Remix education
Daily Pharma QuizpharmacyTopic wise MCQs

Novel drug delivery system MCQs with Answers

Current advances in novel drug delivery system MCQs with Answers

1. Liposomes are spherical structures, usually between in diameter……………..
a) 80nm-100nm
b) 60nm-100nm
c) 55nm-1000nm
d) 15nm-1000nm
Ans.: d

2. Liposomes consists of a bilayer of…………………
a) Hydrophilic molecules
b) Hydrophobic molecules
c) Both a and b
d) None
Ans.: c

3. Liposomes have half-life …………….
a) Longer
b) Shorter
c) Intermediate
d) Both a and b
Ans.: b

4. Liposome phospholipids undergoes ………………
a) Oxidation
b) Hydrolysis
c) Acetylation
d) Both a and b
Ans. : b

5. Intermediate sized unilamellar vesicles are prepared by
a) Sonication
b) High pressure extrusion technique
c) Detergent dialysis
d) Both b and c
Ans.: d

6. The diameter of Small unilamellar vesicles is
a) 20-100nm
b) 20-1000nm
c) 10-100nm
d) 100nm-400nm
Ans. : a

7. Tranfersome belongs to the classification according to
a) Composition
b) Application
c) Function
d) None of the above
Ans.: c

8. Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”.
a) Lower
b) Higher
c) Single
d) None of the above
Ans.: a

9. Passive Loading Technique includes…………..
a) Lyophilization
b) Proliposomes
c) Solvent dispersion
d) Both a and b
Ans. : c

10. Loading of the entrapped agents before/during the manufacture procedure is known as…………
a) Active loading
b) Passive loading
c) Both a and b
d) None of the above
Ans.: b

11. Drawback of Lipid hydration method is
a) Low internal volume
b) High encapsulation efficiency
c) Size distribution is homogenous
d) None of the above
Ans.: a

12. Tip of sonicator is directly engrossed into liposome dispersion in……………
a) Bath sonication
b) Probe sonication
c) None of the above
Ans.: b

13. The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs.
a) Smaller
b) Equal
c) Larger
Ans.: c

14. To produce a microemulsion of small vesicles at least _______ circulations are required
a) at least 20 circulation but not greater than 200
b) 10 circulations
c) at least 200 circulation but not greater than 2000
d) at least 2 circulations but not greater than 10
Ans.: a

15. Dried reconstituted vesicles method is performed in…………..
a) Solvent dispersion
b) Mechanical dispersion
c) Both a and b
Ans.: b

16. Solvent vaporization is also known as………………….
a) Ether injection

b) Ethanol injection
c) Double emulsification
d) Reverse-phase evaporation
Ans.: a

17. Temperature used for Ether Injection method is______ or under reduced pressure.
a) 15-25 ̊C
b) 55-65 ̊C
c) 55-85 ̊C
d) None of the above
Ans. : b

18. Ketoconazole liposomes are given by…………….
a) Lungs
b) Oral
c) Transdermal
d) Intravenous
Ans. : c

19. Amphotericin B liposomes are given……………..
a) Lungs
b) Oral
c) Transdermal
d) Intravenous
Ans.: b

20. In niosomes phospholipids are ………………
a) Present
b) Absent
c) Both a or b
d) None
Ans. : a

21. Pharmacosome belongs to the classification according to
a) Composition

b) Function
c) Application
d) None of the above
Ans. : b

22. Which of the following can be incorporated into a liposome?
a) Only drugs and viruses
b) Only Peptides and viruses due to similar characteristics
c) Only viruses
d) Drugs, peptides, viruses, bacteria
Ans. : d

23. How are MLV liposomes made?
a) 2-10 bilayers of lipid
b) Series of concentric bilayers of lipid
c) The single bilayer of lipid
d) 100 bilayer of lipid
Ans. : b

24. How are OLV liposomes made?
a) 2-10 bilayers of lipid
b) Series of concentric bilayers of lipid
c) A single bilayer of lipid
d) 100 bilayer of lipid
Ans.: a

25. Which of the following is a characteristic of the parental controlled drug release system by liposomes?
a) Free flowing powders
b) Aqueous solutions
c) Lipid bilayer enclosing the drug
d) Administration of emulsions
Ans. : c

26. Which of the following drugs can not be given as transdermal administration?
a) Drugs with very short half life

b) Drugs with narrow therapeutic index
c) Easy removal and termination
d) Drug against peptic ulcer
Ans.: d

27. What are the characteristics of the monolithic devices?
a) The drug has a large therapeutic index
b) Aqueous solution
c) Control drug release by partitioning the drug from oil
d) Administration of emulsion
Ans.: a

28. Which of the following characteristics is suitable for transdermal drug?
a) Large drug dose
b) Large molecular size
c) Drugs with narrow therapeutic index
d) Drug which are metabolized in the skin
Ans.: c

29. The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.
a) Square of time
b) The square root of time
c) Twice the time
d) Half the time
Ans.: b

30. What are the characteristics of the reservoir or membrane devices?
a) The drug has a large therapeutic index
b) Drug permeation rate is high
c) Control drug release by partitioning the drug from oil
d) Administration of emulsion
Ans.: b

31. What are the characteristics of the mixed monolithic reservoir devices?
a) The drug has a large therapeutic index

b) Drug permeation rate is high
c) The drug polymer matrix is layered by rate controlling membrane
d) Administration of emulsion
Ans.: c

32. Which of the following is false in regarding reservoir devices?
a) These devices are used when the drug permeation rate is rapid
b) The release of the drug is controlled
c) Suitable for low therapeutic index
d) The drug is contained in a powder from floating on liquid
Ans.: d

33. Which of the following is true for monolithic devices?
a) These devices are used when the drug permeation rate is rapid
b) The release of the drug is controlled
c) Suitable for drugs with large therapeutic index
d) The drug is contained in a powder form floating on liquid
Ans.: c

34. The absorption of the ophthalmic drug does not depend on which of the following?
a) Physicochemical properties of permeating molecule
b) Drainage of tears
c) Output of tears
d) Size of the eyeball
Ans.: d

35. Which of the following is false for monolithic devices?
a) The drug used for these devices has large therapeutic index
b) There are three categories of matrix devices
c) 1st type has the drug dissolved in the polymer matrix
d) 2nd type has drug delivery
Ans.: b

36. Problems with opioid TDDS include.
a) Poor patient compliance

b) Allergy
c) Constipation.
d) Respiratory depression.
Ans.: b

37. Regarding the skin:
a) The epidermis is the thickest layer.
b) The stratum corneum is the greatest barrier to transdermal transport.
c) The dermis has a rich capillary blood supply.
d) Skin hydration is a cause of inter-individual variation in drug absorption.
Ans.: d

38. How much thickness of the dermis layer?
a) 2 to 7 nm
b) 3 to 5 nm
c) 3 to 6 nm
d) 5 to 8 nm
Ans.: b

39. TDDS is usually only suitable for drugs of what level of potency?
a) Typically only for drugs of high potency.
b) Low potency
c) High to low potency
d) Low to high potency
Ans.: a

40. In the use of TDDS for drug application ? size has to be considered reasonable?
a) Strip size
b) Patch size
c) Film size
d) Diskette size
Ans.: b

41. What is the largest organ of the body?
a) Liver
b) Lungs
c) Skin
d) Brain
Ans.: c

42. Which of the following is false for Merits of the TDDS.
a) Avoidance of the First pass effect
b) A stable and controlled blood level
c) Termination at any time is conceivable
d) Skin irritation and allergic response
Ans.: d

43. How many layer are seen in monolithic TDDS design?
a) 4
b) 3
c) 5
d) 2
Ans.: 3

44. How many layer are seen in membrane-controlled system?
a) 3
b) 5
c) 4
d) 6
Ans.: c

45. A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.
a) Iontophoresis
b) Sonophoresis
c) Electrophoresis
d) Ion exchange
Ans.: a

46. A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability.
a) Iontophoresis
b) Sonophoresis
c) Electrophoresis

d) Ion exchange
Ans.: b

47. Which component are not included in combination of the SEDDS formulation?
a) Oil
b) Lipid
c) Drug
d) Wax
Ans.: d

48. SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________.
a) GIT
b) RT
c) UT
d) Liver
Ans.: a

49. SEDDSs produce emulsion with droplet size between ____________.
a) 200 to 400nm
b) 100 to 300nm
c) 10 to 100nm
d) 1000nm
Ans.: b

50. Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________.
a) 50 nm
b) 70 nm
c) 100 nm
d) 200 nm
Ans.: a

More links

➡️ Novel drug delivery system MCQs with Answers :- Click here

➡️ Novel drug delivery system MCQs with Answers (Part:- 2) :- Click here

Subject:- Novel drug delivery system
Semester:- 8th sem, sem 8