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Therapuetic Drug Monitoring Of Phenytoin

THERAPUETIC DRUG MONITORING
OF PHENYTOIN

CASE STUDY:
60 kg woman taking Phenytoin at 100mg tid for last 6 months.She visits outpatient clinical and complaint of having fits despite of taking drug regularly.Her serum drug level is 10mg/l.
HINTS:
• What dose is 100 mg is required to raie level to 15mg/l
• Check answer using orbit.
• If Phenytoin suspension,suggest the dose adjustment.
SOLUTION:
Wt = 60kg
Dose = 100 mg tid
Serum drug level = 10mg/

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= 50400/106.1

= 475 mg

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