1. The bond angles in sp carbon are usually
a. 120
b. 180
c. 90
d. 45
2. How many electrons are present in the valence shell of phosphorus?
a. 2
b. 3
c. 4
d. 5
3. Which of the following undergo tautomerization?
a. Amides
b. Alcohols
c. Carboxylic a cids
d. Alkanes
4. WosterÕs Steering Wheel trick is used to assign for a molecule
a. D/L-Form
b. R/S-Form
c. d/l-Form
d. E/Z-Form
5. The concept that the concentration of a drug in plasma is directly related to its activity was given by
a. Henderson Hasselbach equation
b. Overton Meyer h ypothesis
c. Ferguson hypothesis
d. Hammetts equation
6. Is-group does not include
a. Halogens
b. Oximes
c. Alkanes
d. Alkenes
7. Pyrrole nitrogen has a pK a of
a. 0.27
b. 0.27
c. 1.25
d. 1.25
8. One of the following is bioisoster for carboxylic acid
a. Tetrazole
b. Carbonyl
c. Amides
d. Esters
9. The concept of nicotine that acted at sympathetic ganglia even after the degeneration of the severed preganglionic nerve endings was proposed by
a. Langley
b. Clark
c. Ehlrich
d. Paton
10. Which theory assumes that the substrate plays
a role in determining the Þ nal shape of the enzyme?
a. Rate theory
b. Occupancy theory
c. Induced theory
d. Activation aggravation theory
11. One of the following receptors is sensitive to inverse agonist:
a. GABA A receptor
b. Seratonin 5- HT 3 receptor
c. Dopamine D 1 receptor
d. Adrenergic α receptor
12. Which of the following can be a good therapeutic agent when the safe dose range can be greatly extended?
a. Full a gonist
b. Partial a gonist
c. Inverse a gonist
d. Full a ntagonist
13. Which of the following is the strongest bonding between drug and receptor?
a. Ionic bondi ng
b. Hydrogen b onding
c. Covalent bondi ng
d. Van de r Waals bonding
14. Which interaction between a drug and a receptor would favour a permanent damage of killing of the cells?
a. Inter-hydrogen bondi ng
b. Intra-hydrogen bondi ng
c. Covalent bondi ng
d. Hydrophobic bonding
15. The charge of dipole compared to an ion is
a. Lesser
b. Same
c. Greater
d. Sometimes less and sometimes greater
16. In the biological pH, the amino acid with a permanent dipole is
a. Alanine
b. Phenylalanine
c. Tyrosine
d. Lysine
Answer keys
1. b
2. d
3. a
4. b
5. c
6. c
7. b
8. a
9. a
10. c
11. d
12. b
13. c
14. c
15. a
16. c
