.
           (b)   Discuss history of herbs as source of drugs and drug discovery.                      05
           (c)   Discuss the different methods used for the pest control. Write essential of a good   05
                 pesticides.
    Q.2    (a)   What is Bhasma? Describe in detail method of preparation of Bhasma. Describe         06
                 quality control parameters for Bhasma. In which condition Bhasma is required to
                 be prescribed?
           (b)   What is gutika? Discuss standardization parameters of the same.                      05
           (c)   Name different traditional systems of medicine. Describe holistic concept of drug    05
                 administration in these systems.
    Q.3    (a)   Name different herbs and their active constitute which are useful as                 06
                 hepatoprotective or hypolipidemic.
           (b)   Define and classify the Nutraceuticals.                                              05
           (c)   Discuss the drug –food interaction with suitable examples.                           05
    Q.4    (a)   Define and classify the herbal cosmetics. Write in details pharmacognosy of any      06
                 two plants used for skin cosmetics.
           (b)   Enlist various cosmetics for hairs. Explain about herbal shampoos in detail.         05
           (c)   Enlist various herbal excipients and describe in detail about flavours and           05
                 perfumes.
    Q.5    (a)   Enlist various herbal formulations available in market and explain in detail about   06
                 herbal syrup.
           (b)   Elaborate on ICH guidelines for safety monitoring of natural products.               05
           (c)   Enlist various government institutions / industries involved in work of medicinal    05
                 plants in India and write a note on any five Government institutions / industries.
    Q. 6   (a)   Write a note on WHO guidelines in quality assignment of herbal drugs.                06
           (b)   Discuss about requirement of infrastructure, staff and equipments for herbal drug    05
                 industry.
           (c)   Write a note on patenting aspects of Traditional Knowledge and Natural Products      05
                 with reference to turmeric.
    Q.7    (a)   Define the term – Patent, Bio prospecting and Bio piracy                             06
                                                       OR
           (a)   Give the detailed note on plant sweetening agents.                                   06
                                                       OR
           (a)   Explain in detail about herbal phytosomes.                                           06
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    Seat No.: _____                                        Enrolment No. _____________
    
                GUJARAT TECHNOLOGICAL UNIVERSITY
               B.PHARM - SEMESTER– 6 EXAMINATION – SUMMER -2020
    
    Subject Code: BP604TT                                Date:29-10-2020
    Subject Name: Biopharmaceutics and Pharmacokintetics
    Time: 10:30 AM TO 1:30 PM                            Total Marks: 80
    Instructions:
        1. Attempt any five questions.
        2. Make suitable assumptions wherever necessary.
        3. Figures to the right indicate full marks.
    Seat No.: _____                                                   Enrolment No. _____________
    
                   GUJARAT TECHNOLOGICAL UNIVERSITY
                   B.Pharm - SEMESTER–VI • EXAMINATION – WINTER -2020
    
    Subject Code: BP604TT                               Date: 11/01/2021
    Subject Name: Biopharmaceutics And Pharmacokinetics
    Time: 2:00 PM TO 4:00 PM                            Total Marks: 54
    Instructions:
        1. Attempt any THREE questions from Q-1 to Q-6.
        2. Q.7 is compulsory to attempt.
        3. Make suitable assumptions wherever necessary.
        4. Figures to the right indicate full marks.
    
    Q.1               Answer the following questions. (1 mark each)                                    16
           I)         Discuss the mechanism of intracellular transport.
           II)        Differentiate pinocytosis and phagocytosis.
           III)       Define apparent volume of distribution.
           IV)        What do you mean by renal clearance?
           V)         How many types of compartment models are there? Name them.
           VI)        Draw a schematic diagram of three compartment open model, extra-vascular
                      administration.
           VII)       What is the meaning of the term open in a compartment model?
           VIII)      What is a flip-flop phenomenon?
           IX)        Define extraction ratio.
           X)         If steady-state plasma concentration is not directly proportional to dose then
                      it detects non-linearity in pharmacokinetics. State whether the statement is
                      true or false.
           XI)        What is pharmaceutical equivalence?
           XII)       How is dissolution of a drug different from its solubility parameter?
           XIII)      Explain IVIVC
           XIV)       What is the difference between relative and absolute bioavailability?
           XV)        How AUC is calculated by trapezoidal rule?
           XVI)       Which law governs the passive diffusion process of absorption?
    
    Q.2      (a)      Write short note on carrier mediated transport mechanism of drug absorption      06
             (b)      Discuss physicochemical factors of drug substance affecting its GI               05
                      absorption.
             (c)      Explain physiological barriers to drug distribution in body.                     05
    Q.3      (a)      Explain the processes involved in the urinary excretion of drug with a           06
                      schematic diagram.
             (b)      Explain plasma-level time curve along with its pharmacokinetic parameters.       05
             (c)      Explain the concept of loading dose and maintenance dose.                        05
    Q.4      (a)      Enlist methods to determine the Ke value from urinary excretion data and         06
                      discuss any one in detail.
             (b)      Discuss applications of pharmacokinetic models.                                  05
             (c)      Write a note on PBPK models.                                                     05
    Q.5      (a)      Discuss Michaelis-Menten Equation.                                               06
             (b)      What are the assumptions made from multi-compartment model?                      05
             (c)      List out the causes of non-linearity in pharmacokinetics and discuss any one     05
                      cause in detail.
    Q. 6   (a)   Enumerate different methods to improve the dissolution rate of poorly       06
                 soluble drug. Discuss any one in detail.
           (b)   Describe different dissolution apparatus according to USP                   05
           (c)   Explain Latin Square Design for bioequivalence study.                       05
    Q.7    (a)   Discuss Wagner-Nelson method for estimation of Ka.                          06
                                                       OR
           (a)   Differentiate between plasma-protein drug binding and tissue-drug binding   06
                                                       OR
           (a)   Enlist different non-renal routes of drug excretion with example of drug    06
                 excreted through each route.
    
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    Seat No.: _____                                              Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                  B.PHARM - SEMESTER– 6 EXAMINATION – SUMMER -2020
    
    Subject Code: BP605TP                                                    Date: 02-11-2020
    Subject Name: Industrial Pharmacy – I
    Time: 10:30 AM TO 1:30 PM                                                 Total Marks: 80
    Instructions:
        1. Attempt any five questions.
        2. Make suitable assumptions wherever necessary.
        3. Figures to the right indicate full marks.
    
    Q.1    (a)   Define Preformulation studies. Explain steps involved in Preformulation studies.    06
           (b)   Describe in detail quality control for pharmaceutical aerosol products.             05
           (c)   Write a detail note on: 1. Parenteral suspension 2. Cryoprotectants                 05
    Q.2    (a)   What are pyrogens? Explain the sources of pyrogens in parenterals. Discuss          06
                 principle and method of LAL test.
           (b)   What are sunscreen preparations? Discuss their formulation and evaluation in        05
                 brief.
           (c)   Write a brief note on stability aspects of packing.                                 05
    Q.3    (a)   Comment: Sedimentation rate of flocculated suspensions is faster than               06
                 deflocculated suspensions. Differentiate flocculated and deflocculated
                 suspension.
           (b)   Discuss defects observed in tablet compression process.                             05
           (c)   Explain quality control tests of gelatin.                                           05
    Q.4    (a)   Enlist various container uses for Aerosol. Explain various types of actuator and    06
                 valve used in aerosol.
           (b)   Discuss in brief Pharmacopoeial tests for tablet.                                   05
           (c)   Discuss remedies to overcome degradation due to hydrolysis and oxidation in         05
                 pharmaceutical dosage form.
    Q.5    (a)   What are various instabilities of emulsions? Discuss them with their causes and     06
                 precautions to avoid them
           (b)   Explain BCS classification of Drugs and its significance in Preformulation          05
                 studies with suitable examples.
           (c)   Write in brief note on formulation of ophthalmic dosage form.                       05
    Q. 6   (a)   Classify cosmetics. Write short note on formulation, manufacturing and              06
                 evaluation of shampoos
           (b)   Discuss different film coating defects.                                             05
           (c)   Write a note on excipients and additives used in the capsule formulation            05
    Q.7    (a)   Describe different types of glass as a packaging material for parenteral. Explain   06
                 water attack test.
           (b)   What is Pelletization? Discuss any one pelletization technique.                     05
           (c)   Write a detailed note on storage and purity of W.F.I.                               05
    
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    Seat No.: _____                                                Enrolment No. _____________
    
                  GUJARAT TECHNOLOGICAL UNIVERSITY
                      B.Pharm - SEMESTER–VI EXAMINATION – WINTER -20
    
    Subject Code:BP605TP                                                       Date: 13/01/2021
    Subject Name: Industrial Pharmacy-I
    Time: 2:00 PM TO 4:00 PM                                                   Total Marks: 54
    Instructions:
        1. Attempt any THREE questions from Q-1 to Q-6.
        2. Q.7 is compulsory to attempt.
        3. Make suitable assumptions wherever necessary.
        4. Figures to the right indicate full marks.
    
    Q.1    (a)   Define preformulation. Write a note on physicochemical properties related to          06
                 solubility study in preformulation..
           (b)   Write a note on Polymorphism giving examples.                                         05
           (c)   Discuss in brief the evaluation test for suspensions.                                 05
    Q.2    (a)   Explain the criteria for the quality of air in an aseptic area. How is the quality    06
                 of air controlled in an aseptic area?
           (b)   What are pyrogens? Explain the sources of pyrogens in parenterals. Explain the        05
                 principle of LAL test for pyrogen testing.
           (c)   Explain preparation and storage of W.F.I.                                             05
    Q.3    (a)   Describe the in situ gelling system in ophthalmic drug delivery system.               06
           (b)   Define emulsions. Give types of emulsions. Write pharmaceutical applications          05
                 of emulsions.
           (c)   Discuss in brief the additives used in liquid dosage forms                            05
    Q.4    (a)   Discuss the compression related problem in tablet and give suitable suggestion        06
                 to overcome it.
           (b)   What is roller compactor? Draw label diagram, discuss its working and process         05
                 variable affecting on its performance
           (c)   Give the reasons for enteric coating of tablet. Enlist enteric and non enteric film   05
                 former materials. Write note on plasticizer.
    Q.5    (a)   Describe the Rotary die process for manufacturing of soft gelatin capsule.            06
           (b)   Explain size of capsules and write a note on problem and remedies in capsules.        05
           (c)   Discuss the powder glass test and water attack test for packaging in                  05
                 Pharmaceuticals.
    Q. 6   (a)   What is Pelletization? Discuss factors affecting pellet properties.                   06
           (b)   Write a note on Melt Extrusion technology                                             05
           (c)   Define: Pharmaceutical aerosols. Explain the role of propellants in an aerosol        05
                 system. Classify propellants and describe liquefied gas propellants in brief.
    Q.7    (a)   Classify filling methods for aerosols. Describe the manufacturing of aerosols by      06
                 cold filling and pressure filling method.
                                                        OR
           (a)   Differentiate between vanishing and cold cream with formulation significant           06
                                                        OR
           (a)   What is SPF in sunscreen .How to calculate it                                         06
    
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