HUMAN TERATOGENIC DRUGS
• Thalidomide – phocomelia , multiple defects of internal organs
• Anticancer drugs (methotrexate) – Cleft palate, hydrocephalus, multiple defects, foetal death
• Androgens – Virilization , limb , esophageal , cardiac defects
• Progestins – Virilization of female foetus
• Stilboestrol – Vaginal carcinoma in teenage female offspring
• Tetracyclines – Discolored and deformed teeth, retarded bone growth
• Warfarin – Depressed nose, eye and hand defects, growth retardation
• Phenytoin – Hypoplastic phalanges, cleft lip/ palate, microcephaly
• Phenobarbital – Various malformations
• Carbamazepine – Neural tube defects, assorted abnormalities
• Valproate sodium – Spina bifida and other neural tube defects, heart and limb abnormalities
