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Nursing pharmacy Topic wise MCQs

The Respiratory System MCQs

1. Source of pulmonary surfactant is:
A. Alveolar macrophages
B. Type I pneumocytes
C. Type II pneumocytes
D. Capillary basement membrane

2. The basic defect in neonatal hyaline membrane disease is:
A. Shock due to sepsis
B. Deficient production of surfactant
C. Inhalation of toxins
D. Aspiration pneumonitis

3. Adult respiratory distress syndrome occurs from the following causes except:

  1. A. Pancreatitis
  2. B. Oxygen toxicity
  3. C. Deficiency of surfactant
  4. D. Diffuse pulmonary infections

4. Primary atelectasis is defined as:
A. Incomplete expansion of a previously unexpanded lung
B. Reduction in size of a previously expanded lung due to compres-
sion
C. Reduction in size of a lung due to obstruction
D. Reduction in lung size due to contraction

5. Pulmonary hypertension is defined as systolic blood pressure in the pulmonary arterial circulation above the following cut off figure:

  1. A. 120 mmHg
  2. B. 90 mmHg
  3. C. 60 mmHg
  4. D. 30 mmHg

6. Bronchopneumonia is grossly characterised by:
A. Diffuse consolidation of a lobe or lobes of one or both lungs
B. Diffuse consolidation of a lobe of one lung
C. Diffuse consolidation of a lobe of both lungs
D. Patchy consolidation of a lobe or lobes of one or both lungs

7. The most common causative organism for lobar pneumonia is:

  1. A. Staphylococci
  2. B. Streptococci
  3. C. Pneumococci
  4. D. Haemophilus

8. Viral pneumonias are characterised by the following features except:
A. Presence of interstitial inflammation
B. Presence of alveolar exudate
C. Necrotising bronchiolitis
D. Multinucleate giant cells in the bronchiolar wall

9. The organism in Pneumocystis pneumonia is:

  1. A. Mycoplasma
  2. B. Fungus
  3. C. Protozoa
  4. D. Chlamydia

10. Lung abscess secondary to aspiration pneumonia develops more often in:

  1. A. Lower lobe of right lung
  2. B. Lower lobe of left lung
  3. C. Upper lobe of either lung
  4. D. Middle lobe of right lung

11. Reid index used as a criteria of quantitation in chronic bronchitis is the ratio of thickness of:
A. Bronchial mucosa to that of bronchial wall
B. Submucosal glands to that of bronchial wall
C. Bronchial cartilage to that of bronchial wall
D. Inflammatory infiltrate to that of bronchial wall

12. The most fibrogenic dust in pneumoconiosis is:

  1. A. Coal
  2. B. Asbestos
  3. C. Silica
  4. D. Beryllium

13. Classic a-1 antitrypsin deficiency in emphysema has the following phenotype of protease inhibitor:

  1. A. PiMM
  2. B. PiZZ
  3. C. PiMZ
  4. D. PiMO

14. The extent of damage to pulmonary parenchyma is severest in the following type of emphysema:

  1. A. Centriacinar
  2. B. Panacinar
  3. C. Distal acinar
  4. D. Irregular

15. Emphysema associated most often with a1 antitrypsin deficiency is:

  1. A. Panacinar
  2. B. Centriacinar
  3. C. Distal acinar
  4. D. Irregular

16. Serum IgE levels are elevated in:
A. Intrinsic bronchial asthma
B. Extrinsic bronchial asthma
C. Predominant chronic bronchitis
D. Predominant emphysema

17. Bronchiectasis commonly develops in the following microanatomic zone of bronchial tree:
A. Acini beyond respiratory bronchioles
B. Acini beyond terminal bronchioles
C. Terminal bronchioles less than 2 mm diameter
D. Bronchioles more than 2 mm diameter

18. Restrictive lung disease is characterised by the following features except:

  1. A. Dyspnoea
  2. B. Tachypnoea
  3. C. Cyanosis
  4. D. Wheezing

19. Inhaled dust particles of the following size are generally eliminated by expectoration:

  1. A. Smaller than 1 µm
  2. B. 1-3 µm
  3. C. 3-5 µm
  4. D. Larger than 5 µm

20. Bronchogenic carcinoma has increased incidence in the following pneumoconiosis:
A. Coal workers’ pneumoconiosis
B. Silicosis
C. Asbestosis
D. Berylliosis

21. Silicosis occurs in following occupational exposure except:

  1. A. Ceramic workers
  2. B. Foundry workers
  3. C. Textile workers
  4. D. Construction workers

22. Out of various forms of asbestos, the following type is implicated in etiology of malignant pleural tumour:

  1. A. Chrysotite
  2. B. Crocidolite
  3. C. Amosite
  4. D. Anthophyllite

23. Caplan’s syndrome may develop in the following types of pneumoconiosis except:

  1. A. Coal-workers’ pneumoconiosis
  2. B. Asbestosis
  3. C. Berylliosis
  4. D. Silicosis

24. Non-caseating sarcoid-like epithelioid cell granulomas are seen in:

  1. A. Silicosis
  2. B. Asbestosis
  3. C. Coal-workers’ pneumoconiosis
  4. D. Chronic berylliosis

25. The following histologic types of bronchogenic carcinoma have strong association with cigarette smoking except:

  1. A. Squamous cell carcinoma
  2. B. Small cell carcinoma
  3. C. Large cell carcinoma
  4. D. Adenocarcinoma

26. The following type of bronchogenic carcinoma has worst prognosis:

  1. A. Squamous cell carcinoma
  2. B. Small cell carcinoma
  3. C. Large cell carcinoma
  4. D. Adenocarcinoma

27. Bronchial carcinoid arises from:

  1. A. Columnar ciliated epithelium
  2. B. Goblet cells
  3. C. Kulchitsky cells
  4. D. Alveolar lining cells

28. The following tumour does not have association with occupational exposure to asbestosis:

  1. A. Benign mesothelioma
  2. B. Malignant mesothelioma
  3. C. Bronchogenic carcinoma
  4. D. Laryngeal carcinoma

29. Macrophage-derived fibrogenic cytokine is:

  1. A. IL-1
  2. B. IL-8
  3. C. TNF
  4. D. TGF a

30. The most important mutation in small cell carcinoma is in the following gene:

  1. A. RB gene
  2. B. MYC gene
  3. C. CDK gene
  4. D. RAS gene

31. Hamman-Rich syndrome is:
A. Bronchopulmonary dysplasia
B. Desquamative interstitial pneumonia
C. Diffuse fibrosing alveolitis
D. ARDS

32. Most common etiologic factor implicated in chronic bronchitis is:

  1. A. Atmospheric pollution
  2. B. Cotton mills
  3. C. Mycoplasma infection
  4. D. Cigarette smoking

33. Which type of asthma occurs in late adult life:

  1. A. Atopic asthma
  2. B. Intrinsic asthma
  3. C. Mixed asthma
  4. D. Allergic asthma

34. Asbestos exposure results in all of the following changes except:

  1. A. Interstitial pneumonia
  2. B. Pleural effusion
  3. C. Malignant mesothelioma
  4. D. Pleural fibrosis

35. All are types of allergic pneumonitis except:

  1. A. Bagassosis
  2. B. Byssinosis
  3. C. Berryliosis
  4. D. Farmer’s lung

36. Which of the following mutation is being used to develop targeted molecular therapy in non-small cell cancer of lung?

  1. A. EGFR mutation
  2. B. p53 mutation
  3. C. K-RAS mutation
  4. D. p16 mutation

37. Which of the following histologic types of carcinomas is most likely to be found at the periphery of the lung preceded by healed lung lesions?
A. Adenocarcinoma
B. Large cell carcinoma
C. Small cell carcinoma
D. Squamous cell carcinoma

Answers Key
1) = C, 2) = B, 3) = C, 4) = A, 5) = D, 6) = D, 7) = C, 8) = B, 9) = B, 10) = A, 11) = B, 12) = C, 13) = B, 14) = B, 15) = A, 16) = B, 17) = D, 18) = D, 19) = D, 20) = C, 21) = C, 22) = B, 23) = C, 24) = D, 25) = D, 26) = B, 27) = C, 28) = A, 29) = D, 30) = A, 31) = C, 32) = D, 33) = B, 34) = A, 35) = C, 36) = A, 37) = A