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pharmacy Topic wise MCQs

Pharmaceutical Analysis (Part:- 4) MCQs with answers


Q.51 the B.P. assay of Nifedipine is by titration of a
a) Solution in anhydrous acetic acid with 0.1M perchloric acid
b) Solution in previously neutralized acetone with 0.1N sodium hydroxide; end point by potentiometry
c) Solution in previously neutralized acetone against standard potassium dichromate solution
d) A solution in 2-methyl- 2- propranol and perchloric acid with 0.1M cerium sulphate using ferroin as indicator

Q.52 which one of equation is related to column chromatography
a) id = 708 nCD½ m2/3 t1/6
b) VR = tR Fc
c) E = E0 – RT log [H+]/n F
d) A = εbc

Q.53 Polarography can be used for the
a) To study fluorescent material
b) Study of resistance of a solution
c) Study of current potential relationship
d) Study of optical activity of organic molecules

Q.54 Derivatization is done in gas chromatography for
a) Improve the thermal stability of compounds
b) Change the separation properties of compounds by the purposeful adjustment of their volatility
c) Introduce a detector oriented tag into a molecule
d) All of these

Q.55 how many signals are produced by methyl cyclopropane?
A) two
b) Three
C) four
D) five

Q.56 Hydrogen absorbency index and nitrogen rules are related to
a) UV Spectroscopy
b) IR Spectroscopy
c) NMR Spectroscopy
d) Mass Spectroscopy

Q.57 the Flame ionization detector is the most popular detector because of its
a) High sensitivity
b) Short range of linearity
c) Low reliability
d) Universal response

Q.58 which one of these is not a hyphenated technique?
a) GC-MS
b) GC-IR
c) FT-IR
d) MS-MS

Q.59 A thermistor detector functions by changing………when heated
a) Frequency
b) Pressure
c) Voltage
d) Resistance

Q.60 In NMR if the atom contains three nearby protons then these will produce
a) Doublet
c) Triplet
c) Quartet
d) Sestet

Q.61 0.25 g of a compound C10H15NO.HCl was titrated with 0.1 M consumed 12.5 ml of the titrant, Calculate the percentage purity of given sample
a) 98.3
b) 99.25
c) 94.72
d) 100.75

Q.62 Erichrome black T is used indicator in which type of titration?
a) Neutralization
b) Precipitation
c) Redox
d) Complexometric

Q.63 PYRIDOXINE HCl IP is dissolved in glacial acetic acid and then the inorganic reagent is added. What is the name of inorganic agent?
a) Potassium Methoxide solution
b) Mercuric acetate solution
c) Tetra butyl ammonium hydroxide solution
d) ceric ammonium sulphate solution

Q.64 which one of the following solvent is not used in NMR Spectroscopy?
a) Carbon di sulfide
b) Deuterated chloroform
c) Carbon tetra chloride
d) Water

Q.65 the reference material used in NMR Spectroscopy is
a) Trimethyl silane
b) Tetramethyl silane
c) Both of these
d) None of these

Q.66……. produced in the fragmentation cannot be detected in the mass spectrometer.
a) Neutral molecules
b) Molecular ions
c) Metastable ions
d) Parent ions

Q.67 the pyroelectric detectors use ferroelectric materials operating below Curie point temperature is composed of
a) Oxides of Mn, Co and Ni
b) Bi-Sb
c) Xenon
d) Triglycin sulphate

Q.68 the most widely used material for preparing infrared cells for liquid samples and discs for solid samples is
a) Potassium bromide
b) Potassium chloride
c) Sodium bromide
d) Calcium bromide

Q.69 the main sources of infrared radiation used in spectrophotometers are except
a) The Nernst glower
b) Nicrome wire wound on ceramic support
c) Mercury vapour lamp
d) The Globar, a bonded silicon carbide rode

Q.70 The wave number 1720-1740 cm-1 for carbonyl group is characteristic band for
a) Aldehyde
b) Ketone
c) Acid
d) Esters

Q.71 what is approximate wavelength of green color?
a) 450-500 nm
b) 500-570 nm
c) 570-590 nm
d) 590-620 nm

Q.72 Sorensen apparatus is used for determination of
a) Crystal growth
b) pH scale
c) HLB value
d) Interparticular force

Q.73 Chlormbucil is assayed as per IP by titrating a dilute acetone solution of the drug with
a) 0.1 M sodium hydroxide
b) 0.1 M hydrochloric acid
c) 0.2 M perchloric acid
d) 0.1 M silver nitrate

Q.74 Official assay for the Glibenclamide is by titration using a standard solution of
a) Sodium nitrite
b) Iodine
c) Potassium permanganate
d) Sodium hydroxide

Q.75 what will be the range of finger print region in cm-1 (wave number)
A) 5000-1600
B) 8000-1600
C) 1600-600
D) 3000-1600

Q.76 In Fluorescence, the energy is emitted by
a) Singlet
b) Triplet
C) Radical
d) None

Q.77 The Potential at the point on the polarographic wave where the current is equal to one half of the diffusion current is termed as
a) Half wave current
b) Full wave Current
c) Half wave Potential
d) Full wave Potential

Q.78 which one is not a reference electrode
a) Silver-silver chloride
b) Mercury- calomel
c) Dropping mercury
d) Hydrogen

Q.79 what is the unit of molar conductivity?
a) mho
b) Ω-1cm-1
c) Ω-1cm2mol-1
d) Ω-cm

Q.80 in Conductometric titrations, one of the following is evaluated by calibration with 0.1M potassium chloride
a) Distance between two electrodes
b) Cell constant
c) Area of cross section of each electrode
d) Platinum wire of electrode

Q.81 in Mass spectroscopy, positive charged in can be produced by
a) Heating the sample
b) Bombarding the sample with high energy electrons
c) Bombarding the sample with high energy protons
d) Bombarding the sample with high energy photons

Q.82 if a proton is coupled with N other equivalent protons the number of peaks in multiplet is N+1 and the relative intensities of these multiplets are determined by
a) Cram’s rule
b) Pascal’s triangle
c) Chemical shift
d) Bedth’s rule

Q.83 Parts per million (PPM) is unit for measurement of
a) Coupling constant
b) Wave number
c) Base peak
d) Chemical shift

Q.84 In Mass Spectra, the peak that has highest relative abundance (100%) is known as
a) Base
b) Metastable ion
b) Fragment ion
d) Rearrangement ion

Q.85 what is the mechanism of liquid chromatography for seperation of samples
a) Adsorption
b) Partition
c) Absorbtion
d) None of these

Q.86 Octadecyl silane (C-18) column is used in………….chromatography.
a) Ion Pair
b) Size Exclusion
c) Bonded Phase
d) Ion exchange

Q.87 Pulse damper is used with which type of reciprocating piston pumps
a) Single head
b) Dual head
c) Triple head
d) None of these

Q.88 A sample is injected onto a given column and mobile phase is unchanged throughout the time required for sample components to elute from the column is known as
a) Gradient elution
b) Solvent programming
c) Mobile phase elution
d) Isocratic elution

Q.89 The simplest form of preparative thin layer chromatoghraphy is to use
a) Glass plate
b) Aluminium plate
c) Coated plate
d) Uncoated plate

Q.90 what is the use of T.L.C.
a) To establish the purity and authenticity of starting material
b) To monitor the reaction
c) To check the isolation and purification procedures
d) All of these

Q.91 The energy absorbed in…………produces changes in rotational, vibrational, and electronic energy of the molecule
a) U.V. region
b) I.R. region
c) NMR region
d) Microwave region

Q.92 what is the wave length of microwave that are used to produce electron spin resonance
a) 10 nm-100 nm
b) 100 nm-1000 nm
c) 1 mm-30 cm
d) 100 cm-500 cm

Q.93 Ionic mobility is denoted by
a) cm/sec
b) Degree Celcius/sec
c) mg/sec
d) None of these

Q.94 which is used for dispersing the incident radiation in UV spectroscopy?
a) Nicol Prism
b) Diffraction grating
c) Both of these
d) None of these

Q.95 The Work of Heyrovsky is related to the discovery of ………technique for which he received the Noble prize in 1959.
a) Potentiometry
b) Polarimetry
c) Polarography
d) Amperometry

Q.96 When the potential applied across two electrode is maintained at some constant value, the current is measures and plotted against the volume of the titrant is known as
a) Potentiometry
b) Conductometry
c) Polarography
d) Amperometry

Q.97 the substituent that delocalizes the pi electrons and enhances the fluorescence is
A) -Cl
b) -NO2
c) -NH2
d) –COOH

Q.98 which of these is not an emission spectroscopy
a) Fluorimetry
b) Fluorescence
c) Phosphorescence
d) Infrared

Q.99 which one is not used as oxidant in Flame emission spectroscopy?
a) Air
b) Nitrous oxide
c) Hydrogen
d) Oxygen

Q.100 The ratio of cell constant and resistance in Conductometric titration is known as
a) EMF
b) Specific conductance
c) Standard potential
d) None of these

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