MEDICINAL CHEMISTRY
Q.1 resorcinol is treated with p-toludine, the resulting product when reacted with 2-chloro Methyl Δ2-imidazoline hydrochloride gave the product A. What is structure of A?
- a) Phentolamine
- b) Pheoxybenzamine
- c) Tolazaline
- d) Naphazoline
Q.2 Dienoesterol is synthesized from
Q.3 one of these statins is synthetic that inhibits HMG-CoA Reductase and has heptanoic Acid side chain.
- a) Pravastatin
- b) Mevastatin
- c) Atorvastatin
- d) Lovastatin
Q.4 A drug which is used in Cysticercosis and synthesize from m-chloro salicylic acid and 4- chloroaniline in the presence of pyridine and phenyl chloride at temp 1250C.
- a) Nikethimide
- b) Niclosamide
- c) pyrantel
- d) niridazole
Q.5 Cis-1-Acetyl-4-[4-[[2-(2, 4-dichlorophenyl)-2-(1H Imidazole-1-yl methyl)-1, dioxalan4yl] methoxy] phenyl] piperazine is
- a) Ketoconzole
- b) Itraconazole
- c) Fluconazole
- d) Terconazole
Q.6. what is the IUPAC name of Flurandrenolone
a) 6α-Fluoro 11β, 17, 21-trihydroxy-pregna-1, 4-diene 3, 20 Dione
b) 6α-methyl 9-fluoro 11β, 17, 21-trihydroxy-pregna-1, 4-diene 3, 20 Dione
c) 6α, 9-difluoro 11β, 16β, 17, 21-tetrahydroxy-pregna-1, 4-diene 3, 20 Dione
d) 6α fluoro 11β,16α,17,21-tetrahydroxy-pregna-1,4-diene 3,20 dione
Q.7 what type of drug interaction between Antacid & H2-Antagonists with ketaconazole?
- a) Inhibit absorption
- b) increase absorption
- c) increase metabolism
- d) inhibit metabolism
Q.8 Probencid is used in gout increase bioavailability of penicillin by
- a) Inhibiting metabolism
- b) inhibiting renal excretion
- c) increasing metabolism
- d) none
Q.9 Pheniramine malate is an antihistaminic agent belongs to the class
- a) Ethylene diamine derivative
- b) Cyclic basic class analogue
- c) Amino alkyl ether analogue
- d) none of these
Q.10 Promazine contains side chain
- a) –CH2-CH2-NH-CH3
- b) –CH2-CH2-CH2-N (CH3)2
- c) –CH2-CH2 (CH3) NH-CH3
- d) –CH2-CH (CH3)-CH2-N (CH3)2
Q.11 All of the following drugs are sugar nucleoside except
- a) Didnosine
- b) Zalcitabine
- c) lamivudine
- d) Stavudine
Q.12 when 2,3-dichlorophenoxy acid is treated with butyryl chloride in the presence of AlCl3 and the intermediate is further reacted with formaldehyde and amine to get
- a) Ethacrynic acid
- b) Butyrophenone
- c) Clofibrate
- d) Methacynic acid
Q.13 [4, 9-dihydro-4-(1-methyl-4-piperadineylidene)-10H- benzo [4, 5] cyclohepta [1, 2-b] Thiophen-10- one is
- a)Azatadine
- b) loratadine
- c) ketotiphen
- d) pizotiphen
Q.14 2-methyl-N-amino indoline and 3-sulphamoyl-4-chlorobenzoyl chloride are Condensed to synthesize one of the following drugs
- a) Indapamide
- b) chlorthalidone
- c) Xipamide
- d) Indomethacin
Q.15 what happens when sodium salt of toluene p-sulphonamide is condensed with n-Butyl isocynate?
- a) Sulphanilamide
- b) Sulphamethoxazole
- c) Tolbutamide
- d) Zonisamide
Q.16 Active metabolites of Primidone is
- a) 2-ethyl,2-cyclohexyl Barbiturate
- b) 2-(6-methoxy-2-naphthyl ) acetic acid
- c) 2-ethyl 2- phenyl Barbiturate
- d) 2-(6-methoxy-2-naphthyl) propionic acid
Q.17 When O-toludine is treated with 2-Bromo Propionyl bromide, further resulting product is treated with propylamine. What will be formed?
- a) Pyrrocaine
- b) Prilocaine
- c) Meprylcaine
- d) Mepivacaine
Q.18 2-iminothiazolidine is treated with phenyloxirane to get a drug in round worm is
- a) Piperazine
- b) tetramisole
- c) thiabendazole
- d) levamisole
Q.19 Phenoxybenzamine can be prepared
- a) phenol and propylene oxide
- b) 3-phenyl propanol
- c) phthlic anhydride
- d) none
Q.20 The raw materials used for the synthesis of sulfalen are
a) 4-acetamido benzene sulfonyl chloride and 2-amino-4-methyl pyrimidine
b) 4-amino benzene sulfonyl chloride and 5-amino-2-ethyl-1,3,4-thiadiazol
c) 4-amino benzene sulfonyl chloride and 5-amino-3,4-dimethyl isoxazole
d) 4-acetamido benzene sulfonyl chloride and 3-amino-2- methoxy pyrazine
Q.21 When 2-(O-aminostyryl) aniline is thermally decomposed, what will be formed?
- a) Dibenzodiazepine
- b) Dibenzoazepine
- c) benzodiazepine
- d) Dibenzoxapine
Q.22 (±)1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H imidazol-1-yl)methyl-4H Carbazol-4-one is chemical name of which one selective 5-HT3 receptor antagonist?
- a) Palonosetron
- b) Ondansetron
- c) Sumatriptan
- d) Granisetron
Q.23 Which one of the following H2-antagonist has thiazole heterocyclic ring system?
- a) Cimetidine
- b) Famotidine
- c) Ranitidine
- d) Omeprazole
Q.24 Which one is the IUPAC name of pantoprazole
a) 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
b) 2-[{[3-methyl-4-(2,2,2-trifluoromethoxy)-2-pyridyl} methyl} sulfinyl]-1H-benzimidazole
c) 5-dfluoromethoxy2-[[(3,4-dimethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole
d) 2-[{[4-(3-methoxypropoxy)-3-methyl-2- pyridinyl]methyl}sulfinyl]-1H-benzimidazole
Q.25 Under basic conditions an Aldol like condensation of 4-methyxyphenylacetonitrile and cyclohexanone yield an intermediate. Further reduction of nitrile to primary amine followed by Nmethylation to get the final product
- a) Trazadone
- b) Fluvoxamine
- c) Paroxetine
- d) Venlafaxine
Q.26 What is the name of this structure?
- a) Sparfloxacin
- b) Ciprofloxacin
- c) Gatifloxacin
- d) Moxifloxacin
Q.27 Which of the following amino glycosides is not 2-deoxy Streptamine derivative?
- a) Gentamycin
- b) Kanamycin
- c) Streptomycin
- d) Tobramycin
Q.28 The azalide is semi-synthetic 15-membered congeners in which a nitrogen atom has been introduced to expand a 14-membered precursor and this lead to an extended spectrum of action. Identify the macrolide antibiotics.
- a) Erythromycin
- b) Clarithromycin
- c) Roxithromycin
- d) Azithromycin
Q.29 Which one is starting material for synthesis of Benzodiazepines?
Q.30 Identify the correct combination of Cycloguanil with……as antimalarial drugs.
- a) Pyremethamine
- b) Trimethoprim
- c) Atovaquinone
- d) Artesunate
Q.31 Structure of niacin contin which ring?
- a) pyridine
- b) corrin
- c) imidazole
- d) furan
Q.34 1,2- dehydro,9α-fluoro, 16α-hydroxy cortisol is
- a) Prednisolone
- b) Dexamethasone
- c) Betamethasone
- d) Triamcinolone
Q.35 Pyradazino-diazepine derivative, angiotensin converting enzyme inhibitor is
- a) Captopril
- b) Ramipril
- c) Cilazapril
- d) Quinopril
Q.36 4, 7-Dichloroquinoline and 4-amino-2-(diethylaminomethyl) phenol gives
- a) Amodiaquine
- b) Mefloquine
- c) Halofantrine
- d) Chloroquine
Q.37 Benzoxazolone heterocyclic ring system is present in one of the following is
- a) Baclofen
- b) Chlorzoxazone
- c) Metazolone
- d) Lorabamate
Q.38 One of the follwing is benzyl piperidine derivative antiemetic drug
- a) Metoclopramide
- b) Cisapride
- c) Clebopride
- d) none of these
Q.39 Irinotecan acts on this phase of the cell cycle
- a) G1
- b) G2
- c) M
- d) S
Q.40 Predict the product obtained by treating 2,4-dichloro, 5-sulphamoyl benzoic acid with furfuryl amine
- a) Amiloride
- b) Hydrochlorothiazide
- c) Triamterene
- d) Furosemide
Q.41 Which one of the followings is not phase 2 conjugation reaction
- a) N-methylation
- b) Sulfate conjugation
- c) Hydroxylation
- d) Glucuronidation
Q.42 Intravenous immunoglobulin is used in one of the following pathological conditions
- a) Urticaria
- b) Autoimmune thrombocytopenia
- c) Rheumatoid arthritis
- d) none
Q.43 Which one of the followings is Cysteinyl-leukotrene receptor antagonist
- a) Budesonide
- b) Zafirlukast
- c) Salmeterol
- d) Bambuterol
Q.44 Which one of the following is not a intermediate in cholesterol biosynthesis
- a) Geranyl pyrophosphate
- b) Faenesyl pyrophosphate
- c) Squalene
- d) Naftifine
Q.45 Which of the following drug is analogoue of Inosine monophosphate?
- a) Stavudine
- b) Didanosine
- c) Lamuvidine
- d) Zidovudine
Q.46 Which one of the followings is structure of clopidogrel
Q.47 Which is 4-substituted indolone derivative D2-agonist &used in Parkinson’s disease
- a) Bromocriptine
- b) Pramipexole
- c) Pergolide
- d) Ropinirol
Q.48 Which one of the following is phenyl alanine derivative hypoglycemic drug
- a) Repaglinide
- b) Nateglinide
- c) Glimepride
- d) Glipizide
Q.49 Granular copolymer of tetraethylene and epicholohydrin and hypolipidaemic is
- a) Colestipole hydrochloride
- b) Cholestyramine
- c) Fibrate
- d) Gemfibrozil
Q.50 N-methyl-substitution of 4-phenylpiperidine-4-ethyl-carboxylate derivative is
- a) Fentanyl
- b) Diphenoxylate
- c) Pethidine
- d) Anileridine
Answers
