- synthetic pathway- Mechlorethamine, 6-Mercaptopurine
- 6-Mercaptopurine (6-MP)
- IUPAC nomenclature
Methods of Synthesis
- Nitrogen Mustards Mechlorethamine (Mustine HCl) Cyclophosphamide, Ifosfamide, Chlorambucil, Melphalan 2.Ethylenimine Thio-TEPA 3.Alkyl sulfonate Busulfan 4.Nitrosoureas Carmustine (BCNU), Lomustine (CCNU) 5.Triazine Dacarbazine (OTIC)
- 6. Also knows as Mustine HCl. 1st nitrogen mustard ; highly reactive ; local vesicant . Administration only by IV route . Nausea , vomiting , haemodynamic changes (acute effects) are common side effects. Extravasation during IV injection may cause sloughing. Dose – 0.1 mg/Kg IV daily * 4 days (courses may be repeated at suitable interval).