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Medicinal chemistry (Part:- 1) MCQs with Answers

MEDICINAL CHEMISTRY

Q.1 resorcinol is treated with p-toludine, the resulting product when reacted with 2-chloro Methyl Δ2-imidazoline hydrochloride gave the product A. What is structure of A?

  1. a) Phentolamine
  2. b) Pheoxybenzamine
  3. c) Tolazaline
  4. d) Naphazoline

Q.2 Dienoesterol is synthesized from

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Q.3 one of these statins is synthetic that inhibits HMG-CoA Reductase and has heptanoic Acid side chain.

  1. a) Pravastatin
  2. b) Mevastatin
  3. c) Atorvastatin
  4. d) Lovastatin

Q.4 A drug which is used in Cysticercosis and synthesize from m-chloro salicylic acid and 4- chloroaniline in the presence of pyridine and phenyl chloride at temp 1250C.

  1. a) Nikethimide
  2. b) Niclosamide
  3. c) pyrantel
  4. d) niridazole

Q.5 Cis-1-Acetyl-4-[4-[[2-(2, 4-dichlorophenyl)-2-(1H Imidazole-1-yl methyl)-1, dioxalan4yl] methoxy] phenyl] piperazine is

  1. a) Ketoconzole
  2. b) Itraconazole
  3. c) Fluconazole
  4. d) Terconazole

Q.6. what is the IUPAC name of Flurandrenolone
a) 6α-Fluoro 11β, 17, 21-trihydroxy-pregna-1, 4-diene 3, 20 Dione
b) 6α-methyl 9-fluoro 11β, 17, 21-trihydroxy-pregna-1, 4-diene 3, 20 Dione
c) 6α, 9-difluoro 11β, 16β, 17, 21-tetrahydroxy-pregna-1, 4-diene 3, 20 Dione
d) 6α fluoro 11β,16α,17,21-tetrahydroxy-pregna-1,4-diene 3,20 dione

Q.7 what type of drug interaction between Antacid & H2-Antagonists with ketaconazole?

  1. a) Inhibit absorption
  2. b) increase absorption
  3. c) increase metabolism
  4. d) inhibit metabolism

Q.8 Probencid is used in gout increase bioavailability of penicillin by

  1. a) Inhibiting metabolism
  2. b) inhibiting renal excretion
  3. c) increasing metabolism
  4. d) none

Q.9 Pheniramine malate is an antihistaminic agent belongs to the class

  1. a) Ethylene diamine derivative
  2. b) Cyclic basic class analogue
  3. c) Amino alkyl ether analogue
  4. d) none of these

Q.10 Promazine contains side chain

  1. a) –CH2-CH2-NH-CH3
  2. b) –CH2-CH2-CH2-N (CH3)2
  3. c) –CH2-CH2 (CH3) NH-CH3
  4. d) –CH2-CH (CH3)-CH2-N (CH3)2

Q.11 All of the following drugs are sugar nucleoside except

  1. a) Didnosine
  2. b) Zalcitabine
  3. c) lamivudine
  4. d) Stavudine

Q.12 when 2,3-dichlorophenoxy acid is treated with butyryl chloride in the presence of AlCl3 and the intermediate is further reacted with formaldehyde and amine to get

  1. a) Ethacrynic acid
  2. b) Butyrophenone
  3. c) Clofibrate
  4. d) Methacynic acid

Q.13 [4, 9-dihydro-4-(1-methyl-4-piperadineylidene)-10H- benzo [4, 5] cyclohepta [1, 2-b] Thiophen-10- one is

  1. a)Azatadine
  2. b) loratadine
  3. c) ketotiphen
  4. d) pizotiphen

Q.14 2-methyl-N-amino indoline and 3-sulphamoyl-4-chlorobenzoyl chloride are Condensed to synthesize one of the following drugs

  1. a) Indapamide
  2. b) chlorthalidone
  3. c) Xipamide
  4. d) Indomethacin

Q.15 what happens when sodium salt of toluene p-sulphonamide is condensed with n-Butyl isocynate?

  1. a) Sulphanilamide
  2. b) Sulphamethoxazole
  3. c) Tolbutamide
  4. d) Zonisamide

Q.16 Active metabolites of Primidone is

  1. a) 2-ethyl,2-cyclohexyl Barbiturate
  2. b) 2-(6-methoxy-2-naphthyl ) acetic acid
  3. c) 2-ethyl 2- phenyl Barbiturate
  4. d) 2-(6-methoxy-2-naphthyl) propionic acid

Q.17 When O-toludine is treated with 2-Bromo Propionyl bromide, further resulting product is treated with propylamine. What will be formed?

  1. a) Pyrrocaine
  2. b) Prilocaine
  3. c) Meprylcaine
  4. d) Mepivacaine

Q.18 2-iminothiazolidine is treated with phenyloxirane to get a drug in round worm is

  1. a) Piperazine
  2. b) tetramisole
  3. c) thiabendazole
  4. d) levamisole

Q.19 Phenoxybenzamine can be prepared

  1. a) phenol and propylene oxide
  2. b) 3-phenyl propanol
  3. c) phthlic anhydride
  4. d) none

Q.20 The raw materials used for the synthesis of sulfalen are
a) 4-acetamido benzene sulfonyl chloride and 2-amino-4-methyl pyrimidine
b) 4-amino benzene sulfonyl chloride and 5-amino-2-ethyl-1,3,4-thiadiazol
c) 4-amino benzene sulfonyl chloride and 5-amino-3,4-dimethyl isoxazole
d) 4-acetamido benzene sulfonyl chloride and 3-amino-2- methoxy pyrazine

Q.21 When 2-(O-aminostyryl) aniline is thermally decomposed, what will be formed?

  1. a) Dibenzodiazepine
  2. b) Dibenzoazepine
  3. c) benzodiazepine
  4. d) Dibenzoxapine

Q.22 (±)1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H imidazol-1-yl)methyl-4H Carbazol-4-one is chemical name of which one selective 5-HT3 receptor antagonist?

  1. a) Palonosetron
  2. b) Ondansetron
  3. c) Sumatriptan
  4. d) Granisetron

Q.23 Which one of the following H2-antagonist has thiazole heterocyclic ring system?

  1. a) Cimetidine
  2. b) Famotidine
  3. c) Ranitidine
  4. d) Omeprazole

Q.24 Which one is the IUPAC name of pantoprazole
a) 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
b) 2-[{[3-methyl-4-(2,2,2-trifluoromethoxy)-2-pyridyl} methyl} sulfinyl]-1H-benzimidazole
c) 5-dfluoromethoxy2-[[(3,4-dimethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole
d) 2-[{[4-(3-methoxypropoxy)-3-methyl-2- pyridinyl]methyl}sulfinyl]-1H-benzimidazole

Q.25 Under basic conditions an Aldol like condensation of 4-methyxyphenylacetonitrile and cyclohexanone yield an intermediate. Further reduction of nitrile to primary amine followed by Nmethylation to get the final product

  1. a) Trazadone
  2. b) Fluvoxamine
  3. c) Paroxetine
  4. d) Venlafaxine

Q.26 What is the name of this structure?

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  1. a) Sparfloxacin
  2. b) Ciprofloxacin
  3. c) Gatifloxacin
  4. d) Moxifloxacin

Q.27 Which of the following amino glycosides is not 2-deoxy Streptamine derivative?

  1. a) Gentamycin
  2. b) Kanamycin
  3. c) Streptomycin
  4. d) Tobramycin

Q.28 The azalide is semi-synthetic 15-membered congeners in which a nitrogen atom has been introduced to expand a 14-membered precursor and this lead to an extended spectrum of action. Identify the macrolide antibiotics.

  1. a) Erythromycin
  2. b) Clarithromycin
  3. c) Roxithromycin
  4. d) Azithromycin

Q.29 Which one is starting material for synthesis of Benzodiazepines?

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Q.30 Identify the correct combination of Cycloguanil with……as antimalarial drugs.

  1. a) Pyremethamine
  2. b) Trimethoprim
  3. c) Atovaquinone
  4. d) Artesunate

Q.31 Structure of niacin contin which ring?

  1. a) pyridine
  2. b) corrin
  3. c) imidazole
  4. d) furan

Q.34 1,2- dehydro,9α-fluoro, 16α-hydroxy cortisol is

  1. a) Prednisolone
  2. b) Dexamethasone
  3. c) Betamethasone
  4. d) Triamcinolone

Q.35 Pyradazino-diazepine derivative, angiotensin converting enzyme inhibitor is

  1. a) Captopril
  2. b) Ramipril
  3. c) Cilazapril
  4. d) Quinopril

Q.36 4, 7-Dichloroquinoline and 4-amino-2-(diethylaminomethyl) phenol gives

  1. a) Amodiaquine
  2. b) Mefloquine
  3. c) Halofantrine
  4. d) Chloroquine

Q.37 Benzoxazolone heterocyclic ring system is present in one of the following is

  1. a) Baclofen
  2. b) Chlorzoxazone
  3. c) Metazolone
  4. d) Lorabamate

Q.38 One of the follwing is benzyl piperidine derivative antiemetic drug

  1. a) Metoclopramide
  2. b) Cisapride
  3. c) Clebopride
  4. d) none of these

Q.39 Irinotecan acts on this phase of the cell cycle

  1. a) G1
  2. b) G2
  3. c) M
  4. d) S

Q.40 Predict the product obtained by treating 2,4-dichloro, 5-sulphamoyl benzoic acid with furfuryl amine

  1. a) Amiloride
  2. b) Hydrochlorothiazide
  3. c) Triamterene
  4. d) Furosemide

Q.41 Which one of the followings is not phase 2 conjugation reaction

  1. a) N-methylation
  2. b) Sulfate conjugation
  3. c) Hydroxylation
  4. d) Glucuronidation

Q.42 Intravenous immunoglobulin is used in one of the following pathological conditions

  1. a) Urticaria
  2. b) Autoimmune thrombocytopenia
  3. c) Rheumatoid arthritis
  4. d) none

Q.43 Which one of the followings is Cysteinyl-leukotrene receptor antagonist

  1. a) Budesonide
  2. b) Zafirlukast
  3. c) Salmeterol
  4. d) Bambuterol

Q.44 Which one of the following is not a intermediate in cholesterol biosynthesis

  1. a) Geranyl pyrophosphate
  2. b) Faenesyl pyrophosphate
  3. c) Squalene
  4. d) Naftifine

Q.45 Which of the following drug is analogoue of Inosine monophosphate?

  1. a) Stavudine
  2. b) Didanosine
  3. c) Lamuvidine
  4. d) Zidovudine

Q.46 Which one of the followings is structure of clopidogrel

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Q.47 Which is 4-substituted indolone derivative D2-agonist &used in Parkinson’s disease

  1. a) Bromocriptine
  2. b) Pramipexole
  3. c) Pergolide
  4. d) Ropinirol

Q.48 Which one of the following is phenyl alanine derivative hypoglycemic drug

  1. a) Repaglinide
  2. b) Nateglinide
  3. c) Glimepride
  4. d) Glipizide

Q.49 Granular copolymer of tetraethylene and epicholohydrin and hypolipidaemic is

  1. a) Colestipole hydrochloride
  2. b) Cholestyramine
  3. c) Fibrate
  4. d) Gemfibrozil

Q.50 N-methyl-substitution of 4-phenylpiperidine-4-ethyl-carboxylate derivative is

  1. a) Fentanyl
  2. b) Diphenoxylate
  3. c) Pethidine
  4. d) Anileridine

Answers

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