Pharmacokinetics: The Absorption, Distribution, and Fate of Drugs
1. Protein molecules serve which purpose in a plasma membrane?
a. Provide insulation for the cell.
b. Rid the cell of cholesterol and lipids.
c. Prevent drugs from crossing the plasma membrane.
d. Provide a link between the intracellular and extracellular environments.
2. A drug moves down its electrochemical gradient while crossing the plasma membrane in
c. active transport.
d. passive diffusion.
3. The majority of oral drug absorption takes place in the
b. large intestine.
c. small intestine.
d. esophageal mucosa.
4. Which is NOT a disadvantage of administering a drug intravenously?
a. Possible hematoma formation.
b. Accidental intra-arterial injection.
c. Production of immediate drug effects.
d. Toxic drug reactions are difficult to reverse.
5. The transport of electrically charged fluoride into hypersensitive dentin is called
c. parenteral injection.
d. percutaneous absorption.
6. Which membrane is the first tissue barrier a majority of drugs must cross after intravenous administration?
7. Which is NOT a factor of the blood-brain barrier?
a. Glomerular filtration.
b. Drug export carrier system.
c. Astrocytic capillary sheath.
d. Modified capillary endothelium.
8. Which organ contains the most important enzyme systems for metabolizing drugs?
9. Which chemical reaction is most often involved in hepatic metabolism?
d. Glucuronide conjugation.
10. Which is the major organ of drug excretion?